Anti-CD19 (hBU12)-Mc-MMAF ADC (SGN-19A) (CAT#: ADC-L034)

• Antibody Overview
• Humanized IgG1k antibody hBU12 (Anti-CD19)

• Clone
• hBU12

• Antibody Conjugation
• Humanized

• Linker
• Mc (maleimidocaproyl)

• Linker Class/Description
• Class: Noncleavable linkers
  Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

• Drug
• MMAF (Monomethyl auristatin F)

• Drug Class/Description
• Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

• Alternative Names
• B4; CVID3

• Gene ID
• 930

• UniProt ID
• P15391

• ADC-150CL
• Anti-CD19 (clone hBU12)-vcPAB-MMAE ADC

• ADC-017LCT
• Anti-CD19 (hBU12)-mcMMAF ADC

• ADC-019LCT
• Anti-CD19 (hBU12)-Mc-MMAE ADC

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