anti-CD19 immunotoxin HD37 (scFv)-Sap (CAT#: AGTO-L047S)

This immunotoxin was achieved by conjugating/fusing the Anti-CD19 scFv to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cancer cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of Head and neck squamous cell cancer or bladder cancer.


Specific Inquiry
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  • Gene Expression
  • Datasheet
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  • COA
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • HD37
  • Molecule Class
  • scFv-Sap
  • Toxin Description
  • Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Head and neck squamous cell cancer or bladder cancer

Target

  • Alternative Names
  • CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4; Head and neck squamous cell cancer; bladder cancer; saporin; saporin-6; saporin-S6; SAP

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Mouse Antibody

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TAB-174 Mouse Anti-CD19 Recombinant Antibody (clone Taplitumomab) ELISA, IP, FC, FuncS, Neut, IF, ICC Mouse IgG1, κ
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TAB-1622CL Mouse Anti-CD19 Recombinant Antibody (TAB-1622CL) ELISA, FC, Apop, ADCC, FuncS Mouse IgG
TAB-1623CL Mouse Anti-CD19 Recombinant Antibody (TAB-1623CL) ELISA, FC Mouse IgG
TAB-1624CL Anti-Human CD19 Recombinant Antibody (381) FC, Inhib, ELISA

Humanized Antibody

CAT Product Name Application Type
TAB-891 Humanized Anti-CD19 Recombinant Antibody (clone Denintuzumab) ELISA, FC, IP, FuncS, IF, Neut, ICC Humanized IgG1, κ
TAB-1612CL-S(P) Human Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1612CL-S(P)) Depletion, FuncS Humanized scFv
TAB-1612CL-F(E) Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1612CL-F(E)) Depletion, FuncS Humanized Fab
TAB-1625CL-F(E) Anti-Human CD19 Recombinant Antibody Fab Fragment (396) Depletion, ELISA Humanized antibody
TAB-431CQ Anti-Human CD19 Recombinant Antibody ELISA, IHC, FC, IP, IF, FuncS IgG1, κ

Immunotoxin

CAT Product Name Application Type
AGTO-G076E Anti-CD19 immunotoxin HD37 (IgG)-PE Cytotoxicity assay, Function study
AGTO-L047E anti-CD19 immunotoxin HD37 (scFv)-PE Cytotoxicity assay, Functional assay
AGTO-L047D anti-CD19 immunotoxin HD37 (scFv)-DT Cytotoxicity assay, Functional assay
AGTO-L047R anti-CD19 immunotoxin HD37 (scFv)-RTA Cytotoxicity assay, Functional assay
AGTO-L047P anti-CD19 immunotoxin HD37 (scFv)-PAP Cytotoxicity assay, Functional assay

Low- or Non-fucosylated Oligosaccharide

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0100MZ Chicken Anti-CD19 Polyclonal IgY WB Chicken antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-286CQ Mouse Anti-CD19 Recombinant Antibody (clone SJ25-C1) Neut, FC, IHC, IHC-Fr, IP Mouse IgG1
NEUT-287CQ Mouse Anti-CD19 Recombinant Antibody (clone HIB19) FC, CyTOF, IHC, Block Mouse IgG1, κ

Blocking Antibody

CAT Product Name Application Type
NEUT-288CQ Rat Anti-CD19 Recombinant Antibody (clone 1D3) Depletion, Block, FC Rat IgG2a

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0538 Hi-Affi™ Rabbit Anti-CD19 Recombinant Antibody (clone DS538AB) IHC-P Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-174 Afuco™ Anti-CD19 ADCC Recombinant Antibody (Taplitumomab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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