Anti-CD19 (clone huB4)-SMCC-DM1 ADC (CAT#: ADC-157LZY)

• Antibody Overview
• Humanized Anti-CD19 IgG1,huB4

• Clone
• huB4

• Antibody Isotype
• IgG1

• Linker
• SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).

• Linker Class/Description
• Class: Noncleavable linker
  Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation

• Drug
• DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)

• Drug Class/Description
• Class: Maytansinoid
  Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
  macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

• Introduction
• Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]

• Alternative Names
• CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4;

• Gene ID
• 930

• UniProt ID
• P15391

• ADC-020LCT
• Anti-CD19 (huB4)-SPDB-DM4 ADC

• ADC-045LZY
• Anti-CD19 (clone huB4)-mc-MMAF ADC

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