Afuco™ Anti-Human CD19 ADCC Recombinant Antibody (MDX-1342), ADCC Enhanced
CAT#: AFC-104CL
Anti-CD19 ADCC Enhanced Antibody (MDX-1342) is an ADCC enhanced antibody produced by our Afuco™ platform. MDX-1342 is a fully human monoclonal antibody (HuMAb) with enhanced antibody-dependent cellular cytotoxicity (ADCC) effector function, targeting CD19-membrane receptor which is highly expressed on malignant chronic lymphocytic leukemia (CLL) cells.
Gene Expression
Normal Tissue
Figure 1 Colon
Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_7_3.jpg
Normal Tissue
Figure 2 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_5_6.jpg
Normal Tissue
Figure 3 Appendix
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_2_2.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Daudi, REH, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177455-CD19
❮
❯
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Chronic Lymphocytic Leukemia; Rheumatoid Arthritis
Product Property
- Purity
- >90% assessed by SDS-PAGE
- Storage
- Can be stored at 4°C. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.
Target
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Superior ADCC Activity
The ADCC enhancement in this antibody is remarkable. It has significantly improved the effectiveness of our in vitro cytotoxicity assays against CD19+ B cells.
High Specificity
The specificity of this antibody for CD19 is impressive. It has minimal off-target effects, which is crucial for our studies of B cell signaling pathways.
Q&As
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What benefits does the ADCC enhancement of this antibody provide for research purposes?
A: The antibody's capacity to induce cell lysis through immune effector cells is enhanced by the ADCC, making it possible to more successfully investigate immune-cell-mediated cytotoxicity against B cells in a variety of experiments.
-
What are the benefits of using a recombinant antibody like the Afuco™ Anti-Human CD19 ADCC?
A: High batch-to-batch uniformity, less lot fluctuation, and no chance of animal infections are all benefits of recombinant antibodies. This guarantees excellent specificity and repeatable outcomes in experiments.
View the frequently asked questions answered by Creative Biolabs Support.
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Related Diseases
Primary Immunodeficiency
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| TAB-1616CL-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1616CL-S(P)) | ELISA, WB | Human scFv |
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| CAT | Product Name | Application | Type |
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| TAB-1622CL | Mouse Anti-CD19 Recombinant Antibody (TAB-1622CL) | ELISA, FC, Apop, ADCC, FuncS | Mouse IgG |
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| TAB-1613CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1613CL-S(P)) | Depletion, FuncS | Mouse scFv |
| TAB-1614CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1614CL-S(P)) | FuncS | Mouse scFv |
| TAB-1621CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (cHD37) | FuncS | Chimeric antibody (mouse/human) |
| TAB-1613CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1613CL-F(E)) | Depletion, FuncS | Chimeric (mouse/human) Fab |
| TAB-1614CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1614CL-F(E)) | FuncS | Chimeric (mouse/human) Fab |
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| Gly-061LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Low fucosylated) | ELISA, FC | Chimeric antibody (mouse/human) |
| Gly-105LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation) | ELISA | Mouse antibody |
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| CAT | Product Name | Application | Type |
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| Gly-061LC-1 | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Low fucosylated) | ELISA, FC | Chimeric antibody (mouse/human) |
| Gly-141LC-1 | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
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| BRD-0100MZ | Chicken Anti-CD19 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
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| NEUT-286CQ | Mouse Anti-CD19 Recombinant Antibody (clone SJ25-C1) | Neut, FC, IHC, IHC-Fr, IP | Mouse IgG1 |
| NEUT-287CQ | Mouse Anti-CD19 Recombinant Antibody (clone HIB19) | FC, CyTOF, IHC, Block | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-288CQ | Rat Anti-CD19 Recombinant Antibody (clone 1D3) | Depletion, Block, FC | Rat IgG2a |
| CAT | Product Name | Application | Type |
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| HPAB-0418LY | Human Anti-CD19 Recombinant Antibody (HPAB-0418LY) | Cyt, BLI, FC, FuncS, ELISA, WB, RIA | Human IgG1 |
| HPAB-0419LY | Human Anti-CD19 Recombinant Antibody (HPAB-0419LY) | ELISA, WB, FC, RIA | Human IgG1 |
| HPAB-0420LY | Human Anti-CD19 Recombinant Antibody (HPAB-0420LY) | ELISA, WB, FC, RIA | Human IgG1 |
| HPAB-0421LY | Human Anti-CD19 Recombinant Antibody (HPAB-0421LY) | ELISA, WB, FC, RIA | Human IgG1 |
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| HPAB-0696LY-F(E) | Mouse Anti-CD19 Recombinant Antibody (clone PGC3D6H10); Fab Fragment | ELISA, WB, FC, IF | Mouse Fab |
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| HPAB-0362-FY-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0362-FY-F(E)) | FC | Mouse Fab |
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| HPAB-616-FY-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-616-FY-S(P)) | ELISA | Human scFv |
| HPAB-0707-FY-F(E) | Mouse Anti-CD19 Recombinant Antibody (clone AB006); scFv Fragment | ELISA | Mouse scFv |
| HPAB-3158LY-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-3158LY-S(P)) | ELISA | Mouse scfv |
| HPAB-3159LY-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-3159LY-S(P)) | ELISA | Mouse scfv |
| HPAB-3160LY-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-3160LY-S(P)) | ELISA | Mouse scfv |
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