The product is a recombinant monoclonal antibody that targets CD40. In cynomolgus monkeys, the product was assessed for its capacity to inhibit primary and secondary humoral immune responses to T cell-dependent antigens. To evaluate its in vitro efficacy, recombinant forms were created by fusing variable regions to human constant regions.
Figure 1 The results of in vitro assays testing chimeric and humanized antibody.
The binding of chi220 and h220v3 to hCD40-mG2b in an ELISA based assay.
Figure 2 The results of in vitro assays testing chimeric and humanized antibody.
The inhibition of sgp39-mediated costimulation of human B cells with anti-human CD40 mAbs.
Figure 3 The IgM Anti-SRBC antibody response.
FIG. A shows the results from monkeys that received 10, 40 or 100 mg/kg chi220. FIG. B shows the results from monkeys that received 0.1 or 1 mg/kg chi220.
Figure 4 The IgG Anti-SRBC antibody response.
FIG. A shows the results from monkeys that received 10, 40 or 100 mg/kg chi220. FIG. B shows the results from monkeys that received 0.1 or 1 mg/kg chi220.
Figure 5 The anti-OVA antibody response in primates.
FIG. A shows the results of analysis for IgM anti-OVA antibodies. FIG. B shows the results of analysis for IgG anti-OVA antibodies.
Figure 6 The anti-KLH antibody response in primates.
FIG. A shows the results of analysis for IgM anti-KLH antibodies. FIG. B shows the results of analysis for IgG anti-KLH antibodies.
Figure 7 A graph showing peripheral B cell count of rhesus macaques treated with mouse-rhesus chimeric forms of 2C10 engineered to contain either rhesus IgG1 (2C1OR1) or IgG4 (2C10R4) heavy chain constant regions, and chimeric IgGl forms of anti-CD40 3A8 (3A8R1) or anti-CD40 Chi220 (Chi220).
All animals were immunized with 4-hydroxy-3-nitrophenylacetyl-conjugated keyhole limpet hemocyanin (KLH) after the first antibody treatment.
Figure 8 A graph showing results from a competitive blockade assay using human PBMCs incubated with increasing concentrations of 2C10, 3A8, or Chi220 antibodies and stained with an APC- conjugated 2C10 to assess the ability of each antibody to cross-block 2C10.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-759 | Anti-CD40 Recombinant Antibody (Lucatumumab) | ELISA, FC, IP, FuncS, IF, Neut, IHC | IgG1 - kappa |
TAB-195LC-F(E) | Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-195LC-F(E)) | ELISA | Human Fab |
TAB-196LC-F(E) | Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-196LC-F(E)) | ELISA | Human Fab |
TAB-197LC-F(E) | Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-197LC-F(E)) | ELISA | Human Fab |
TAB-470CQ | Anti-Human CD40 Recombinant Antibody (Selicrelumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G079E | Anti-CD40 immunotoxin G28-5 (scFv)-PE | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-189LC | Anti-Human CD40 Recombinant Antibody (F4) | SPR, ELISA | Humanized antibody |
TAB-190LC | Anti-Human CD40 Recombinant Antibody (L3.17) | SPR, ELISA | Humanized antibody |
TAB-194LC | Human Anti-CD40 Recombinant Antibody (TAB-194LC) | ELISA | Humanized IgG1, κ |
TAB-200LC | Human Anti-CD40 Recombinant Antibody (TAB-200LC) | ELISA | Human IgG1, κ |
TAB-204LC | Human Anti-CD40 Recombinant Antibody (TAB-204LC) | SPR, ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-202LC | Anti-CD40 Recombinant Antibody (TAB-202LC) | ELISA, FC, FuncS | Chimeric (mouse/rhesus) IgG1 |
TAB-203LC | Anti-CD40 Recombinant Antibody (TAB-203LC) | ELISA, FC, FuncS | Chimeric (mouse/rhesus) IgG4 |
TAB-188LC-S(P) | Anti-Human CD40 Recombinant Antibody scFv Fragment (chi220) | SPR, ELISA | Chimeric antibody (mouse/human) |
TAB-192LC-F(E) | Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-192LC-F(E)) | ELISA | Chimeric (mouse/human) Fab |
TAB-193LC-F(E) | Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-193LC-F(E)) | ELISA | Chimeric (mouse/human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-207LC-S(P) | Mouse Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-207LC-S(P)) | ELISA | Mouse scFv |
TAB-208LC-S(P) | Mouse Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-208LC-S(P)) | ELISA | Mouse scFv |
TAB-209LC-S(P) | Mouse Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-209LC-S(P)) | ELISA | Mouse scFv |
TAB-199LC-F(E) | Rat Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-199LC-F(E)) | ELISA | Rat Fab |
TAB-201LC-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-201LC-F(E)) | FC, ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-362CQ | Human Anti-CD40 Recombinant Antibody (clone 5D12) | Block, ELISA, FC, SPR, IP, IHC | Human IgG4, κ |
NEUT-363CQ | Mouse Anti-CD40 Recombinant Antibody (clone 5C3) | FC, Block, Activ | Mouse IgG1, κ |
NEUT-365CQ | Hamster Anti-CD40 Recombinant Antibody (clone HM40-3) | FC, Block, Costim, IHC | Hamster IgM |
NEUT-366CQ | Rat Anti-CD40 Recombinant Antibody (clone MAB0819) | Block, Activ | Rat IgG2 |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-364CQ | Mouse Anti-CD40 Recombinant Antibody (clone CBL829) | WB, Neut | Mouse IgG2b, κ |
NEUT-367CQ | Mouse Anti-CD40 Recombinant Antibody (clone CBL013) | WB, IHC, Neut | Mouse IgG2 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4059 | Hi-Affi™ Rabbit Anti-CD40 Recombinant Antibody (clone SI126DS) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-105LC | Human Anti-CD40 Recombinant Antibody (MOB-105LC) | FC, FuncS | Human IgG1, κ |
MOB-106LC | Human Anti-CD40 Recombinant Antibody (MOB-106LC) | FC, FuncS, ELISA | Human IgG2, κ |
MOB-107LC | Human Anti-CD40 Recombinant Antibody (MOB-107LC) | FC, FuncS, ELISA | Human IgG2, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-021CN | Human Anti-CD40 Recombinant Antibody (NS-021CN) | ELISA, IF, Block, FuncS | Human IgG |
NS-021CN-F(E) | Human Anti-CD40 Recombinant Antibody; Fab Fragment (NS-021CN-F(E)) | ELISA | Human Fab |
NS-021CN-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (NS-021CN-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1110LY | Mouse Anti-CD40 Recombinant Antibody (clone CBL020) | ELISA | Mouse IgG |
HPAB-M0481-YC | Human Anti-CD40 Recombinant Antibody (HPAB-M0481-YC) | ELISA, FC | Human IgG |
HPAB-M0482-YC | Human Anti-CD40 Recombinant Antibody (HPAB-M0482-YC) | ELISA, FC | Human IgG |
HPAB-M0483-YC | Human Anti-CD40 Recombinant Antibody (HPAB-M0483-YC) | ELISA, FC | Human IgG |
HPAB-M0484-YC | Human Anti-CD40 Recombinant Antibody (HPAB-M0484-YC) | ELISA, FC | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1110LY-F(E) | Mouse Anti-CD40 Recombinant Antibody (clone CBL020); Fab Fragment | ELISA | Mouse Fab |
HPAB-1662LY-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1662LY-F(E)) | ELISA, RIA | Mouse Fab |
HPAB-1663LY-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1663LY-F(E)) | ELISA, RIA | Mouse Fab |
HPAB-1664LY-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1664LY-F(E)) | ELISA, RIA | Mouse Fab |
HPAB-1665LY-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1665LY-F(E)) | ELISA, RIA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-152 | Afuco™ Anti-CD40 ADCC Recombinant Antibody (Dacetuzumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-262 | Afuco™ Anti-CD40 ADCC Recombinant Antibody (Teneliximab), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
AFC-TAB-759 | Afuco™ Anti-CD40 ADCC Recombinant Antibody (Lucatumumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
AFC-TAB-470CQ | Afuco™ Anti-CD40 ADCC Recombinant Antibody (Selicrelumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
AFC-TAB-006ML | Afuco™ Anti-CD40 ADCC Recombinant Antibody (Bleselumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0264-YJ-S(P) | Mouse Anti-CD40 Recombinant Antibody (clone 2C5); scFv Fragment | ELISA, Agonist | Mouse scFv |
HPAB-1272WJ-S(P) | Human Anti-CD40 Recombinant Antibody (clone F2-103); scFv Fragment | ELISA, WB | Human scFv |
HPAB-1273WJ-S(P) | Human Anti-CD40 Recombinant Antibody (clone F5-157); scFv Fragment | ELISA, WB | Human scFv |
HPAB-1274WJ-S(P) | Human Anti-CD40 Recombinant Antibody (clone F5-77); scFv Fragment | ELISA, WB | Human scFv |
HPAB-1834-FY-F(E) | Human Anti-CD40 Recombinant Antibody (clone 21.4.1); scFv Fragment | Agonist, Activ | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1218WJ | Recombinant Llama Anti-CD40 Single Domain Antibody (CD40-1) | ELISA | Llama VHH |
HPAB-1219WJ | Recombinant Llama Anti-CD40 Single Domain Antibody (CD40-2) | ELISA | Llama VHH |
HPAB-1220WJ | Recombinant Llama Anti-CD40 Single Domain Antibody (CD40-3) | ELISA | Llama VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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