Anti-CD86 (clone Hu3D1) Recombinant Antibody Coupled Liposome (VS-1024-FY6) (CAT#: VS-1024-FY6)
Anti-CD86 antibody liposomes target dendritic cells (DCs) expressing CD86, providing a co-stimulatory signal for the immune response. They enhance the antigen-presenting capacity of DCs, promoting T cell activation and proliferation. The mechanism of action of these liposomes may include the enhancement of cytokine production by DCs, thereby activating downstream immune responses. Ultimately, this strategy may improve anti-tumor immunity in cancer immunotherapy.
More Infomation
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HDLM-2
(Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26802/1962_A12_6_selected.jpg
(Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26802/1962_A12_6_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_B_8_5.jpg
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_B_8_5.jpg
Figure 3 Lung
(Macrophages Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_A_1_4.jpg
(Macrophages Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_A_1_4.jpg
Figure 4 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_A_8_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_A_8_3.jpg
Figure 5 Lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_A_9_8.jpg
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_A_9_8.jpg
Figure 6 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000114013-CD86
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000114013-CD86
Specifications
- Potential Clinical Applications
- Specific targeting of dendritic cells
Product Composition
- Clone
- Hu3D1
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- The anti-B7-2 antibody is a humanized monoclonal antibody that specifically targets the B7-2 molecule found on antigen-presenting cells (APCs). This antibody has potential applications in treating autoimmune diseases, preventing transplant rejection, addressing inflammatory disorders, and managing infectious diseases.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CD86
- Introduction
- CD86 (CD86 Molecule) is a Protein Coding gene. Diseases associated with CD86 include Gallbladder Squamous Cell Carcinoma and Myocarditis. Among its related pathways are Cytokine Signaling in Immune system and Th2 Differentiation Pathway. Gene Ontology (GO) annotations related to this gene include receptor binding and coreceptor activity. An important paralog of this gene is CD80.
- Alternative Names
- CD86 Molecule; CD86 Antigen (CD28 Antigen Ligand 2, B7-2 Antigen); CTLA-4 Counter-Receptor B7.2; CD28LG2; FUN-1; BU63; B70; B-Lymphocyte Activation Antigen B7-2
- Full Name
- CD86 Molecule
- Gene ID
- 942
- UniProt ID
- P42081
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation. (P42081-CD86_HUMAN)
Glycosylation at Asn135, Asn33, Asn146, Asn47, Asn154, Asn177, Asn192, and Asn213 (NX_P42081 [NX_P42081-1])
Modification sites at PhosphoSitePlus (P42081)
Glycosylation from GlyGen (P42081) 8 sites
- Protein Refseq
- NP_001193853.2; NP_001193854.2; NP_008820.4; NP_787058.5; NP_795711.2
- Function
- May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation.
Related Resources
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Allograft Rejection
Autoimmune Thyroid Disease
Graft-versus-Host Disease
Maturity Onset Diabetes of the Young
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L002G | anti-CD86 immunotoxin 1G10 (IgG)-Gel | Cytotoxicity assay, Functional assay | |
| AGTO-L002S | anti-CD86 immunotoxin 1G10 (IgG)-Sap | Cytotoxicity assay, Functional assay | |
| AGTO-L002O | anti-CD86 immunotoxin 1G10 (IgG)-Bouganin | Cytotoxicity assay, Functional assay |
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