Anti-CD19 (clone MDX1435)-vc-duocarmycin ADC (CAT#: ADC-163LZY)

• Antibody Overview
• MDX1435 (Fully Human Anti-CD19 mAb)

• Clone
• MDX1435

• Linker
• VC (valine-citrulline)

• Linker Class/Description
• Class: Enzymatically cleavable linker-Peptide linker
  Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• duocarmycin

• Drug Class/Description
• Class: Duocarmycin
  Description: Duocarmycins belong to the minor-groove-binding DNA-alkylating agents (DNA MGBA). The natural duocarmycins are isolated from the culture broth of Streptmyces sp and a series of derivatives has also been synthesized

• Introduction
• Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]

• Alternative Names
• CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4;

• Gene ID
• 930

• UniProt ID
• P15391

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