Anti-Human CD40 Recombinant Antibody (chi220) (CAT#: TAB-188LC)

The product is a recombinant monoclonal antibody that targets CD40. In cynomolgus monkeys, the product was assessed for its capacity to inhibit primary and secondary humoral immune responses to T cell-dependent antigens. To evaluate its in vitro efficacy, recombinant forms were created by fusing variable regions to human constant regions.


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  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
ELISA

Figure 1 The results of in vitro assays testing chimeric and humanized antibody.

Figure 1 The results of in vitro assays testing chimeric and humanized antibody.

The binding of chi220 and h220v3 to hCD40-mG2b in an ELISA based assay.

Inhib

Figure 2 The results of in vitro assays testing chimeric and humanized antibody.

Figure 2 The results of in vitro assays testing chimeric and humanized antibody.

The inhibition of sgp39-mediated costimulation of human B cells with anti-human CD40 mAbs.

FuncS

Figure 3 The IgM Anti-SRBC antibody response.

Figure 3 The IgM Anti-SRBC antibody response.

FIG. A shows the results from monkeys that received 10, 40 or 100 mg/kg chi220. FIG. B shows the results from monkeys that received 0.1 or 1 mg/kg chi220.

FuncS

Figure 4 The IgG Anti-SRBC antibody response.

Figure 4 The IgG Anti-SRBC antibody response.

FIG. A shows the results from monkeys that received 10, 40 or 100 mg/kg chi220. FIG. B shows the results from monkeys that received 0.1 or 1 mg/kg chi220.

FuncS

Figure 5 The anti-OVA antibody response in primates.

Figure 5 The anti-OVA antibody response in primates.

FIG. A shows the results of analysis for IgM anti-OVA antibodies. FIG. B shows the results of analysis for IgG anti-OVA antibodies.

FuncS

Figure 6 The anti-KLH antibody response in primates.

Figure 6 The anti-KLH antibody response in primates.

FIG. A shows the results of analysis for IgM anti-KLH antibodies. FIG. B shows the results of analysis for IgG anti-KLH antibodies.

Figure 7 A graph showing peripheral B cell count of rhesus macaques treated with mouse-rhesus chimeric forms of 2C10 engineered to contain either rhesus IgG1 (2C1OR1) or IgG4 (2C10R4) heavy chain constant regions, and chimeric IgGl forms of anti-CD40 3A8 (3A8R1) or anti-CD40 Chi220 (Chi220).

Figure 7 A graph showing peripheral B cell count of rhesus macaques treated with mouse-rhesus chimeric forms of 2C10 engineered to contain either rhesus IgG1 (2C1OR1) or IgG4 (2C10R4) heavy chain constant regions, and chimeric IgGl forms of anti-CD40 3A8 (3A8R1) or anti-CD40 Chi220 (Chi220).

All animals were immunized with 4-hydroxy-3-nitrophenylacetyl-conjugated keyhole limpet hemocyanin (KLH) after the first antibody treatment.

Block

Figure 8 A graph showing results from a competitive blockade assay using human PBMCs incubated with increasing concentrations of 2C10, 3A8, or Chi220 antibodies and stained with an APC- conjugated 2C10 to assess the ability of each antibody to cross-block 2C10.

Figure 8 A graph showing results from a competitive blockade assay using human PBMCs incubated with increasing concentrations of 2C10, 3A8, or Chi220 antibodies and stained with an APC- conjugated 2C10 to assess the ability of each antibody to cross-block 2C10.


Specifications

  • Host Species
  • Human
  • Derivation
  • Chimeric (mouse/human)
  • Type
  • Chimeric antibody (mouse/human)
  • Specificity
  • Human
  • Clone
  • chi220
  • Applications
  • SPR, ELISA, Inhib, FuncS
  • Related Disease
  • Arthritis, Skin transplantation

Applications

  • Application Notes
  • This antibody has been tested for use in Enzyme-linked Immunosorbent Assay, Inhibition and Functional Assay. Please see the Published Data for further information.

Target

  • Alternative Names
  • CD40; p50; Bp50; CDW40; TNFRSF5

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone chi220"

See other products for "CD40"

Immunotoxin

CAT Product Name Application Type
AGTO-G079E Anti-CD40 immunotoxin G28-5 (scFv)-PE Cytotoxicity assay, Function study

Humanized Antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-202LC Anti-CD40 Recombinant Antibody (TAB-202LC) ELISA, FC, FuncS Chimeric (mouse/rhesus) IgG1
TAB-203LC Anti-CD40 Recombinant Antibody (TAB-203LC) ELISA, FC, FuncS Chimeric (mouse/rhesus) IgG4
TAB-188LC-S(P) Anti-Human CD40 Recombinant Antibody scFv Fragment (chi220) SPR, ELISA Chimeric antibody (mouse/human)
TAB-192LC-F(E) Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-192LC-F(E)) ELISA Chimeric (mouse/human) Fab
TAB-193LC-F(E) Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-193LC-F(E)) ELISA Chimeric (mouse/human) Fab

Blocking Antibody

CAT Product Name Application Type
NEUT-362CQ Human Anti-CD40 Recombinant Antibody (clone 5D12) Block, ELISA, FC, SPR, IP, IHC Human IgG4, κ
NEUT-363CQ Mouse Anti-CD40 Recombinant Antibody (clone 5C3) FC, Block, Activ Mouse IgG1, κ
NEUT-365CQ Hamster Anti-CD40 Recombinant Antibody (clone HM40-3) FC, Block, Costim, IHC Hamster IgM
NEUT-366CQ Rat Anti-CD40 Recombinant Antibody (clone MAB0819) Block, Activ Rat IgG2

Neutralizing Antibody

CAT Product Name Application Type
NEUT-364CQ Mouse Anti-CD40 Recombinant Antibody (clone CBL829) WB, Neut Mouse IgG2b, κ
NEUT-367CQ Mouse Anti-CD40 Recombinant Antibody (clone CBL013) WB, IHC, Neut Mouse IgG2

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4059 Hi-Affi™ Rabbit Anti-CD40 Recombinant Antibody (clone SI126DS) ELISA Rabbit IgG

Agonistic Antibody

CAT Product Name Application Type
MOB-105LC Human Anti-CD40 Recombinant Antibody (MOB-105LC) FC, FuncS Human IgG1, κ
MOB-106LC Human Anti-CD40 Recombinant Antibody (MOB-106LC) FC, FuncS, ELISA Human IgG2, κ
MOB-107LC Human Anti-CD40 Recombinant Antibody (MOB-107LC) FC, FuncS, ELISA Human IgG2, κ

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-152 Afuco™ Anti-CD40 ADCC Recombinant Antibody (Dacetuzumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-262 Afuco™ Anti-CD40 ADCC Recombinant Antibody (Teneliximab), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody
AFC-TAB-759 Afuco™ Anti-CD40 ADCC Recombinant Antibody (Lucatumumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody
AFC-TAB-470CQ Afuco™ Anti-CD40 ADCC Recombinant Antibody (Selicrelumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody
AFC-TAB-006ML Afuco™ Anti-CD40 ADCC Recombinant Antibody (Bleselumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, Inhib ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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