Rabbit Anti-BAX Recombinant Antibody (clone R07-4G1)

Name: Rabbit Anti-BAX Recombinant Antibody (clone R07-4G1)
SKU: VS3-XY3274
Rating: 5 (1 reviews)

CAT#: VS3-XY3274

The antibody is a recombinant rabbit antibody binding with BAX (BCL2 associated X, apoptosis regulator), which plays a role in the mitochondrial apoptotic process. It recognizes and binds to human BAX. It also has cross-reactivity against mouse or rat BAX. It has been detected using Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation and Flow cytometry.

Gene Expression

Normal Tissue Figure 1 Cerebral cortex

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4206/13374_B_7_5.jpg

Normal Tissue Figure 2 Colon

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4206/13374_A_7_3.jpg

Normal Tissue Figure 3 Liver

Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4206/13374_A_9_4.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4206/13374_A_7_5.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4206/13374_A_4_6.jpg

Normal Tissue Figure 6 Lymph node

Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4206/13374_A_7_8.jpg

RNA Expression Figure 7 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000087088-BAX

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Specifications

Host Species
Rabbit

Type
Rabbit IgG

Specificity
Human, Mouse, Rat and Hamster BAX

Species Reactivity
Human, Mouse, Rat, Hamster

Clone
R07-4G1

Applications
WB, IHC-P, IP, FC

Related Disease
Colorectal Cancer; T-Cell Acute Lymphoblastic Leukemia

Product Property

Clonality
Monoclonal

Aggregation
< 5%

Format
Liquid

Buffer
PBS (pH 7.4), 150 mM NaCl and 50% glycerol

Preservative
0.02% sodium azide

Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Shipping
Ice packs

Applications

Application Notes
WB: 1/500-1/1000
IHC: 1/50-1/100
IP: 1/20
FC: 1/50-1/100

Target

Alternative Names
BCL2L4

Gene ID
581

UniProt ID
Q07812

Long Name
BCL2 associated X, apoptosis regulator

Cellular Localization
Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

Post Translation Modifications
Ubiquitinated on Lys-128 and Lys-190. 'Lys-63'-linked polyubiquitin chains on Lys-128 are removed by USP12.

Protein Refseq
NP_001278357.1; XP_047295124.1

Function
Plays a role in the mitochondrial apoptotic process. Promotes activation of CASP3, and thereby apoptosis.

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Related Diseases

Breast Cancer

Endometrial Cancer

Gastric Cancer

Prostate Cancer

Throid Cancer

AGE-RAGE Signaling Pathway in Diabetic Complications

Amyotrophic Lateral Sclerosis

Related Signaling Pathways

p53 Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS3-XY3274.pdf

MSDS

MSDS - VS3-XY3274.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Isotype Control

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