Afuco™ Anti-Human CD19 ADCC Recombinant Antibody (MDX-1342), ADCC Enhanced (CAT#: AFC-104CL)
Anti-CD19 ADCC Enhanced Antibody (MDX-1342) is an ADCC enhanced antibody produced by our Afuco™ platform. MDX-1342 is a fully human monoclonal antibody (HuMAb) with enhanced antibody-dependent cellular cytotoxicity (ADCC) effector function, targeting CD19-membrane receptor which is highly expressed on malignant chronic lymphocytic leukemia (CLL) cells.
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We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Normal Tissue
RNA Expression
Figure 1 Colon
(Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_7_3.jpg
(Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_7_3.jpg
Figure 2 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_5_6.jpg
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_5_6.jpg
Figure 3 Appendix
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_2_2.jpg
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_2_2.jpg
Figure 4 Lymph node
(Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_9_8.jpg
(Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_9_8.jpg
Figure 5 RNA cell line category: Cell line enhanced (Daudi, REH, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177455-CD19
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177455-CD19
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Chronic Lymphocytic Leukemia; Rheumatoid Arthritis
Product Property
- Purity
- >90% assessed by SDS-PAGE
- Storage
- Can be stored at 4°C. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.
Target
- Alternative Names
- CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4
- Gene ID
- 930
- UniProt ID
- P15391
Related Resources
Primary Immunodeficiency
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1087z | Mouse Anti-CD19 Recombinant Antibody (clone 32B9) | WB, FC, ICC, IF, FuncS | Mouse IgG1 |
| HPAB-0264-CN | Human Anti-CD19 Recombinant Antibody (HPAB-0264-CN) | ELISA, FC | Humanized IgG1, κ |
| HPAB-0265-CN | Human Anti-CD19 Recombinant Antibody (HPAB-0265-CN) | ELISA, FC | Humanized IgG1, κ |
| HPAB-0266-CN | Human Anti-CD19 Recombinant Antibody (HPAB-0266-CN) | ELISA, FC | Humanized IgG |
| HPAB-0267-CN | Human Anti-CD19 Recombinant Antibody (HPAB-0267-CN) | ELISA, FC | Humanized IgG |
Customer Reviews and Q&As
Customer Review
Q&As
Superior ADCC Activity
The ADCC enhancement in this antibody is remarkable. It has significantly improved the effectiveness of our in vitro cytotoxicity assays against CD19+ B cells.
High Specificity
The specificity of this antibody for CD19 is impressive. It has minimal off-target effects, which is crucial for our studies of B cell signaling pathways.
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For Research Use Only. Not For Clinical Use.
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