Rat Anti-CD40 (clone FGK45) scFv-Fc Chimera (CAT#: VS-0325-FY89)
The anti-CD40 scFv-Fc antibody is designed to target the CD40 receptor, a key molecule involved in immune cell activation and regulation. It has potential therapeutic applications in modulating immune responses, particularly in cancer immunotherapy and autoimmune diseases. This antibody format combines the specificity of the scFv fragment with the extended half-life provided by the Fc region, enhancing its stability and effectiveness.
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Normal Tissue
RNA Expression
Figure 1 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72868/156401_A_8_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72868/156401_A_8_8.jpg
Figure 2 Tonsil
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31567/156626_A_6_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31567/156626_A_6_8.jpg
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40
Specifications
- Host Species
- Rat
- Type
- Rat IgG1, scFv-Fc
- Specificity
- FGK45 recognizes an epitope on mouse CD40.
- Species Reactivity
- Mouse
- Clone
- FGK45
- Applications
- Flow Cytometry, Western Blot, Agonist
- Related Disease
- Cancer, autoimmune disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- It acts as a CD40 agonist to enhance immune responses.
Target
- Alternative Names
- CD40 Molecule; CD40 Molecule, TNF Receptor Superfamily Member 5; CD40L Receptor; TNFRSF5; CDW40; Bp50; Tumor Necrosis Factor Receptor Superfamily, Member 5
- Gene ID
- 958
- UniProt ID
- P25942
- Long Name
- CD40 Molecule
- Cellular Localization
- Cell membrane; Membrane; Secreted
- Protein Refseq
- NP_001241.1; NP_001289682.1; NP_001309351.1
- Function
- Receptor for TNFSF5/CD40LG (PubMed:31331973).
Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).
Recommended Products
Secondary Antibody
Related Resources
Asthma
Systemic Lupus Erythematosus
Primary Immunodeficiency
Allograft Rejection
Autoimmune Thyroid Disease
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-262 | Anti-Human CD40 Recombinant Antibody (TAB-262) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG1 |
| TAB-188LC-F(E) | Anti-Human CD40 Recombinant Antibody Fab Fragment (chi220) | SPR, ELISA | Chimeric antibody (mouse/human) |
| TAB-192LC-F(E) | Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-192LC-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| TAB-193LC-F(E) | Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-193LC-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| TAB-202LC-F(E) | Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-202LC-F(E)) | FC, ELISA | Chimeric antibody (mouse/rhesus) |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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