Recombinant Anti-CD40 (CRD1 x ECD) Biparatopic Antibody, Tandem scFv (CAT#: VS-0525-YC30)

• Host Animal 1
• Human

• Host Animal 2
• Human

• Specificity
• Human CD40

• Species Reactivity
• Human

• Type
• Tandem scFv

• Valency
• 1 + 1

• Epitope 1
• Cysteine-rich domain 1 (CRD1)

• Epitope 2
• Extracellular domain

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA, FC, Neut, IHC, IP, IF

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• CD40 Molecule

• Introduction
• The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

• Alternative Names
• CD40; CD40 molecule, TNF receptor superfamily member 5; TNFRSF5, tumor necrosis factor receptor superfamily, member 5; tumor necrosis factor receptor superfamily member 5; Bp50; p5

• Gene ID
• 958

• UniProt ID
• P25942

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