Anti-CD19 (clone hBU12)-vcPAB-MMAE ADC (CAT#: ADC-150CL)

• Antibody Overview
• Anti-Human CD19 Antibody hBU12

• Clone
• hBU12

• Antibody Conjugation
• with C-terminal LPETG sortase tag and additional 6x-His and strepII affinity purification tags

• Linker
• VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)

• Linker Class/Description
• Class: Enzymatically cleavable linkers-Peptide linkers
  Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• MMAE (Monomethyl auristatin E)

• Drug Class/Description
• Class: Auristatin
  Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]

• Alternative Names
• CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4;

• Gene ID
• 930

• UniProt ID
• P15391

• ADC-017LCT
• Anti-CD19 (hBU12)-mcMMAF ADC

• ADC-019LCT
• Anti-CD19 (hBU12)-Mc-MMAE ADC

• ADC-L034
• Anti-CD19 (hBU12)-Mc-MMAF ADC (SGN-19A)

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