Anti-CD70 (clone h1F6239C)-PBD ADC (CAT#: ADC-135LZY)
This ADC product is composed of an anti-CD70 antibody (clone h1F6239C) conjugated via linker to PBD (h1F6239C-PBD). It has demonstrated a response in renal cell carcinoma (RCC) treatment by a MOA (Mechanism of Action) of crosslinking DNA and interrupting cell division.
Specific Inquiry
Subcellular Location and Protein Expression
RNA Expression
Figure 1 IF staining of human cell line SiHa
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg
Figure 3 RNA cell line category: Cell line enhanced (SiHa, THP-1, U-251 MG, U-266/70, U-266/84, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
Specifications
- Antibody Overview
- h1F6239C(the h1F6 is engineered
with a Cysteine residue at position 239 of the Heavy chain)
- Clone
- h1F6239C
- Antibody Isotype
- IgG1
- Linker
- maleimidocaproyl-valine-alanine
- Drug
- pyrrolobenzodiazepine (PBD) dimers
- Drug Class/Description
- Class: pyrrolobenzodiazepine (PBD) dimers
Description: Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.
Target
- Introduction
- The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
- Alternative Names
- CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;
- Gene ID
- 970
- UniProt ID
- P32970
Downloads
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Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-336LC | Anti-Human CD70 Recombinant Antibody (Mb VLVH) | ELISA, FC, WB | Human antibody |
| TAB-337LC | Anti-Human CD70 Recombinant Antibody (Mb VHVL) | ELISA, FC, WB | Human antibody |
| TAB-338LC | Anti-Human CD70 Recombinant Antibody (VL-5-VH) | FC, WB | Human antibody |
| TAB-339LC | Anti-Human CD70 Recombinant Antibody (VH-5-VL) | FC, WB | Human antibody |
| TAB-340LC | Anti-Human CD70 Recombinant Antibody (VL-8-VH) | FC, WB | Human antibody |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-335LC-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-335LC-S(P)) | ELISA | Humanized scFv |
| TAB-342LC-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-342LC-S(P)) | FC | Humanized scFv |
| TAB-343LC-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-343LC-S(P)) | FC | Humanized scFv |
| TAB-344LC-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-344LC-S(P)) | FC | Human scFv |
| TAB-335LC-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-335LC-F(E)) | ELISA | Humanized Fab |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-403CQ | Rat Anti-Cd70 Recombinant Antibody (clone 9G24) | ELISA, Neut | Rat IgG1 |
| NEUT-405CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL684) | ELISA, Neut | Rat IgG1 |
| NEUT-406CQ | Rat Anti-Cd70 Recombinant Antibody (clone FR70) | FC, FuncS, Neut, IP | Rat IgG2b, κ |
| NEUT-407CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL856) | ELISA, Neut | Rat IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-404CQ | Rat Anti-Cd70 Recombinant Antibody (clone MAB0825) | Block, FC, Inhib, IP | Rat IgG2 |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0095-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0095-LSX) | ELISA, FC, ADCC, FuncS | Human IgG |
| HPAB-0096-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0096-LSX) | ELISA, FC, Block, FuncS | Human IgG |
| FN-046CQ | Mouse Anti-CD70 Recombinant Antibody (clone BU69) | ELISA, FC, Block, ICC, IHC | Mouse IgG1 |
| FAMAB-1735CQ | Mouse Anti-CD70 Recombinant Antibody (clone TAN 1-7) | Block, ELISA, FC, IF | Mouse IgG2a |
| FAMAB-1763CQ | Mouse Anti-CD70 Recombinant Antibody (clone TAN1-6) | Block, WB, FC, IF | Mouse IgG2a |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H76 | Afuco™ Anti-CD70 ADCC Recombinant Antibody (Vorsetuzumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0468-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0468-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0469-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0469-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0470-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0470-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0471-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0471-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0472-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0472-WJ-F(E)) | ELISA | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0468-WJ-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0468-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0469-WJ-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0469-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0470-WJ-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0470-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0471-WJ-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0471-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0472-WJ-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0472-WJ-S(P)) | ELISA | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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