EPCAM
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, FC, IHC, IP, FuncS
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB, IHC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: Confocal, ELISA
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: NIR (Near-infrared) fluorescence imaging, ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Cytokine 2: GM-CSF
- Host: Human
- Cytokine 1 Species: Human
- Cytokine 2 Species: Human
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: NIR (Near-infrared) fluorescence imaging, ELISA
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- Type: Humanized antibody
- Application: Confocal, ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Cytokine 2: GM-CSF
- Host: Mouse
- Cytokine 1 Species: Mouse
- Cytokine 2 Species: Mouse
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: Confocal, ELISA
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, FuncS, Inhib, WB
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Type: Humanized antibody
- Application: Confocal, ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL4
- Cytokine 2: GM-CSF
- Host: Mouse
- Cytokine 1 Species: Mouse
- Cytokine 2 Species: Mouse
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL4
- Cytokine 2: GM-CSF
- Host: Mouse
- Cytokine 1 Species: Mouse
- Cytokine 2 Species: Mouse
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL4
- Cytokine 2: GM-CSF
- Host: Mouse
- Cytokine 1 Species: Human
- Cytokine 2 Species: Human
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: scIL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Mouse
- Cytokine 2 Species: Mouse
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, FuncS
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: scIL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Mouse
- Cytokine 2 Species: Mouse
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: ELISA
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Cytokine 2 Species: Human
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Mouse
- Cytokine 2 Species: Mouse
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: TNFα
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Mouse
- Cytokine 2 Species: Mouse
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: scIL12
- Host: Mouse
- Cytokine 1 Species: Mouse
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Cytokine 2 Species: Human
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: scIL12
- Host: Mouse
- Cytokine 1 Species: Mouse
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Cytokine 2 Species: Human
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: Cyt, ELISA, FC, WB
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2 (TTSR)
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Host: Mouse
- Cytokine 1 Species: Mouse
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2 (N88R)
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Application: ELISA, Inhib
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Host: Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2 (D20T)
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
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- Application: ELISA, Inhib
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Mouse
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2 (D20T)
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Application: ELISA, Inhib
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2 (D20T)
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Host: Human
- Cytokine 1 Species: Mouse
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: GM-CSF
- Host: Human
- Cytokine 1 Species: Human
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- Target: EpCAM
- Linker: sulfo-SPDB(sulfo-N-succinimidyl 4-(2-pyridyldithio)butyrate
- Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Host: Human
- Cytokine 1 Species: Human
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Target: EpCAM
- Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
- Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Host: Humanized from Mouse
- Cytokine 1 Species: Mouse
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- Target: EpCAM
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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- Target: EpCAM
- Linker: acid-cleavable hydrazone
linker
- Drug: Doxorubicin
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Target: EpCAM
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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- Target: EpCAM
- Linker: PEG4Mal
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
- Application: Cyt, FC
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Fab - G1 - kappa
- Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Humanized (from mouse) IgG1
- Application: WB, Neut, ELISA, IF, IP, FuncS, FC
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1
- Application: FC, IHC, FuncS, Inhib, Cyt
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG2a - kappa
- Application: ELISA, IP, FC, FuncS, IF, Neut
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