anti-CD19 immunotoxin HD37 (scFv)-DT (CAT#: AGTO-L047D)

This immunotoxin was achieved by conjugating/fusing the Anti-CD19 scFv to Diphtheriatoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cancer cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of Head and neck squamous cell cancer or bladder cancer.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • HD37
  • Molecule Class
  • scFv-DT
  • Toxin Description
  • Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Head and neck squamous cell cancer or bladder cancer

Target

  • Alternative Names
  • CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4; Head and neck squamous cell cancer; bladder cancer; Diphtheria toxin; Diphtheria-toxin; DT; DT388; DT389; DT390; DAB389

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone HD37"

See other products for "CD19"

Humanized Antibody

CAT Product Name Application Type
TAB-H17 Anti-Human CD19 Recombinant Antibody (Denintuzumab Mafodotin) IF, IP, Neut, FuncS, ELISA, FC, WB IgG1 - kappa
TAB-891 Humanized Anti-CD19 Recombinant Antibody (clone Denintuzumab) ELISA, FC, IP, FuncS, IF, Neut, ICC Humanized IgG1, κ
TAB-1612CL Human Anti-CD19 Recombinant Antibody (TAB-1612CL) Depletion, FuncS Humanized IgG1
TAB-1625CL Anti-Human CD19 Recombinant Antibody (396) Depletion, ELISA Humanized antibody
TAB-431CQ Anti-Human CD19 Recombinant Antibody ELISA, IHC, FC, IP, IF, FuncS IgG1, κ

Immunotoxin

CAT Product Name Application Type
AGTO-G076E Anti-CD19 immunotoxin HD37 (IgG)-PE Cytotoxicity assay, Function study
AGTO-G076D Anti-CD19 immunotoxin HD37 (IgG)-DT Cytotoxicity assay, Function study
AGTO-G076R Anti-CD19 immunotoxin HD37 (IgG)-RTA Cytotoxicity assay, Function study
AGTO-G076S Anti-CD19 immunotoxin HD37 (IgG)-Sap Cytotoxicity assay, Function study
AGTO-G076P Anti-CD19 immunotoxin HD37 (IgG)-PAP Cytotoxicity assay, Function study

Chimeric Antibody

CAT Product Name Application Type
TAB-1613CL Human Anti-CD19 Recombinant Antibody (TAB-1613CL) Cyt, FC, FuncS, Inhib Chimeric (mouse/human) IgG1
TAB-1614CL Human Anti-CD19 Recombinant Antibody (TAB-1614CL) FuncS Chimeric (mouse/human) IgG
TAB-1621CL Anti-Human CD19 Recombinant Antibody (cHD37) ADCC, FuncS Chimeric antibody (mouse/human)
TAB-1613CL-F(E) Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1613CL-F(E)) Depletion, FuncS Chimeric (mouse/human) Fab
TAB-1621CL-F(E) Anti-Human CD19 Recombinant Antibody Fab Fragment (cHD37) FuncS Chimeric antibody (mouse/human)

Low- or Non-fucosylated Oligosaccharide

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0100MZ Chicken Anti-CD19 Polyclonal IgY WB Chicken antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-286CQ Mouse Anti-CD19 Recombinant Antibody (clone SJ25-C1) Neut, FC, IHC, IHC-Fr, IP Mouse IgG1
NEUT-287CQ Mouse Anti-CD19 Recombinant Antibody (clone HIB19) FC, CyTOF, IHC, Block Mouse IgG1, κ

Blocking Antibody

CAT Product Name Application Type
NEUT-288CQ Rat Anti-CD19 Recombinant Antibody (clone 1D3) Depletion, Block, FC Rat IgG2a

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0538 Hi-Affi™ Rabbit Anti-CD19 Recombinant Antibody (clone DS538AB) IHC-P Rabbit IgG

Recombinant Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-174 Afuco™ Anti-CD19 ADCC Recombinant Antibody (Taplitumomab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for AGTO-L047D. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare