Rabbit Anti-FOLR1 Recombinant Antibody (clone R03-5I8) (CAT#: VS3-XY3360)
This antibody is a recombinant rabbit antibody targeting the FOLR1 (Folate receptor alpha), which has high affinity for folate and folic acid analogs at neutral pH. It specifically reacts with human, mouse and rat FOLR1. It has been reported for use in Western Blot. The recommended dilutions of Western Blot is 1/500-1/1000.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77030/1659_B3_2_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77030/1659_B3_2_selected.jpg
Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat FOLR1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R03-5I8
- Applications
- WB
- Related Disease
- Neurodegenerative Syndrome Due To Cerebral Folate Transport Deficiency
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
Target
- Alternative Names
- FBP; FOLR; NCFTD; FRalpha
- Gene ID
- 2348
- UniProt ID
- P15328
- Long Name
- Folate receptor alpha
- Cellular Localization
- Cell membrane, Cytoplasmic vesicle, Endosome
- Post Translation Modifications
- The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. (P15328-FOLR1_HUMAN)
Glycosylation at Asn69, Asn161, and Asn201 (NX_P15328 [NX_P15328-1])
Modification sites at PhosphoSitePlus (P15328)
Glycosylation from GlyConnect FOLR1_HUMAN (1248)
Glycosylation from GlyGen (P15328) 4 sites, 23 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- NP_000793.1; NP_057936.1
- Function
- Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:23851396, 23934049, 2527252, 8033114, 8567728, 19074442).
Has high affinity for folate and folic acid analogs at neutral pH (PubMed:23851396, 23934049, 2527252, 8033114, 8567728).
Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed:8567728).
Required for normal embryonic development and normal cell proliferation (By similarity).
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "FOLR1"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1297z | Mouse Anti-FOLR1 Recombinant Antibody (clone 24A8) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG2a |
| MOB-0624CT | Recombinant Mouse anti-Human FOLR1 Monoclonal antibody (ML37) | FC, ICC/IF, IHC-Fr, IP, WB | |
| HPAB-0080-FY | Human Anti-FOLR1 Recombinant Antibody (HPAB-0080-FY) | FC | Human IgG |
| HPAB-M0094-YC | Human Anti-FOLR1 Recombinant Antibody (HPAB-M0094-YC) | FuncS | Humanized IgG |
| VS3-CJ671 | Rabbit Anti-FOLR1 Recombinant Antibody (VS3-CJ671) | WB, IHC, FC | Rabbit IgG |
Intrabody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B029(A) | Recombinant Anti-human FOLR1 Intrabody [(D-Arg)9] | PCA, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B029(G) | Recombinant Anti-human FOLR1 Intrabody [+36 GFP] | WB, Neut, FuncS | scFv-(+36GFP) |
| IAB-B029(T) | Recombinant Anti-human FOLR1 Intrabody [Tat] | WB, ICC, Neut, FuncS | scFv-Tat |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-113 | Anti-Human folate receptor 1 Recombinant Antibody (Farletuzumab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | IgG1 - kappa |
| TAB-019CQ | Human Anti-FOLR1 Recombinant Antibody (TAB-019CQ) | ELISA, WB, IHC | Human IgG1, κ |
| TAB-019CQ-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-019CQ-S(P)) | ELISA, WB, IHC | Human scFv |
| TAB-019CQ-F(E) | Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-019CQ-F(E)) | ELISA, WB, IHC | Humanized Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-016CQ | Human Anti-FOLR1 Recombinant Antibody (TAB-016CQ) | ELISA, FC, WB | Human IgG |
| TAB-016CQ-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-016CQ-S(P)) | ELISA, FC, WB | Human scFv |
| TAB-016CQ-F(E) | Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-016CQ-F(E)) | ELISA, FC, WB | Human Fab |
| TAB-382CQ | Anti-Human FOLR1 Recombinant Antibody (KHK2805) | IHC | Human antibody |
| TAB-382CQ-S(P) | Anti-Human FOLR1 Recombinant Antibody scFv Fragment (KHK2805) | IHC | Human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-017CQ | Rat Anti-FOLR1 Recombinant Antibody (TAB-017CQ) | ELISA, WB, IHC | Rat IgG1, κ |
| TAB-020CQ | Mouse Anti-FOLR1 Recombinant Antibody (TAB-020CQ) | ELISA, FC, WB, IHC | Mouse IgG1 |
| TAB-017CQ-S(P) | Rat Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-017CQ-S(P)) | ELISA, WB, IHC | Rat scFv |
| TAB-017CQ-F(E) | Rat Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-017CQ-F(E)) | ELISA, WB, IHC | Rat Fab |
| TAB-020CQ-F(E) | Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-020CQ-F(E)) | ELISA, FC, WB, IHC | Mouse Fab |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-018CQ | Human Anti-FOLR1 Recombinant Antibody (TAB-018CQ) | ELISA, WB, IHC | Chimeric (Rat/Human) IgG1, κ |
| TAB-018CQ-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-018CQ-S(P)) | ELISA, WB, IHC | Human scFv |
| TAB-018CQ-F(E) | Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-018CQ-F(E)) | ELISA, WB, IHC | Chimeric (Rat/Human) Fab |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-029LC | Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
| Gly-030LC | Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation) | ELISA | Human antibody |
| Gly-116LC | Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation) | ELISA | Human antibody |
Low- or Non-fucosylated Oligosaccharide
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-029LC-1 | Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1333 | Hi-Affi™ Rabbit Anti-FOLR1 Recombinant Antibody (clone DS1333AB) | WB | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0115-CN-F(E) | Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0115-CN-F(E)) | ELISA, FC, IHC | Mouse Fab |
| HPAB-0116-CN-F(E) | Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0116-CN-F(E)) | ELISA, FC, IHC | Humanized Fab |
| HPAB-0117-CN-F(E) | Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0117-CN-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0118-CN-F(E) | Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0118-CN-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0119-CN-F(E) | Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0119-CN-F(E)) | ELISA, FC, IHC, WB | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0080-FY-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-0080-FY-S(P)) | FC | Human scFv |
| HPAB-0312-WJ-S(P) | Mouse Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-0312-WJ-S(P)) | ELISA, IHC, FC | Mouse scFv |
| HPAB-0313-WJ-S(P) | Mouse Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-0313-WJ-S(P)) | ELISA, IHC, FC | Mouse scFv |
| HPAB-0314-WJ-S(P) | Mouse Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-0314-WJ-S(P)) | ELISA, IHC, FC | Mouse scFv |
| HPAB-M0094-YC-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-M0094-YC-S(P)) | FuncS | Humanized scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-113 | Afuco™ Anti-FOLR1 ADCC Recombinant Antibody (Farletuzumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0049 | APC-A*02:01/Human FBP (EIWTHSYKV) MHC Tetramer | FCM | |
| MHC-CN0685 | PE-A*02:01/Human FOLR1 (EIWTHSYKV) MHC Tetramer | FCM, IHC | |
| MHC-CN0686 | APC-A*02:01/Human FOLR1 (EIWTHSYKV) MHC Tetramer | FCM, IHC | |
| MHC-CN0687 | FITC-A*02:01/Human FOLR1 (EIWTHSYKV) MHC Tetramer | FCM, IHC | |
| MHC-CN0688 | A*02:01/Human FOLR1 (EIWTHSYKV) MHC Tetramer | FCM, IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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