Anti-PDCD1 (clone PD1-17) Recombinant Antibody Coupled Liposome (VS-1024-FY255)
CAT#: VS-1024-FY255
Anti-PD-1 antibody conjugated liposomes hold significant potential in the treatment of Adrenocortical carcinoma by enhancing the immune response against tumor cells. By targeting the PD-1 immune checkpoint pathway, these liposomes could improve T-cell activation and promote antitumor immunity, potentially leading to better patient outcomes. Additionally, the liposomal delivery system can enhance the bioavailability and stability of the conjugated antibodies, ensuring sustained therapeutic effects at the tumor site. Overall, this innovative approach may pave the way for more effective immunotherapies in combating Adrenocortical carcinoma and other malignancies.
Gene Expression
Normal Tissue
Figure 1 Lymph node
Germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35981/161493_A_9_8.jpg
Normal Tissue
Figure 2 Tonsil
Germinal center cells
Staining:
High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35981/161493_A_6_8.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000188389-PDCD1
❮
❯
More Infomation
Specifications
- Potential Clinical Applications
- Adrenocortical carcinoma
Product Composition
- Clone
- PD1-17
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that was engineered to specifically bind to Programmed Cell Death Protein 1 (PD-1), an important checkpoint inhibitor in the immune system. The antibody's high affinity and specificity towards PD-1 make it a powerful tool in immunological research and therapeutic development, particularly in the context of cancer treatment. By blocking PD-1 interactions, this antibody can potentially restore immune responses against tumors, thus playing a pivotal role in cancer immunotherapy.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- PDCD1
- Introduction
- This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
- Alternative Names
- Programmed Cell Death 1; Systemic Lupus Erythematosus Susceptibility 2; Protein PD-1; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1
- Full Name
- Programmed Cell Death 1
- Gene ID
- 5133
- UniProt ID
- Q15116
- Cellular Localization
- Cell membrane; Membrane
- Post Translation Modifications
- Ubiquitinated at Lys-233 by the SCF(FBXO38) complex, leading to its proteasomal degradation (PubMed:30487606).
Ubiquitinated via 'Lys-48'-linked polyubiquitin chains (PubMed:30487606).
Tyrosine phosphorylated at Tyr-223 (within ITIM motif) and Tyr-248 (ITSM motif) upon ligand binding. Phosphorylation at Tyr-248 promotes the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta.
N-glycosylation at Asn-58 contains at least two N-acetylglucosamine units and one fucose (PubMed:28165004).
- Protein Refseq
- NP_005009.2
- Function
- Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005).
Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005).
Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity).
Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity).
The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28951311).
The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed:28951311).
The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed:22658127, PubMed:25034862, PubMed:25399552).
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-1024-FY255. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone PD1-17"
- CAT
- Product Name
See other products for "PDCD1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1201z | Mouse Anti-PDCD1 Recombinant Antibody (clone 27G11) | ELISA, FC, ICC, IF, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-900 | Anti-Human PD-1/PDCD1/CD279 Recombinant Antibody (TAB-900) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H55 | Human Anti-PDCD1 Recombinant Antibody (TAB-H55) | Inhib, Agonist | IgG4, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-770 | Anti-PDCD1 Recombinant Antibody (TAB-770) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG4 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-295 | Human Anti-PDCD1 Recombinant Antibody (clone CBL12Q) | WB, ELISA, FuncS | Human IgG4 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-295 | Human Anti-PDCD1 Recombinant Antibody (clone CBL42Q); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-295 | Human Anti-PDCD1 Recombinant Antibody (clone CBL27Q); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0961CL | Anti-Human PDCD1 Recombinant Antibody (PD1-17) | ELISA, FuncS | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0962CL | Anti-Mouse Pdcd1 Recombinant Antibody (PD1-F2) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0963CL | Mouse Anti-PDCD1 Recombinant Antibody (TAB-0963CL) | FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0964CL | Mouse Anti-PDCD1 Recombinant Antibody (TAB-0964CL) | ELISA, Inhib | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0965CL | Mouse Anti-PDCD1 Recombinant Antibody (TAB-0965CL) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0966CL | Human Anti-PDCD1 Recombinant Antibody (TAB-0966CL) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0967CL | Anti-Human PDCD1 Recombinant Antibody (AB7) | ELISA, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0968CL | Anti-Human PDCD1 Recombinant Antibody (cAB7) | ELISA, WB | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0969CL | Mouse Anti-PDCD1 Recombinant Antibody (TAB-0969CL) | FC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0970CL | Human Anti-PDCD1 Recombinant Antibody (TAB-0970CL) | ELISA, FuncS | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0971CL | Human Anti-PDCD1 Recombinant Antibody (TAB-0971CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0974CL | Human Anti-PDCD1 Recombinant Antibody (TAB-0974CL) | ELISA | Chimeric (Mouse/Human) antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0975CL | Human Anti-PDCD1 Recombinant Antibody (TAB-0975CL) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0977CL | Anti-Human PDCD1 Recombinant Antibody (949gH1a) | FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0968CL-S(P) | Anti-Human PDCD1 Recombinant Antibody scFv Fragment (cAB7) | ELISA, WB | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0974CL-S(P) | Human Anti-PDCD1 Recombinant Antibody; scFv Fragment (TAB-0974CL-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0968CL-F(E) | Anti-Human PDCD1 Recombinant Antibody Fab Fragment (cAB7) | ELISA, WB | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1298CT | Recombinant Mouse anti-Human PDCD1 Monoclonal antibody (NJI5) | FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1827CQ | Recombinant Rat Anti-Pdcd1 Antibody (29F.1A12) | BL, FC | IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1828CQ | Recombinant Hamster Anti-Pdcd1 Antibody (J43) | BL, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1829CQ | Recombinant Rat Anti-Pdcd1 Antibody (RMP1-14) | BL, WB | IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1830CQ | Recombinant Rat Anti-Pdcd1 Antibody (NEUT-1830CQ) | BL | IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1831CQ | Recombinant Hamster Anti-Pdcd1 Antibody (MAB0839) | BL, FC | IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1832CQ | Recombinant Mouse Anti-PDCD1 Antibody (CBL151) | Neut, WB | IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1834CQ | Recombinant Human Anti-PDCD1 Antibody (CBL1021) | Neut | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1835CQ | Recombinant Mouse Anti-PDCD1 Antibody (9X21) | Neut, WB | IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2622 | Hi-Affi™ Recombinant Rabbit Anti-PDCD1 Monoclonal Antibody (DS2622AB) | IHC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0184-YC | Mouse Anti-PDCD1 Recombinant Antibody (HPAB-0184-YC) | FC, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0185-YC | Mouse Anti-PDCD1 Recombinant Antibody (HPAB-0185-YC) | FC, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0184-YC-S(P) | Mouse Anti-PDCD1 Recombinant Antibody; scFv Fragment (HPAB-0184-YC-S(P)) | FC, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0185-YC-S(P) | Mouse Anti-PDCD1 Recombinant Antibody; scFv Fragment (HPAB-0185-YC-S(P)) | FC, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0186-YC-S(P) | Mouse Anti-PDCD1 Recombinant Antibody; scFv Fragment (HPAB-0186-YC-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0187-YC-S(P) | Human Anti-PDCD1 Recombinant Antibody; scFv Fragment (HPAB-0187-YC-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0184-YC-F(E) | Mouse Anti-PDCD1 Recombinant Antibody; Fab Fragment (HPAB-0184-YC-F(E)) | FC, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0185-YC-F(E) | Mouse Anti-PDCD1 Recombinant Antibody; Fab Fragment (HPAB-0185-YC-F(E)) | FC, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0186-YC-F(E) | Mouse Anti-PDCD1 Recombinant Antibody; Fab Fragment (HPAB-0186-YC-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0187-YC-F(E) | Human Anti-PDCD1 Recombinant Antibody; Fab Fragment (HPAB-0187-YC-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-900 | Afuco™ Anti-PDCD1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-900) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-028ML | Afuco™ Anti-PDCD1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-028ML) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-012ML | Afuco™ Anti-PDCD1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-012ML) | ELISA, IHC, FC, IP, IF, BL | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-770 | Afuco™ Anti-PDCD1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-770) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H55 | Afuco™ Human Anti-PDCD1 Recombinant Antibody, ADCC Enhanced (AFC-TAB-H55) | FuncS, IF, Neut, ELISA, FC | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0252-WJ | Rat Anti-PDCD1 Recombinant Antibody (HPAB-0252-WJ) | ELISA | Rat IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0309-YC-VHH | Recombinant Humanized Anti-PDCD1 Single Domain Antibody (HPAB-N0309-YC-VHH) | FC, ELISA | Humanized VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY39 | Rabbit Anti-PDCD1 Agonistic Antibody (VS-0724-XY39) | ELISA, Agonistic assays | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY59 | Human Anti-PDCD1 Agonistic Antibody (clone 949) | ELISA, BLI, FC, Agonistic assays | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1287 | AbPlus™ Anti-PDCD1 Magnetic Beads (VS-0724-YC1287) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC141 | Human Anti-PDCD1 Recombinant Antibody Hexamer (VS-0924-YC141), CDC Enhanced | IP, IF, FuncS, FC, Neut, ELISA, CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC142 | Mouse Anti-PDCD1 Recombinant Antibody Hexamer (VS-0924-YC142), CDC Enhanced | ELISA, Block, CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY87 | Mouse Anti-NHP PDCD1 Recombinant Antibody (clone EH12.2H7) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY34 | Human Anti-PDCD1 (clone PD1-17) scFv-Fc Chimera | ELISA, FuncS, Block, ADCC, CDC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY173 | CytoStream™ Mouse Anti-PDCD1 Recombinant Antibody (VS-0225-XY173) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC457 | Recombinant Anti-PDCD1 Vesicular Antibody, EV Displayed (VS-0425-YC457) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5251 | Anti-PDCD1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5252 | Anti-Mouse PDCD1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC224 | Recombinant Anti-PDCD1 (AA 25-34 x AA 74-99) Biparatopic Antibody, Tandem scFv | ELISA | Tandem scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC19 | SmartAb™ Recombinant Anti-PDCD1 pH-dependent Antibody (VS-0825-YC19) | IF, IP, Neut, ELISA, FC, ICC | Human IgG4 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC278 | SmartAb™ Recombinant Anti-PDCD1 pH-dependent Antibody (VS-0825-YC278) | ELISA, ICC, IP, IF, FC, Neut | Human IgG1 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1025-YC76 | Anti-PDCD1 Antibody Prodrug, Protease Activated (VS-1025-YC76) | ISZ, Cyt, FuncS |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY818 | Mouse Anti-PDCD1 Recombinant Antibody (VS-1125-XY818) | IHC, FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY819 | Mouse Anti-PDCD1 Recombinant Antibody (VS-1125-XY819) | IHC, FC, IP | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY820 | Mouse Anti-PDCD1 Recombinant Antibody (VS-1125-XY820) | WB, IHC, ICC, IF | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY821 | Mouse Anti-PDCD1 Recombinant Antibody (VS-1125-XY821) | WB, IHC, ICC, IF | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY822 | Mouse Anti-PDCD1 Recombinant Antibody (VS-1125-XY822) | WB, IHC, ICC, IF | Mouse IgG2a |
See Our Custom Production in Action
Popular Products
Application: FC, Cyt, Stim, PP, Agonist
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: WB, Neut, ELISA, IF, IP, FuncS, FC
Application: ELISA, Neut, FuncS
Application: ELISA, SPR, Inhib, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
