Rat Anti-CD40 (clone FGK45) scFv-Fc Chimera

Name: Rat Anti-CD40 (clone FGK45) scFv-Fc Chimera
SKU: VS-0325-FY89
Rating: 5 (1 reviews)

CAT#: VS-0325-FY89

The anti-CD40 scFv-Fc antibody is designed to target the CD40 receptor, a key molecule involved in immune cell activation and regulation. It has potential therapeutic applications in modulating immune responses, particularly in cancer immunotherapy and autoimmune diseases. This antibody format combines the specificity of the scFv fragment with the extended half-life provided by the Fc region, enhancing its stability and effectiveness.

Gene Expression

Normal Tissue Figure 1 Lymph node

Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72868/156401_A_8_8.jpg

Normal Tissue Figure 2 Tonsil

Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31567/156626_A_6_8.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40

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Specifications

Host Species
Rat

Type
Rat IgG1, scFv-Fc

Specificity
FGK45 recognizes an epitope on mouse CD40.

Species Reactivity
Mouse

Clone
FGK45

Applications
Flow Cytometry, Western Blot, Agonist

Related Disease
Cancer, autoimmune disease

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Shipping
Ice packs

Applications

Application Notes
It acts as a CD40 agonist to enhance immune responses.

Target

Alternative Names
CD40 Molecule; CD40 Molecule, TNF Receptor Superfamily Member 5; CD40L Receptor; TNFRSF5; CDW40; Bp50; Tumor Necrosis Factor Receptor Superfamily, Member 5

Gene ID
958

UniProt ID
P25942

Long Name
CD40 Molecule

Cellular Localization
Cell membrane; Membrane; Secreted

Protein Refseq
NP_001241.1; NP_001289682.1; NP_001309351.1

Function
Receptor for TNFSF5/CD40LG (PubMed:31331973).
Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).

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Related Diseases

Asthma

Systemic Lupus Erythematosus

Primary Immunodeficiency

Allograft Rejection

Autoimmune Thyroid Disease

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS-0325-FY89.pdf

MSDS

MSDS - VS-0325-FY89.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Secondary Antibody

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