Anti-CanAg (huC242)-SMCC-DM1 ADC (CAT#: ADC-009LCT)

This ADC product is composed of an anti-CanAg antibody (clone huC242) conjuagated via a SMCC linker to DM1 (huC242-SMCC-DM1). It has demonstrated a response in CanAg-positive tumors treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Humanized Antibody, huC242 (Anti-CanAg)
  • Clone
  • huC242
  • Antibody Isotype
  • IgG1
  • Linker
  • SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
  • Linker Class/Description
  • Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
  • Drug
  • DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
  • Drug Class/Description
  • Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

Target

  • Introduction
  • The CanAg tumour antigen is a novel glycoform of MUC1.
  • Alternative Names
  • MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-6; mucin 1, transmembrane; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen; Medullary cystic kidney disease, autosomal dominant;

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Humanized Antibody

CAT Product Name Application Type
TAB-173 Anti-Human MUC1 Recombinant Antibody (Cantuzumab Ravtansine) IF, IP, Neut, FuncS, ELISA, FC, ICC IgG1 - kappa
TAB-H65 Anti-Human MUC1 Recombinant Antibody (Sontuzumab) WB, ELISA, FC, IP, FuncS, IF, Neut IgG1
TAB-037-F(E) Anti-Human MUC1 Recombinant Antibody Fab Fragment (Clivatuzumab Tetraxetan) Neut, ELISA, IF, IP, FuncS, FC, IHC Fab - G1 - kappa
TAB-H77 Human Anti-MUC1 Recombinant Antibody (TAB-H77) FuncS, Inhib IgG1, κ
TAB-026ML Anti-Human MUC1 Recombinant Antibody (Gatipotuzumab) ELISA, IHC, FC, IP, IF, FuncS IgG1, κ

Immunotoxin

CAT Product Name Application Type
AGTO-L036E anti-MUC1 immunotoxin C242 (Fab)-PE Cytotoxicity assay, Functional assay
AGTO-L064E anti-MUC1 immunotoxin H23 (scFv)-PE Cytotoxicity assay, Functional assay

Human Antibody

CAT Product Name Application Type
TAB-431MZ Anti-Human MUC1 Recombinant Antibody (PH1) ELISA, WB, FC, IHC, SPR Human antibody
TAB-432MZ Human Anti-MUC1 Recombinant Antibody (TAB-432MZ) ELISA, FC, FACS, DB, SPR Human IgG
TAB-433MZ Human Anti-MUC1 Recombinant Antibody (TAB-433MZ) ELISA, FC, FACS, DB, SPR Human IgG
TAB-434MZ Human Anti-MUC1 Recombinant Antibody (TAB-434MZ) ELISA, FC, FACS, DB, SPR Human IgG
TAB-431MZ-F(E) Anti-Human MUC1 Recombinant Antibody Fab Fragment (PH1) ELISA, WB, FC, IHC Human antibody

Fab Glycosylation

CAT Product Name Application Type
Gly-012LC Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) ELISA, FC, IHC Humanized antibody
Gly-120LC Recombinant Anti-Human MUC1 Antibody (Fab glycosylation) ELISA Mouse antibody

Sialylated IgG Glycan

CAT Product Name Application Type
Gly-012LC-1 Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) ELISA, FC, IHC Humanized antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-109LC Recombinant Anti-Human MUC1 Antibody (Fc glycosylation) ELISA Human antibody

Deglycosylated Antibody (Non-glycosylated IgGs)

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0379MZ Chicken Anti-MUC1 Polyclonal IgY IHC, WB Chicken antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2320 Hi-Affi™ Recombinant Rabbit Anti-MUC1 Monoclonal Antibody (DS2320AB) IHC-P, IHC-Fr IgG

Recombinant Antibody

CAT Product Name Application Type
HPAB-0872LY Mouse Anti-MUC1 Recombinant Antibody (HPAB-0872LY) ELISA, WB, FC Mouse IgG1
HPAB-0873LY Human Anti-MUC1 Recombinant Antibody (HPAB-0873LY) ELISA, WB, FC Humanized IgG1
HPAB-0874LY Mouse Anti-MUC1 Recombinant Antibody (HPAB-0874LY) ELISA, WB, FC Mouse IgG1
HPAB-0875LY Human Anti-MUC1 Recombinant Antibody (HPAB-0875LY) ELISA, WB, FC Humanized IgG1
HPAB-0207-YJ Human Anti-MUC1 Recombinant Antibody (clone Clivatuzumab (hPAM4)) ELISA, RIA, IHC, Immunoperoxidase Staining, Inhib, FuncS Humanized IgG, κ

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H56 Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Pemtumomab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC ADCC enhanced antibody
AFC-TAB-H65 Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Sontuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF ADCC enhanced antibody
AFC-TAB-026ML Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Gatipotuzumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody
AFC-TAB-166 Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Cantuzumab), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody
AFC-TAB-H77 Afuco™ Human Anti-MUC1 Recombinant Antibody, ADCC Enhanced (AFC-TAB-H77) ELISA, FC, IP, FuncS, IF IgG1, κ

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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