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CTLA4 & CD40

Anti-CTLA4 & CD40 Products
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: WB, FuncS, IF, Neut, ELISA, FC, IP
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG2
- Application: WB, IF, IP, Neut, FuncS, ELISA, FC
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1
- Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
- Human Anti-CD40 Recombinant Antibody (TAB-126CL) (TAB-126CL)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG
- Application: Block, Cyt, FuncS, Inhib
- AbPlus™ Anti-CTLA4 Magnetic Beads (14D3) (VS-0424-XY73)
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- Target: CTLA4
- Target Species: Human, Monkey
- Application: IP, Protein Purification
- Rabbit Anti-CTLA4 Recombinant Antibody (VS-0723-WK194) (VS-0723-WK194)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, FC
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA
- Mouse Anti-CTLA4 Recombinant Antibody (VS3-FY2678) (VS3-FY2678)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB
- Mouse Anti-CTLA4 Agonistic Antibody (VS-0724-XY22) (VS-0724-XY22)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB, Agonistic assays
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, IF
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, IF
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, IF
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- Species Reactivity: Human
- Type: Mouse IgG2a
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: FC, FuncS
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: IgG1
- Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: ELISA, FC, IP, FuncS, IF, Neut, IHC
- Human Anti-CTLA4 Recombinant Antibody (clone CBC01) (VS-0824-YJ3)
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- Species Reactivity: Human
- Type: Human IgG1 kappa
- Application: IA
- Mouse Anti-CTLA4 Recombinant Antibody (clone 10A8) (VS-0824-YJ26)
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- Species Reactivity: Human
- Type: Mouse IgG2a kappa
- Application: ELISA, Block
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Rabbit Anti-CTLA4 Recombinant Antibody (VS-0723-WK193) (VS-0723-WK193)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, FC
- Mouse Anti-CTLA4 Antibody, mRNA (AGTO-G015E-mRNA)
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- Species Reactivity: Human
- Mouse Anti-CTLA4 Antibody (clone HK44), mRNA (HPAB-0478LY-mRNA)
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- Species Reactivity: Human
- Human Anti-CTLA4 Antibody, mRNA (HPAB-0306-FY-mRNA) (HPAB-0306-FY-mRNA)
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- Species Reactivity: Human
- Hamster Anti-CTLA4 Antibody (clone FY-002), mRNA (HPAB-1097-FY-mRNA)
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- Species Reactivity: Mouse
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, IHC
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC
- Human Anti-CTLA4 Recombinant Antibody (clone 6.1.1) (HPAB-S0013-YC)
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- Species Reactivity: Human
- Type: Human IgG2
- Application: ELISA, Block
- Human Anti-CTLA4 Recombinant Antibody (clone L4P2F5*F10) (FAMAB-1557CQ)
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- Species Reactivity: Bovine, Human, Mouse, Rat
- Type: Human IgG1
- Application: WB, ELISA, IHC
- Human Anti-CTLA4 Antibody (clone L4P2F5*F10), mRNA (FAMAB-1557CQ-mRNA)
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- Species Reactivity: Bovine, Human, Mouse, Rat
- Rat Anti-Cd40 Agonistic Antibody (VS-0724-XY19) (VS-0724-XY19)
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- Species Reactivity: Mouse
- Type: Rat IgG2a
- Application: FC, IP, Agonistic assays, CyTOF®
- Rabbit Anti-Cd40 Agonistic Antibody (VS-0724-XY20) (VS-0724-XY20)
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- Species Reactivity: Mouse
- Type: Rabbit IgG, kappa
- Application: FC, WB, FuncS, Activ, Agonistic assays
- Rat Anti-Cd40 Agonistic Antibody (clone FGK45) (VS-0724-XY21)
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- Species Reactivity: Mouse
- Type: Rat IgG2a, kappa
- Application: FC, WB, FuncS, Activ, Agonistic assays
- AbPlus™ Anti-CD40 Magnetic Beads (VS-0724-YC1328) (VS-0724-YC1328)
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- Target: CD40
- Target Species: Human
- Application: IP, Protein Purification
- Human Anti-CTLA4 Recombinant Antibody (clone 4.8.1) (HPAB-S0011-YC)
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- Species Reactivity: Human
- Type: Human IgG2
- Application: ELISA, Block
- Rabbit Anti-CD40 Recombinant Antibody (VS-0723-WK279) (VS-0723-WK279)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, FC
- Human Anti-CTLA4 Recombinant Antibody (clone 11.2.1) (HPAB-S0012-YC)
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- Species Reactivity: Human
- Type: Human IgG2
- Application: ELISA, FuncS
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
- Mouse Anti-CTLA4 Recombinant Antibody (clone 26) (HPAB-1270WJ)
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- Species Reactivity: Human
- Type: Mouse IgG, κ
- Application: ELISA, FC
- Mouse Anti-CD40 Agonistic Antibody (VS-0724-XY18) (VS-0724-XY18)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: FC, Agonistic assays, CyTOF®, ICC
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- Species Reactivity: Human
- Type: Mouse IgG2a
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Human Anti-CTLA4 Recombinant Antibody (clone h26) (HPAB-1271WJ)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG, κ
- Application: ELISA, FC
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- Type: Mouse IgG1
- Application: ELISA, WB, FC, IHC
- Human Anti-CTLA4 Recombinant Antibody (HPAB-1302WJ) (HPAB-1302WJ)
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, WB, FC
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- Type: Mouse IgG1
- Application: ELISA, WB, FC
- Human Anti-CTLA4 Recombinant Antibody (HPAB-1303WJ) (HPAB-1303WJ)
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, WB, FC
- Rabbit Anti-CD40 Recombinant Antibody (VS-0723-WK255) (VS-0723-WK255)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, FC
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- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: ELISA
- Rabbit Anti-CD40 Recombinant Antibody (VS-0723-WK278) (VS-0723-WK278)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, IF
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, IF
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, IF
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- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, IF
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- Species Reactivity: Human
- Type: Mouse IgG2a
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized VHH
- Application: ELISA, Block
- Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-1302WJ-S(P)) (HPAB-1302WJ-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB, FC
- Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-1303WJ-S(P)) (HPAB-1303WJ-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized VHH
- Application: ELISA, Block
- Mouse Anti-CTLA4 Recombinant Antibody (clone 26); Fab Fragment (HPAB-1270WJ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
- Human Anti-CTLA4 Recombinant Antibody (clone h26); Fab Fragment (HPAB-1271WJ-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC
- Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-1302WJ-F(E)) (HPAB-1302WJ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized VHH
- Application: ELISA, Block
- Mouse Anti-CTLA4 Recombinant Antibody (clone 26); scFv Fragment (HPAB-1270WJ-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
- Human Anti-CTLA4 Recombinant Antibody (clone h26); scFv Fragment (HPAB-1271WJ-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC
- Human Anti-CTLA4 Recombinant Antibody (clone 11.2.1); Fab Fragment (HPAB-S0012-YC-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FuncS
- Human Anti-CTLA4 Recombinant Antibody (clone 4.8.1); Fab Fragment (HPAB-S0011-YC-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Block
- Human Anti-CTLA4 Recombinant Antibody (clone 4.8.1); scFv Fragment (HPAB-S0011-YC-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, Block
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- Species Reactivity: Human, Monkey
- Type: Antibody hexamer
- Application: ELISA, ADCC, CDC
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- Species Reactivity: Human
- Type: Antibody hexamer
- Application: ELISA, Block, FC, IF, Activ, CDC
- Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-1303WJ-F(E)) (HPAB-1303WJ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FC
- Human Anti-CTLA4 Recombinant Antibody (clone 6.1.1); Fab Fragment (HPAB-S0013-YC-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Block
- Human Anti-CTLA4 Recombinant Antibody (clone 6.1.1); scFv Fragment (HPAB-S0013-YC-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, Block
- Human Anti-CTLA4 Recombinant Antibody (clone 11.2.1); scFv Fragment (HPAB-S0012-YC-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FuncS
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- Species Reactivity: Human
- Type: F(ab')2
- Application: FC, EIA, FX, Bios
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC, ELISA
- Anti-CTLA4 immunotoxin (scFv)-PE (AGTO-G015E)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
- Anti-CTLA4 immunotoxin (scFv)-Sap (AGTO-G015S)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
- Anti-CD40 immunotoxin (scFv)-PE (AGTO-G079E)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- Species Reactivity: Human, Rhesus, Cynomolgus, Baboon
- Type: Mouse IgG2a, kappa
- Application: FC
- Anti-CD40 Immunohistochemistry Kit (VS-0525-XY1181)
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- Species Reactivity: Human
- Target: CD40
- Application: IHC
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- Antibody Host: Mouse
- Antibody Reactivity: Human
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- Antibody Host: Human
- Antibody Reactivity: Human
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- Species Reactivity: Mouse
- Type: Armenian Hamster IgG1, kappa
- Application: FC, IP
- Human Anti-CTLA4 (clone JMW-3B3) scFv-Fc Chimera (VS-0325-FY63)
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- Species Reactivity: Human
- Type: Human IgG1, scFv-Fc
- Application: ELISA
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- Species Reactivity: Human
- Target: CTLA4
- Host Animal: Mouse
- Application: ELISA, FC, SPR, Neut, Cell-uptake
- Anti-CTLA4 Immunohistochemistry Kit (VS-0525-XY1763)
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- Species Reactivity: Human
- Target: CTLA4
- Application: IHC
- Anti-Mouse CTLA4 Immunohistochemistry Kit (VS-0525-XY1764)
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- Species Reactivity: Human, Mouse, Rat, Bovine
- Target: CTLA4
- Application: IHC
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- Antibody Host: Rat
- Antibody Reactivity: Mouse
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- Species Reactivity: Mouse, Rat
- Type: Armenian Hamster IgM, kappa
- Application: FC, Block
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- Species Reactivity: Human
- Target: CD40
- Type: Tandem scFv
- Application: ELISA, FC, IP, IF, IHC
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- Species Reactivity: Human
- Target: CD40
- Type: Tandem scFv
- Application: ELISA, FC, IF, IHC, IP
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- Species Reactivity: Human
- Target: CD40
- Type: Tandem scFv
- Application: ELISA, FC, Neut, IHC, IP, IF
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: IF, ICC, ELISA
- Rat Anti-CD40 (clone FGK45) scFv-Fc Chimera (VS-0325-FY89)
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- Species Reactivity: Mouse
- Type: Rat IgG1, scFv-Fc
- Application: FC, WB, Agonist
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FCM
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- Species Reactivity: Human
- Target: CD40
- Host Animal: Mouse
- Application: ELISA, FC, Neut, Cell-uptake
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For Research Use Only. Not For Clinical Use.
Background
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
