Anti-Human PDCD1 Recombinant Antibody Fab Fragment (PD1-17)

Name: Anti-Human PDCD1 Recombinant Antibody Fab Fragment (PD1-17)
SKU: TAB-0961CL-F(E)
Rating: 5 (1 reviews)

CAT#: TAB-0961CL-F(E)

This antibody can inhibit binding of PD-L1 to PD-1 and modulate immune responses mediated by TcR and CD28, in particular. It may be used in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.

Tested Data Gene Expression

SDS-PAGE

Figure 1 Anti-Human PDCD1 Recombinant Antibody Fab Fragment (PD1-17), gggc tag (TAB-0961CL-F(E)) in SDS-PAGE

Lane 1: Reduced Fab
Lane 2: Non-reduced Fab

Figure 2 Anti-Human PDCD1 Recombinant Antibody Fab Fragment (PD1-17), gggc tag (TAB-0961CL-F(E)) in WB

Western blot analysis of TAB-0961CL-F(E) was performed by loading Recombinant Human PD-1 Protein (ECD, His Tag).

TAB-0961CL-F(E) incubation concentration: 2 ng/μL.
The secondary antibody: HRP-Anti-human IgG antibody
Lane 1: Reducing Antigen (0.1 μg)
Lane 2: Reducing Antigen (0.3 μg)
Lane 3: Reducing Antigen (0.6 μg)

Figure 3 Anti-Human PDCD1 Recombinant Antibody Fab Fragment (PD1-17), gggc tag (TAB-0961CL-F(E)) in DB

Dot Blot analysis of TAB-0961CL-F(E) was performed by coating with Recombinant Human PD-1 Protein (ECD, His Tag).

The secondary antibody: HRP-Anti-human IgG antibody

❮

❯

Normal Tissue Figure 1 Lymph node

Germinal center cells
Staining:

Medium

Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35981/161493_A_9_8.jpg

Normal Tissue Figure 2 Tonsil

Germinal center cells
Staining:

High

Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:

Medium

Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35981/161493_A_6_8.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4, RPMI-8226)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000188389-PDCD1

❮

❯

Specifications

Immunogen
Soluble PD-1 fusion protein

Host Species
Human

Derivation
scFv phagemid library

Type
Human antibody

Specificity
Human

Clone
PD1-17

Applications
ELISA

Related Disease
Rheumatoid arthritis (RA)

Target

Alternative Names
PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2

Gene ID
5133

UniProt ID
Q15116

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Citations

Chen, Yundi, et al. "Engineered extracellular vesicles for concurrent Anti-PDL1 immunotherapy and chemotherapy." Bioactive materials 9 (2022): 251-265. https://doi.org/10.1016/j.bioactmat.2021.07.012

This research focuses on engineered extracellular vesicles (EVs) for concurrent immunotherapy and chemotherapy targeting cancer. The study developed EVs that overexpress high-affinity variant PD-1 protein (havPD-1) while simultaneously knocking out PD-L1 and beta-2 microglobulin in donor cells. These engineered havPD-1 EVs demonstrated multiple therapeutic effects: they reduced PD-L1+ cancer cell proliferation, induced cellular apoptosis, efficiently blocked PD-L1 mediated T cell suppression, and showed robust anti-tumor activity in xenograft models. Furthermore, the researchers enhanced therapeutic efficacy by loading the EVs with PARP inhibitors, creating a dual-action delivery system that combines immune checkpoint inhibition with targeted chemotherapy.
Creative Biolabs provided anti-PD-1 antibody Fab fragments (TAB-0961CL-F(E)) for the study. These antibody fragments were crucial for characterizing and quantifying havPD-1 molecules on the EV surface through immunogold labeling techniques. This contribution enabled precise visualization and estimation of havPD-1 protein density on the engineered EVs, which was essential for understanding the relationship between havPD-1 expression levels and the therapeutic efficacy of these novel drug delivery vehicles against cancer cells.

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(Creative Biolabs Cat# TAB-0961CL-F(E), RRID: AB_3111802)

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-0961CL-F(E).pdf

MSDS

MSDS - TAB-0961CL-F(E).pdf

COA

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