Anti-CD19 immunotoxin HD37 (IgG)-Sap (CAT#: AGTO-G076S)

This immunotoxin was achieved by conjugating/fusing the Anti-CD19 monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of lymphoma.

Specific Inquiry
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression


  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • HD37
  • Molecule Class
  • L kappa; IgG-Sap
  • Toxin Description
  • Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • lymphoma


  • Alternative Names
  • CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4; saporin; saporin-6; saporin-S71; SAP

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.


Download resources about recombinant antibody development and antibody engineering to boost your research.

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Humanized Antibody

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CAT Product Name Application Type
AGTO-G076E Anti-CD19 immunotoxin HD37 (IgG)-PE Cytotoxicity assay, Function study
AGTO-G076D Anti-CD19 immunotoxin HD37 (IgG)-DT Cytotoxicity assay, Function study
AGTO-G076R Anti-CD19 immunotoxin HD37 (IgG)-RTA Cytotoxicity assay, Function study
AGTO-G076P Anti-CD19 immunotoxin HD37 (IgG)-PAP Cytotoxicity assay, Function study
AGTO-L047E anti-CD19 immunotoxin HD37 (scFv)-PE Cytotoxicity assay, Functional assay

Chimeric Antibody

Low- or Non-fucosylated Oligosaccharide

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0100MZ Chicken Anti-CD19 Polyclonal IgY WB Chicken antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-286CQ Mouse Anti-CD19 Recombinant Antibody (clone SJ25-C1) Neut, FC, IHC, IHC-Fr, IP Mouse IgG1
NEUT-287CQ Mouse Anti-CD19 Recombinant Antibody (clone HIB19) FC, CyTOF, IHC, Block Mouse IgG1, κ

Blocking Antibody

CAT Product Name Application Type
NEUT-288CQ Rat Anti-CD19 Recombinant Antibody (clone 1D3) Depletion, Block, FC Rat IgG2a

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0538 Hi-Affi™ Rabbit Anti-CD19 Recombinant Antibody (clone DS538AB) IHC-P Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-174 Afuco™ Anti-CD19 ADCC Recombinant Antibody (Taplitumomab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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