Rabbit Anti-FAS Recombinant Antibody (VS13-YC380)
CAT#: VS13-YC380
The Rabbit Anti-FAS Recombinant Antibody is specific for human FAS. FAS is part of the TNF-receptor superfamily, pivotal in apoptosis regulation through death domain interactions, associated with diseases like malignancies and immune disorders by forming signaling complexes that initiate caspase cascades. The anti-FAS antibody can be used for Western blot (1/500-1/2000), Immunocytochemistry (1/50-1/200), Immunofluorescence (1/50-1/200), Immunohistochemistry-paraffin (1/50-1/200).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nuclear bodies, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/546_F3_1_blue_red_green.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/61440_A_9_3.jpg
Normal Tissue
Figure 4 Testis
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/27444/61440_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000026103-FAS
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Specifications
- Immunogen
- Recombinant human Fas, aa 130-335.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human FAS
- Species Reactivity
- Human
- Applications
- WB, IHC-P, ICC, IF
- Conjugate
- NONE
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/2000
Immunocytochemistry (ICC): 1/50-1/200
Immunofluorescence (IF): 1/50-1/200
Immunohistochemistry-paraffin (IHC-P): 1/50-1/200
Target
- Alternative Names
- Fas Cell Surface Death Receptor; Tumor Necrosis Factor Receptor Superfamily, Member 6; Fas (TNF Receptor Superfamily, Member 6); Apoptosis-Mediating Surface Antigen FAS; TNF Receptor Superfamily Member 6; FASLG Receptor; CD95 Antigen; TNFRSF6; APT1; FAS1; Mutant Tumor Necrosis Receptor Superfamily Member 6;
- Gene ID
- 355
- UniProt ID
- P25445
- Long Name
- Fas Cell Surface Death Receptor
- Cellular Localization
- Secreted; Cell membrane
- Protein Refseq
- NP_000034.1; NP_001307548.1; NP_690610.1
- Function
- Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
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Related Signaling Pathways
TNF Signaling Pathway
Related Diseases
Allograft Rejection
Autoimmune Thyroid Disease
Graft-versus-Host Disease
Maturity Onset Diabetes of the Young
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "FAS"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-094 | Human Anti-FAS Recombinant Antibody (clone HFE7A); scFv Fragment | ELISA, WB, IF, FuncS | Human scFv |
| HPAB-0450-YJ-S(P) | Rabbit Anti-FAS Recombinant Antibody; scFv Fragment (HPAB-0450-YJ-S(P)) | ELISA, FC | Rabbit scFv |
| HPAB-0451-YJ-S(P) | Rabbit Anti-FAS Recombinant Antibody; scFv Fragment (HPAB-0451-YJ-S(P)) | ELISA, FC | Rabbit scFv |
| HPAB-1575WJ-S(P) | Mouse Anti-FAS Recombinant Antibody; scFv Fragment (clone F919-9-18) | ELISA, WB | Mouse scFv |
| HPAB-1576WJ-S(P) | Human Anti-FAS Recombinant Antibody; scFv Fragment (clone F919) | ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-094 | Human Anti-FAS Recombinant Antibody (clone HFE7A); Fab Fragment | ELISA, WB, IF, FuncS | Human Fab |
| PFBL-723 | Human Anti-FAS Recombinant Antibody (clone E09); Fab Fragment | WB, IF, FuncS | Human Fab |
| PFBL-724 | Human Anti-FAS Recombinant Antibody (clone EP6b-B01); Fab Fragment | WB, FuncS | Human Fab |
| HPAB-0035-YJ-F(E) | Human Anti-FAS Recombinant Antibody (clone h-HFE7A); Fab Fragment | ELISA, Cyt, Apop | Human Fab |
| HPAB-AP649-YC-F(E) | Human Anti-FAS Recombinant Antibody (clone F45D9-γ4); Fab Fragment | IHC, FC, ADCC, CDC, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-029WM | Anti-Human FAS Recombinant Antibody (F45D9-γ1) | FC | Human Antibody |
| TAB-029WM-S(P) | Anti-Human FAS Recombinant Antibody scFv Fragment (F45D9-γ1) | IHC, ELISA, FC | Human Antibody |
| TAB-029WM-F(E) | Anti-Human FAS Recombinant Antibody Fab Fragment (F45D9-γ1) | IHC, ELISA, FC | Human Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0201MZ | Chicken Anti-FAS (ab1) Polyclonal IgY | WB | Chicken antibody |
| BRD-0202MZ | Chicken Anti-FAS (ab2) Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-767CQ | Mouse Anti-FAS Recombinant Antibody (clone CBL933) | Neut, FC, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-768CQ | Mouse Anti-FAS Recombinant Antibody (clone ZB4) | Block, FC, IHC, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1252 | Hi-Affi™ Rabbit Anti-FAS Recombinant Antibody (clone DS1252AB) | WB, ICC | Rabbit IgG |
| MOR-1253 | Hi-Affi™ Rabbit Anti-Fas Recombinant Antibody (clone DS1253AB) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-103LC | Mouse Anti-FAS Recombinant Antibody (clone CH11) | FC, ICC, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-023LC | Mouse Anti-Fas Recombinant Antibody (clone YC084) | FC, ELISA | Mouse IgG1 |
| FN-038CQ | Mouse Anti-FAS Recombinant Antibody (clone APO-1-3) | FC, IP, WB, FuncS | Mouse IgG3 |
| ZG-0768F | Mouse Anti-FAS Recombinant Antibody (clone B-R18) | FC | Mouse IgG1 |
| ZG-0664J | Rabbit Anti-FAS Recombinant Antibody (clone 2B6) | ELISA, WB, IHC | Rabbit IgG |
| VS4-WK171 | Mouse Anti-FAS Recombinant Antibody (VS4-WK171) | ELISA, WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FN-213CQ | Mouse Anti-FAS Recombinant Antibody (clone EOS9.1) | FC, FuncS | Mouse IgM, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC127 | Human Anti-FAS Recombinant Antibody Hexamer (VS-0924-YC127), CDC Enhanced | IHC, FC, ADCC, CDC | Antibody hexamer |
| VS-0924-YC128 | Mouse Anti-FAS Recombinant Antibody Hexamer (VS-0924-YC128), CDC Enhanced | ELISA, WB, CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC348 | Recombinant Anti-FAS Vesicular Antibody, EV Displayed (VS-0425-YC348) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2448 | Anti-FAS Immunohistochemistry Kit | IHC | |
| VS-0525-XY2449 | Anti-Human FAS Immunohistochemistry Kit | IHC |
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