Anti-TNFRSF9 Recombinant Antibody (VS-0724-YC48) (CAT#: VS-0724-YC48)
These antibodies are recombinant mAbs against human TNFRSF9, also known as 4-1BB. Both B1E7 and B1A7 effectively block the epitope of 4-1BBL, while B1E10 cannot block the binding to 4-1BBL. B1E7, B1A7 and B1E10 are murine antibody clones. chB1E7 and chB1E10 are chimeirc antibodies that contains B1E7 or B1E10 variable region and human IgG Fc region. huB1E7 and huB1E10 are humanized antibodies derived from parent B1E7and B1E10, respectively.
| Sub Cat | Clone | Host Animal | Applications | Derivation | Type | Affinity Constant | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS-0724-YC49 | B1E7 | Mouse | ELISA, Block, FuncS | Hybridoma | Mouse IgG | |||||||
| VS-0724-YC50 | B1A7 | Mouse | ELISA, Block, FuncS | Hybridoma | Mouse IgG | |||||||
| VS-0724-YC51 | B1E10 | Mouse | ELISA, FuncS | Hybridoma | Mouse IgG | |||||||
| VS-0724-YC52 | chB1E7 | Human | ELISA, Block, FuncS | Chimeric (mouse/human) | Human IgG1 | KD = 1.48 nM | ||||||
| VS-0724-YC53 | huB1E7 | Human | ELISA, Block, FuncS | Humanized | Human IgG1 | KD = 1.95 nM | ||||||
| VS-0724-YC54 | chB1E10 | Human | ELISA, FuncS | Chimeric (mouse/human) | Human IgG1 | KD = 0.42 nM | ||||||
| VS-0724-YC55 | huB1E10 | Human | ELISA, FuncS | Humanized | Human IgG1 | KD = 0.26 nM |
More Infomation
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71425/1522_F4_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71425/1522_F4_1_selected.jpg
Figure 2 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000049249-TNFRSF9
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000049249-TNFRSF9
Specifications
- Immunogen
- Recombinant human 4-1BB protein with Fc tag
- Specificity
- Human TNFRSF9
- Species Reactivity
- Human
- Applications
- ELISA, Block, FuncS
Product Property
- Purification
- Protein G purified
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- ILA; 4-1BB; CD137; CDw137; IMD109
- Gene ID
- 3604
- UniProt ID
- Q07011
- Long Name
- TNF receptor superfamily member 9
- Cellular Localization
- Cell membrane; Single-pass type I membrane protein
- Post Translation Modifications
- Glycosylation at Asn138 and Asn149.
Ubiquitination at Lys219.
- Protein Refseq
- XP_006710681.1; XP_047275628.1; XP_054192390.1; XP_054192391.1; NP_001552.2
- Function
- Cell membrane; Single-pass type I membrane protein
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-179 | Anti-Human 4-1BB Recombinant Antibody (TAB-179) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG4 - kappa |
| TAB-457CQ | Anti-Human TNFRSF9 Recombinant Antibody (TAB-457CQ) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, λ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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