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    anti-EPCAM immunotoxin MOC31 (IgG)-Bouganin (CAT#: AGTO-L013O)

    This immunotoxin was achieved by conjugating/fusing the Anti-EPCAM monoclonal antibody to Bouganin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to carcinoma cells. Once bind, the toxin enters cells by receptor-mediated endocytosis and enzymatically damages ribosomes, ultimately leading to cell death. It was designed for treatment of cancers.

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    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line MCF7
    Figure 1 IF staining of human cell line MCF7
    (Immunofluorescent staining of human cell line MCF7 shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67463/1592_H11_2_selected.jpg
    Normal Tissue
    Figure 2 Thyroid gland
    Figure 2 Thyroid gland
    (Glandular cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55098/120585_B_2_5.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Endocrine cells
    Staining: High
    Intensity: Strong
    Enterocytes
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Enterocytes - Microvilli
    Staining: High
    Intensity: Strong
    Goblet cells
    Staining: High
    Intensity: Strong
    Quantity:>75%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55098/120585_A_9_3.jpg
    Figure 4 Kidney
    Figure 4 Kidney
    (Collecting ducts
    Staining: High
    Intensity: Strong
    Quantity:>75%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55098/120585_A_8_5.jpg
    RNA Expression
    Figure 5 RNA cell line category: Cell line enhanced (A-431, CACO-2, CAPAN-2, OE19, RPTEC TERT1)
    Figure 5 RNA cell line category: Cell line enhanced (A-431, CACO-2, CAPAN-2, OE19, RPTEC TERT1)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000119888-EPCAM

    Specifications

    • Host Species
    • Mouse
    • Species Reactivity
    • Human
    • Clone
    • MOC31
    • Molecule Class
    • L kappa; IgG1-Bouganin
    • Toxin Description
    • Bouganin is a type-I ribosome inactivating protein (RIP) that was recently purified from leaves of Bougainvillea spectabilis Willd. Like all type-I RIPs, bouganin is a RNA glycosidase with deadenylating activity. Bouganin was characterized as a single-chain protein with a molecular mass of 26 200 Da and its mature protein consists of 250 amino acids. Furthermore, it was found that bouganin is probably the least toxic RIP known based on protein inhibiting studies in cell lines. It was observed that the bouganin concentrations inhibiting protein synthesis of human cell lines were much higher than the concentrations required to inhibit protein synthesis in a rabbit reticulocyte lysate assay, a characteristic common to all type-I RIPs.
    • Applications
    • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
    • Related Disease
    • Hepatocellular carcinomas (HCC)

    Target

    • Alternative Names
    • EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein); Hepatocellular carcinomas; HCC; Bouganin

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

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    Please select product type
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    CAT Product Name Application Type
    MOB-1093z Mouse Anti-EPCAM Recombinant Antibody (clone 41D5) WB, FC, IHC, IP, FuncS Mouse IgG1, κ
    HPAB-2219LY Human Anti-EPCAM Recombinant Antibody (HPAB-2219LY) ELISA Human IgG
    HPAB-2220LY Human Anti-EPCAM Recombinant Antibody (HPAB-2220LY) ELISA Human IgG
    HPAB-2221LY Human Anti-EPCAM Recombinant Antibody (HPAB-2221LY) ELISA Human IgG
    HPAB-2222LY Human Anti-EPCAM Recombinant Antibody (HPAB-2222LY) ELISA Human IgG

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