Anti-CD19 immunotoxin HD37 (IgG)-DT (CAT#: AGTO-G076D)
This immunotoxin was achieved by conjugating/fusing the Anti-CD19 monoclonal antibody to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and the toxin enters cells by receptor-mediated endocytosis. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death. It was designed for treatment of lymphoma.
Specific Inquiry
SDS-PAGE
Figure 1 Anti-CD19 immunotoxin HD37 (IgG)-DT in SDS-PAGE
Validation of purified immunotoxin (IT) by SDS-PAGE.
"HC-DT" represents heavy chain of the IgG1 fused with DT389.
"LC" represents the light chain of IgG1.
"M" represents protein standards in kilodalton (kDa).
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- HD37
- Molecule Class
- L kappa; IgG-DT
- Toxin Description
- Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- lymphoma
Target
- Alternative Names
- CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4; Diphtheria toxin; Diphtheria-toxin; DT; DT388; DT389; DT390; DAB454
- Gene ID
- 930
- UniProt ID
- P15391
Related Resources
Primary Immunodeficiency
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone HD37"
See other products for "CD19"
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H17 | Anti-Human CD19 Recombinant Antibody (Denintuzumab Mafodotin) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
| TAB-891 | Humanized Anti-CD19 Recombinant Antibody (clone Denintuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | Humanized IgG1, κ |
| TAB-1612CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1612CL-F(E)) | Depletion, FuncS | Humanized Fab |
| TAB-1625CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (396) | Depletion, ELISA | Humanized antibody |
| TAB-431CQ | Anti-Human CD19 Recombinant Antibody | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G076E | Anti-CD19 immunotoxin HD37 (IgG)-PE | Cytotoxicity assay, Function study | |
| AGTO-G076R | Anti-CD19 immunotoxin HD37 (IgG)-RTA | Cytotoxicity assay, Function study | |
| AGTO-G076S | Anti-CD19 immunotoxin HD37 (IgG)-Sap | Cytotoxicity assay, Function study | |
| AGTO-G076P | Anti-CD19 immunotoxin HD37 (IgG)-PAP | Cytotoxicity assay, Function study | |
| AGTO-L047E | anti-CD19 immunotoxin HD37 (scFv)-PE | Cytotoxicity assay, Functional assay |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1613CL | Human Anti-CD19 Recombinant Antibody (TAB-1613CL) | Cyt, FC, FuncS, Inhib | Chimeric (mouse/human) IgG1 |
| TAB-1621CL | Anti-Human CD19 Recombinant Antibody (cHD37) | ADCC, FuncS | Chimeric antibody (mouse/human) |
| TAB-1613CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1613CL-S(P)) | Depletion, FuncS | Mouse scFv |
| TAB-1614CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1614CL-S(P)) | FuncS | Mouse scFv |
| TAB-1621CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (cHD37) | FuncS | Chimeric antibody (mouse/human) |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1616CL-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1616CL-S(P)) | ELISA, WB | Human scFv |
| TAB-1617CL-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1617CL-S(P)) | ELISA, WB | Human scFv |
| TAB-1618CL-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1618CL-S(P)) | ELISA, WB | Human scFv |
| TAB-1626CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (HB12a) | Depletion | Fully human antibody |
| TAB-1627CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (HB12b) | Depletion | Fully human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1611CL-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1611CL-F(E)) | Depletion, FuncS | Mouse Fab |
| TAB-1620CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (HD37) | FuncS | |
| TAB-1622CL-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1622CL-F(E)) | ELISA, FC, Apop, ADCC, FuncS | Mouse Fab |
| TAB-1623CL-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1623CL-F(E)) | ELISA, FC | Mouse Fab |
| TAB-1624CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (381) | FC, Inhib, ELISA |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-061LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Low fucosylated) | ELISA, FC | Chimeric antibody (mouse/human) |
| Gly-105LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation) | ELISA | Mouse antibody |
| Gly-141LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Low- or Non-fucosylated Oligosaccharide
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-061LC-1 | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Low fucosylated) | ELISA, FC | Chimeric antibody (mouse/human) |
| Gly-141LC-1 | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0100MZ | Chicken Anti-CD19 Polyclonal IgY | WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-286CQ | Mouse Anti-CD19 Recombinant Antibody (clone SJ25-C1) | Neut, FC, IHC, IHC-Fr, IP | Mouse IgG1 |
| NEUT-287CQ | Mouse Anti-CD19 Recombinant Antibody (clone HIB19) | FC, CyTOF, IHC, Block | Mouse IgG1, κ |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-288CQ | Rat Anti-CD19 Recombinant Antibody (clone 1D3) | Depletion, Block, FC | Rat IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0538 | Hi-Affi™ Rabbit Anti-CD19 Recombinant Antibody (clone DS538AB) | IHC-P | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0264-CN | Human Anti-CD19 Recombinant Antibody (HPAB-0264-CN) | ELISA, FC | Humanized IgG1, κ |
| HPAB-0265-CN | Human Anti-CD19 Recombinant Antibody (HPAB-0265-CN) | ELISA, FC | Humanized IgG1, κ |
| HPAB-0266-CN | Human Anti-CD19 Recombinant Antibody (HPAB-0266-CN) | ELISA, FC | Humanized IgG |
| HPAB-0267-CN | Human Anti-CD19 Recombinant Antibody (HPAB-0267-CN) | ELISA, FC | Humanized IgG |
| HPAB-0268-CN | Human Anti-CD19 Recombinant Antibody (HPAB-0268-CN) | ELISA, FC | Human IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0023LY-F(E) | Humanized Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0023LY-F(E)) | WB | Fab |
| HPAB-0036LY-F(E) | Humanized Anti-CD19 Antibody Fab Fragment (Hbu12) | WB | Fab |
| HPAB-0418LY-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0418LY-F(E)) | ELISA, WB, FC, RIA | Human Fab |
| HPAB-0419LY-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0419LY-F(E)) | ELISA, WB, FC, RIA | Human Fab |
| HPAB-0420LY-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0420LY-F(E)) | ELISA, WB, FC, RIA | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-174 | Afuco™ Anti-CD19 ADCC Recombinant Antibody (Taplitumomab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP275-YC-S(P) | Human Anti-CD19 Recombinant Antibody (clone 16C4); scFv Fragment | FC, Inhib, ADCC, FuncS | Human scFv |
| HPAB-AP276-YC-S(P) | Human Anti-CD19 Recombinant Antibody (clone 16C4-aFuc); scFv Fragment | FC, Inhib, ADCC, FuncS | Human scFv |
| HPAB-0989WJ-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0989WJ-S(P)) | ELISA, FC | Human scFv |
| FAMAB-0071WJ-S(P) | Mouse Anti-CD19 Recombinant Antibody (clone 25C1); scFv Fragment | WB, FC | Human scFv |
| FAMAB-0072WJ-S(P) | Mouse Anti-CD19 Recombinant Antibody (clone BLY3); scFv Fragment | WB, FC | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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