Human Anti-EpCAM (clone 3-171) scFv-Fc Chimera (CAT#: VS-0125-FY18)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Species Reactivity
• Human

• Clone
• 3-171

• Applications
• Cytotoxicity, ELISA, Flow Cytometry, Western Blot

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• No preservatives

• Stabilizer
• No Stabilizers

• Sterility
• 0.2 μM filtered

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The anti-EpCAM scFv-Fc can specifically recognize and bind to the EpCAM antigen, a surface antigen that is highly expressed on various tumor cells and possesses significant biomarker characteristics.

• Alternative Names
• Epithelial Cell Adhesion Molecule; Tumor-Associated Calcium Signal Transducer 1; Major Gastrointestinal Tumor-Associated Protein GA733-2; Adenocarcinoma-Associated Antigen; Cell Surface Glycoprotein Trop-1; Epithelial Glycoprotein 314; TACSTD1; EGP314; MIC18; TROP1; M4S1; KSA; Membrane Component, Chromosome 4, Surface Marker (35kD Glycoprotein); Antigen Identified By Monoclonal Antibody AUA1; Human Epithelial Glycoprotein-2; Epithelial Cell Surface Antigen

• Gene ID
• 4072

• UniProt ID
• P16422

• Sequence Similarities
• Belongs to the EPCAM family.

• Cellular Localization
• Cell junction, Cell membrane, Membrane, Tight junction

• Post Translation Modifications
• Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.

• Protein Refseq
• NP_002345.2

• Function
• May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

• TAB-356MZ
• Anti-Human EPCAM Recombinant Antibody (3-171)

• TAB-356MZ-S(P)
• Anti-Human EPCAM Recombinant Antibody scFv Fragment (3-171)

• TAB-356MZ-F(E)
• Anti-Human EPCAM Recombinant Antibody Fab Fragment (3-171)

• VS-1024-FY263
• Anti-EPCAM (clone 3-171) Recombinant Antibody Coupled Liposome (VS-1024-FY263)

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