Anti-Human EpCAM/17-1A Recombinant Antibody (Edrecolomab)
CAT#: TAB-701
Recombinant mouse monoclonal antibody expressed in Sp2/0 mouse myeloma cells binding to human EpCAM/17-1A. Edrecolomab is a mouse-derived monoclonal antibody targeting the cell-surface glycoprotein EpCAM/17-1A, which is expressed on epithelial tissues and on various carcinomas. Preliminary studies had shown promise of a possible use in patients with stage III colorectal carcinoma. However, when put to a phase III study it did not provide any benefit when compared to conventional chemotherapeutic agents. Edrecolomab was well tolerated in these studies and as such research has now concentrated on whether it can be of any use in other forms of cancer.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67463/1592_H11_2_selected.jpg
Normal Tissue
Figure 2 Thyroid gland
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55098/120585_B_2_5.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55098/120585_A_9_3.jpg
Normal Tissue
Figure 4 Kidney
Collecting ducts
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55098/120585_A_8_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (A-431, CACO-2, CAPAN-2, OE19, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000119888-EPCAM
❮
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG2a - kappa
- Species Reactivity
- Human
- Applications
- Suitable for use in ELISA, IP, FC, FuncS, IF, Neut and most other immunological methods.
- Trade name
- panorex
- CAS
- 156586-89-9
- Generic Name
- Edrecolomab
- ATC Code
- L01XC01
- Related Disease
- Colon cancers
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Target
- Alternative Names
- Edrecolomab;panorex;156586-89-9;17-1A;MAb17-1A;Panorex;EPCAM;epithelial cell adhesion molecule;antigen identified by monoclonal AUA1 , M4S1, MIC18, TACSTD1, tumor associated calcium signal transducer 1;17 1A;323/A3;CD326;CO 17A;EGP 2;EGP34;EGP40;Ep CAM;ES
- Gene ID
- 4072
- UniProt ID
- P16422
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(Creative Biolabs Cat# TAB-701, RRID: AB_3111983)
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Biosimilar Overview
Please refer to Edrecolomab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Edrecolomab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Edrecolomab"
Afuco™ Anti-EpCAM ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-701)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant mouse monoclonal antibody expressed in Sp2/0 mouse myeloma cells binding to human EpCAM/17-1A. It is a mouse-derived monoclonal antibody targeting the cell-surface glycoprotein EpCAM/17-1A, which is expressed on epithelial tissues and on various carcinomas.
DrugMonitor™ Anti-Edrecolomab Antibody (VS-1224-YC392)Edrecolomab is a mouse-derived monoclonal antibody targeting the cell-surface glycoprotein EpCAM (17-1A). The DrugMonitor™ Anti-Edrecolomab Antibody (VS-1224-YC392) is an anti-drug antibody (ADA) against Edrecolomab. This drug-based antibody is raised in mice immunized with the Edrecolomab. The anti-Edrecolomab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Edrecolomab in samples.
See other products for "EPCAM"
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-2219LY | Human Anti-EPCAM Recombinant Antibody (HPAB-2219LY) | ELISA | Human IgG |
| HPAB-2220LY | Human Anti-EPCAM Recombinant Antibody (HPAB-2220LY) | ELISA | Human IgG |
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| CAT | Product Name | Application | Type |
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| MRO-0538-CN | Mouse Anti-EPCAM Recombinant Antibody (clone 3-E1-E2) | WB, IF, IHC, FC | Mouse IgM |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2216LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2216LY-F(E)) | ELISA | Human Fab |
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| HPAB-2219LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2219LY-F(E)) | ELISA | Human Fab |
| HPAB-2220LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2220LY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2218LY-S(P) | Human Anti-EPCAM Recombinant Antibody; scFv Fragment (HPAB-2218LY-S(P)) | ELISA | Human scFv |
| HPAB-2219LY-S(P) | Human Anti-EPCAM Recombinant Antibody; scFv Fragment (HPAB-2219LY-S(P)) | ELISA | Human scFv |
| HPAB-2220LY-S(P) | Human Anti-EPCAM Recombinant Antibody; scFv Fragment (HPAB-2220LY-S(P)) | ELISA | Human scFv |
| HPAB-2221LY-S(P) | Human Anti-EPCAM Recombinant Antibody; scFv Fragment (HPAB-2221LY-S(P)) | ELISA | Human scFv |
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| VS-0325-XY773 | Anti-EPCAM Immunohistochemistry Kit | IHC | |
| VS-0525-XY2307 | Anti-Human EPCAM Immunohistochemistry Kit | IHC | |
| VS-0525-XY2308 | Anti-Mouse EPCAM Immunohistochemistry Kit | IHC | |
| VS-0525-XY2309 | Anti-Canine EPCAM Immunohistochemistry Kit | IHC |
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| CAT | Product Name | Application | Type |
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