Anti-Human PDCD1 Recombinant Antibody Fab Fragment (PD1-17) (CAT#: TAB-0961CL-F(E))
This antibody can inhibit binding of PD-L1 to PD-1 and modulate immune responses mediated by TcR and CD28, in particular. It may be used in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
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SDS-PAGE
-YJ-1.jpg)
Figure 1 Anti-Human PDCD1 Recombinant Antibody Fab Fragment (PD1-17), gggc tag (TAB-0961CL-F(E)) in SDS-PAGE
Lane 1: Reduced Fab
Lane 2: Non-reduced Fab
WB
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Figure 2 Anti-Human PDCD1 Recombinant Antibody Fab Fragment (PD1-17), gggc tag (TAB-0961CL-F(E)) in WB
Western blot analysis of TAB-0961CL-F(E) was performed by loading Recombinant Human PD-1 Protein (ECD, His Tag).
TAB-0961CL-F(E) incubation concentration: 2 ng/μL.
The secondary antibody: HRP-Anti-human IgG antibody
Lane 1: Reducing Antigen (0.1 μg)
Lane 2: Reducing Antigen (0.3 μg)
Lane 3: Reducing Antigen (0.6 μg)
DB
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Figure 3 Anti-Human PDCD1 Recombinant Antibody Fab Fragment (PD1-17), gggc tag (TAB-0961CL-F(E)) in DB
Dot Blot analysis of TAB-0961CL-F(E) was performed by coating with Recombinant Human PD-1 Protein (ECD, His Tag).
The secondary antibody: HRP-Anti-human IgG antibody
Specifications
- Immunogen
- Soluble PD-1 fusion protein
- Host Species
- Human
- Derivation
- scFv phagemid library
- Type
- Human antibody
- Specificity
- Human
- Clone
- PD1-17
- Applications
- ELISA
- Related Disease
- Rheumatoid arthritis (RA)
Target
- Alternative Names
- PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2
- Gene ID
- 5133
- UniProt ID
- Q15116
Related Resources
Chen, Yundi, et al. "Engineered extracellular vesicles for concurrent Anti-PDL1 immunotherapy and chemotherapy." Bioactive materials 9 (2022): 251-265. https://doi.org/10.1016/j.bioactmat.2021.07.012
This research focuses on engineered extracellular vesicles (EVs) for concurrent immunotherapy and chemotherapy targeting cancer. The study developed EVs that overexpress high-affinity variant PD-1 protein (havPD-1) while simultaneously knocking out PD-L1 and beta-2 microglobulin in donor cells. These engineered havPD-1 EVs demonstrated multiple therapeutic effects: they reduced PD-L1+ cancer cell proliferation, induced cellular apoptosis, efficiently blocked PD-L1 mediated T cell suppression, and showed robust anti-tumor activity in xenograft models. Furthermore, the researchers enhanced therapeutic efficacy by loading the EVs with PARP inhibitors, creating a dual-action delivery system that combines immune checkpoint inhibition with targeted chemotherapy.
Creative Biolabs provided anti-PD-1 antibody Fab fragments (TAB-0961CL-F(E)) for the study. These antibody fragments were crucial for characterizing and quantifying havPD-1 molecules on the EV surface through immunogold labeling techniques. This contribution enabled precise visualization and estimation of havPD-1 protein density on the engineered EVs, which was essential for understanding the relationship between havPD-1 expression levels and the therapeutic efficacy of these novel drug delivery vehicles against cancer cells.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1201z | Mouse Anti-PDCD1 Recombinant Antibody (clone 27G11) | ELISA, FC, ICC, IF, IHC | Mouse IgG1 |
| PABL-295 | Human Anti-PDCD1 Recombinant Antibody (clone CBL12Q) | WB, ELISA, FuncS | Human IgG4 kappa |
| HPAB-0517LY | Human Anti-PDCD1 Recombinant Antibody (clone MIL75) | ELISA, Block | Human IgG1 |
| HPAB-0518LY | Human Anti-PDCD1 Recombinant Antibody (clone CBL011LY) | ELISA, Block | Human IgG1 |
| HPAB-0519LY | Mouse Anti-PDCD1 Recombinant Antibody (clone 1D2) | ELISA, Block | Mouse IgG |
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To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-0961CL-F(E), RRID: AB_3111802)
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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