CD19 & CD47

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Anti-CD19 & CD47 Products

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    • Target: CD19
    • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Target: CD19
    • Linker: MCC (Maleimidomethyl cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Target: CD19
    • Linker: SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Target: CD19
    • Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
    • Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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Background

CD19: Encodes a B-cell surface receptor involved in antigen signaling. It amplifies B-cell receptor signals to regulate proliferation and differentiation. The protein is essential for humoral immunity. Mutations cause immunodeficiency.
CD19 & CD47
CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Hereditary Spherocytosis and Neonatal Meningitis. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include thrombospondin receptor activity.
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