Anti-PDCD1 (clone PD1-17) Recombinant Antibody Coupled Liposome (VS-1024-FY255) (CAT#: VS-1024-FY255)

• Potential Clinical Applications
• Adrenocortical carcinoma

• Clone
• PD1-17

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant mouse monoclonal antibody that was engineered to specifically bind to Programmed Cell Death Protein 1 (PD-1), an important checkpoint inhibitor in the immune system. The antibody's high affinity and specificity towards PD-1 make it a powerful tool in immunological research and therapeutic development, particularly in the context of cancer treatment. By blocking PD-1 interactions, this antibody can potentially restore immune responses against tumors, thus playing a pivotal role in cancer immunotherapy.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• PDCD1

• Introduction
• This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.

• Alternative Names
• Programmed Cell Death 1; Systemic Lupus Erythematosus Susceptibility 2; Protein PD-1; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1

• Full Name
• Programmed Cell Death 1

• Gene ID
• 5133

• UniProt ID
• Q15116

• Cellular Localization
• Cell membrane; Membrane

• Post Translation Modifications
• Ubiquitinated at Lys-233 by the SCF(FBXO38) complex, leading to its proteasomal degradation (PubMed:30487606).
  Ubiquitinated via 'Lys-48'-linked polyubiquitin chains (PubMed:30487606).
  Tyrosine phosphorylated at Tyr-223 (within ITIM motif) and Tyr-248 (ITSM motif) upon ligand binding. Phosphorylation at Tyr-248 promotes the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta.
  N-glycosylation at Asn-58 contains at least two N-acetylglucosamine units and one fucose (PubMed:28165004).

• Protein Refseq
• NP_005009.2

• Function
• Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005).
  Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005).
  Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity).
  Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity).
  The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28951311).
  The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed:28951311).
  The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed:22658127, PubMed:25034862, PubMed:25399552).

• TAB-0961CL
• Anti-Human PDCD1 Recombinant Antibody (PD1-17)

• TAB-0961CL-S(P)
• Anti-Human PDCD1 Recombinant Antibody scFv Fragment (PD1-17)

• TAB-0961CL-F(E)
• Anti-Human PDCD1 Recombinant Antibody Fab Fragment (PD1-17)

• VS-0125-FY34
• Human Anti-PDCD1 (clone PD1-17) scFv-Fc Chimera

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