This immunotoxin was achieved by conjugating/fusing the Anti-CD19 scFv to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cancer cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of Head and neck squamous cell cancer or bladder cancer.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
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TAB-174 | Mouse Anti-CD19 Recombinant Antibody (clone Taplitumomab) | ELISA, IP, FC, FuncS, Neut, IF, ICC | Mouse IgG1, κ |
TAB-1611CL | Mouse Anti-CD19 Recombinant Antibody (TAB-1611CL) | Depletion, FuncS | Mouse IgG2a, κ |
TAB-1611CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1611CL-S(P)) | Depletion, FuncS | Mouse scFv |
TAB-1620CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (HD37) | FuncS | |
TAB-1622CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1622CL-S(P)) | ELISA, FC, Apop, ADCC, FuncS | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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