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EPCAM

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This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG2a - kappa
Application:
ELISA, IP, FC, FuncS, IF, Neut
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1
Application:
WB, Neut, ELISA, IF, IP, FuncS, FC
Derivation:
Humanized (from mouse) Bispecific
Species Reactivity:
Human
Type:
(scFv - kappa - heavy) - (scFv - heavy - kappa)
Application:
IF, IP, Neut, FuncS, ELISA, FC, ICC
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1
Application:
WB, ELISA, IP, FC, FuncS, Neut, IF
Derivation:
Humanized
Species Reactivity:
Human
Type:
scFv - kappa - heavy
Application:
WB, Neut, ELISA, IF, IP, FuncS, FC
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
Fab - G1 - kappa
Application:
Neut, ELISA, IF, IP, FuncS, FC, ICC
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, IHC, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
RIA, IF, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, IHC, FuncS
Targets:
EPCAM & CD3
Type:
BitE
Application:
FuncS, Promising therapeutic agent
Targets:
EPCAM & CD28
Type:
F(ab')2
Application:
FuncS, Promising therapeutic agent
Targets:
EPCAM & CD3
Type:
F(ab')2
Application:
FuncS, Promising therapeutic agent
Targets:
EpCAM & Ad fiber knob
Type:
F(ab')2
Application:
FuncS, Promising therapeutic agent
Targets:
EPCAM & CD3
Type:
TandAb
Application:
FuncS, Promising therapeutic agent
Targets:
CD28 & EPCAM
Type:
Triomab
Application:
FuncS, Promising therapeutic agent
Targets:
CD5 & EPCAM
Type:
Triomab
Application:
FuncS, Promising therapeutic agent
Targets:
EPCAM & CD3
Type:
Triomab
Application:
FuncS, Promising therapeutic agent
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
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