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EPCAM

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This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG2a - kappa
Application:
ELISA, IP, FC, FuncS, IF, Neut
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1
Application:
WB, Neut, ELISA, IF, IP, FuncS, FC
Derivation:
Humanized (from mouse) Bispecific
Species Reactivity:
Human
Type:
(scFv - kappa - heavy) - (scFv - heavy - kappa)
Application:
IF, IP, Neut, FuncS, ELISA, FC, ICC
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1
Application:
WB, ELISA, IP, FC, FuncS, Neut, IF
Derivation:
Humanized
Species Reactivity:
Human
Type:
scFv - kappa - heavy
Application:
WB, Neut, ELISA, IF, IP, FuncS, FC
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
Fab - G1 - kappa
Application:
Neut, ELISA, IF, IP, FuncS, FC, ICC
Derivation:
Humanized
Species Reactivity:
Human
Type:
Antibody
Target:
EpCAM
Species Reactivity:
Human
Cytokine 1:
IL12
Host:
Humanized from Mouse
Cytokine 1 Species:
Mouse
Molecule Class:
L Kappa; IgG2a-IL12
Target:
EpCAM
Species Reactivity:
Human
Cytokine 1:
IL12
Host:
Human
Cytokine 1 Species:
Human
Molecule Class:
scFv-IL12
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, IHC, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
RIA, IF, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, IHC, FuncS
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Target:
EpCAM
Linker:
PEG4Mal
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
EpCAM
Linker:
SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
EpCAM
Linker:
SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
Drug:
DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
Target:
EpCAM
Species Reactivity:
Human
Cytokine 1:
IL12
Host:
Human
Cytokine 1 Species:
Mouse
Molecule Class:
IgG1-IL12
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