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CTLA4 & CD40
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Mouse Anti-CD40 Recombinant Antibody (clone 27G1) (MOB-1269z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: FC, FuncS
Recombinant Mouse Anti-Human CTLA4 Antibody F(ab')2 Fragment, clone ANC152.2/8H5 (DrMAB-986)
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- Species Reactivity: Human
- Type: F(ab')2
- Application: FC, EIA, FX, Bios
Anti-Human CD40 Therapeutic Antibody Fab Fragment (PPAT-071-01) (TAB-0061CL-F(E))
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- Species Reactivity: Cross-react with mouse CD40
- Application: ELISA, FuncS
Anti-Human CD40 Therapeutic Antibody scFv Fragment (PPAT-071-12) (TAB-0072CL-S(P))
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- Species Reactivity: Cross-react with mouse CD40
- Application: ELISA, FuncS
Anti-Human CD40 Therapeutic Antibody scFv Fragment (PPAT-071-01) (TAB-0061CL-S(P))
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- Species Reactivity: Cross-react with mouse CD40
- Application: ELISA, FuncS
Anti-Human CD40 Therapeutic Antibody (PPAT-071-01) (TAB-0061CL)
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- Species Reactivity: Cross-react with mouse CD40
- Application: ELISA, ADCC, CDC, FuncS
10-FnIII scaffold protein anti-Human Cd40l (SFN-L034)
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- Scaffold Name: 10-FnIII
- Target: Cd40l
- Species Reactivity: Human
- Derivation: Phage display
Anti-CTLA4 immunotoxin (scFv)-Mel (AGTO-G015M)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
Afuco™ Anti-Human CTLA4 ADCC Therapeutic Antibody (JMW-3B3), ADCC Enhanced (AFC-185CL)
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- Species Reactivity: Human
- Type: ADCC enhanced antibody
Afuco™ Anti-Human CD40 ADCC Therapeutic Antibody (APX005), ADCC Enhanced (AFC-120CL)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
Anti-CTLA4 immunotoxin (scFv)-Sap (AGTO-G015S)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
Anti-Human CTLA4 Therapeutic Antibody (JMW-3B3) (TAB-195CL)
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- Species Reactivity: Human
- Type: Antibody
Anti-Human CD40 Therapeutic Antibody (APX005) (TAB-126CL)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
- Application: Block, Cyt, FuncS, Inhib
Anti-CD40 immunotoxin G28-5 (scFv)-PE (AGTO-G079E)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
Anti-Human CTLA4 Therapeutic Antibody (Ticilimumab (Tremelimumab)) (TAB-206)
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG2
- Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Anti-CTLA4 immunotoxin (scFv)-PE (AGTO-G015E)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
Anti-Human CD40 Therapeutic Antibody (Dacetuzumab) (TAB-152)
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1
- Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Anti-CD40 Therapeutic Antibody (Lucatumumab) (TAB-759)
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: ELISA, FC, IP, FuncS, IF, Neut, IHC
Mouse Anti-CTLA4 Recombinant Antibody (clone ANC152.2/8H5); Fab Fragment (DrMAB-987)
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC, ELISA
Anti-Human CD40 Therapeutic Antibody (Teneliximab) (TAB-262)
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: IgG1
- Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
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