Anti-EpCAM Antibody Prodrug, Protease Activated (VS-1025-YC211)

Name: Anti-EpCAM Antibody Prodrug, Protease Activated (VS-1025-YC211)
SKU: VS-1025-YC211
Rating: 5 (1 reviews)

CAT#: VS-1025-YC211

The Anti-EpCAM Antibody Prodrug, Protease Activated (VS-1025-YC211) is an antibody prodrug comprised of a recombinant mouse antibody targeting human EpCAM, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to EpCAM protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to EpCAM effectively. EpCAM (Epithelial Cell Adhesion Molecule) is a highly prevalent cell-surface protein that is massively overexpressed in most epithelial-derived cancers (carcinomas). Its broad, high expression makes it an excellent target for both diagnostic imaging and immunotherapy.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line MCF7

Immunofluorescent staining of human cell line MCF7 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67463/1592_H11_2_selected.jpg

Normal Tissue Figure 2 Thyroid gland

Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55098/120585_B_2_5.jpg

Normal Tissue Figure 3 Colon

Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55098/120585_A_9_3.jpg

Normal Tissue Figure 4 Kidney

Collecting ducts
Staining: High
Intensity: Strong
Quantity:>75%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55098/120585_A_8_5.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enhanced (A-431, CACO-2, CAPAN-2, OE19, RPTEC TERT1)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000119888-EPCAM

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Specifications

Host Animal
Mouse

Applications
In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay

Specificity
Human EpCAM

Target
EpCAM

Species Reactivity
Human

Isotype
IgG2a, kappa

Masking Approach
Affinity mask

Mask
A synthetic peptide

Protease Cleavable Linker
MMP-cleavable linker

Protease Substrate
MMPs

Purification
Protein A purified

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Target

Introduction
Edrecolomab is a mouse-derived monoclonal antibody targeting the cell-surface glycoprotein EpCAM/17-1A.

Alternative Names
EPCAM; CD326; CO 17A; EGP 2; EGP34; EGP40; Ep CAM

Gene ID
4072

UniProt ID
P16422

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Datasheet

Datasheet - VS-1025-YC211.pdf

MSDS

MSDS - VS-1025-YC211.pdf

COA

Certificate of Analysis Lookup

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