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    CD19 & CD47

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    Anti-CD19 & CD47 Products

    • Anti-CD19 (clone huB4)-SMCC-DM1 ADC (ADC-157LZY)
      • Target: CD19
      • Linker: SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-CD19 (clone B496)-SPP-DM1 ADC (ADC-181LZY)
      • Target: CD19
      • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-CD19 (clone B496)-MCC-DM1 ADC (ADC-182LZY)
      • Target: CD19
      • Linker: MCC (Maleimidomethyl cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-CD19 (huB4)-SPDB-DM4 ADC (ADC-020LCT)
      • Target: CD19
      • Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
      • Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes.
    Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
    CD19 & CD47
    Related Diseases
    Primary Immunodeficiency Primary Immunodeficiency
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