AibGenesis™ Rabbit Anti-FGFR3 Recombinant Antibody (AibG-Rb-FG416)
CAT#: VS-0426-FY416
Engineered through our AI-powered antibody discovery platform, this Rabbit IgG targets FGFR3 (CD333). Validated for WB, IHC, and IF in Human samples, it provides high-fidelity detection for studying fibroblast growth factor receptor signaling and related skeletal dysplasias or oncogenic mutations.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67204/1419_D10_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67204/1382_D10_2_blue_green.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4231/11838_B_7_5.jpg
Normal Tissue
Figure 4 Testis
Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4231/11838_A_6_6.jpg
Normal Tissue
Figure 5 Skin
Cells in basal layer
Staining: High
Intensity: Strong
Quantity:>75%
Cells in spinous layer
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Langerhans cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4231/11838_B_8_1.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (CACO-2, HaCaT, Hep G2, NTERA-2, RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000068078-FGFR3
❮
❯
Specifications
- Immunogen
- Human
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human FGFR3
- Species Reactivity
- Human
- Clone
- AibG-Rb-FG416
- Applications
- Western Blot, Immunohistochemistry, Immunocytochemistry, Immunofluorescence
- Conjugate
- Unconjugated, Biotin and FITC are available.
- Related Disease
- Achondroplasia
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- 50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% Glycerol, 0.05% Protective protein
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (1:500-1:1000), Immunohistochemistry (1:50-1:100), Immunocytochemistry/Immunofluorescence (1:50-1:200)
Target
- Alternative Names
- FGFR3; JTK4; Fibroblast growth factor receptor 3; FGFR-3; CD antigen CD333
- Gene ID
- 2261
- UniProt ID
- P22607
- Long Name
- Fibroblast Growth Factor Receptor 3
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
- Cellular Localization
- Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Secreted
- Post Translation Modifications
- Autophosphorylated.
Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues.
Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer.
Phosphorylation at Tyr-724 is essential for stimulation of cell proliferation and activation of PIK3R1, STAT1 and MAP kinase signaling.
Phosphorylation at Tyr-760 is required for interaction with PIK3R1 and PLCG1.
Ubiquitinated.
Is rapidly ubiquitinated after ligand binding and autophosphorylation, leading to receptor internalization and degradation.
Subject to both proteasomal and lysosomal degradation.
N-glycosylated in the endoplasmic reticulum.
The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus.
Glycosylation at Asn98, Asn225, Asn262, Asn294, Asn315, and Asn328 (NX_P22607 [NX_P22607-1])
Modification sites at PhosphoSitePlus (P22607)
Glycosylation from GlyGen (P22607) 7 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_006713931.1; XP_006713932.1; XP_006713933.1; XP_006713934.1; XP_006713936.1
- Function
- Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation.
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Related Diseases
Bladder Cancer
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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