Anti-CD70 (clone h1F6239C)-PBD ADC (CAT#: ADC-135LZY)

• Antibody Overview
• h1F6239C(the h1F6 is engineered
  with a Cysteine residue at position 239 of the Heavy chain)

• Clone
• h1F6239C

• Antibody Isotype
• IgG1

• Linker
• maleimidocaproyl-valine-alanine

• Drug
• pyrrolobenzodiazepine (PBD) dimers

• Drug Class/Description
• Class: pyrrolobenzodiazepine (PBD) dimers
  Description: Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.

• Introduction
• The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

• Alternative Names
• CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;

• Gene ID
• 970

• UniProt ID
• P32970

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