Recombinant Anti-CD40 Biparatopic Antibody, Tandem scFv (Bleselumab x Selicrelumab) (CAT#: VS-0525-YC208)

• Host Animal 1
• Human

• Host Animal 2
• Human

• Specificity
• Human CD40

• Species Reactivity
• Human

• Type
• Tandem scFv

• Valency
• 1 + 1

• Clone 1
• Bleselumab

• Clone 2
• Selicrelumab

• Epitope 1
• Both CRD2 and CRD1, exactly overlapping with the CD40L binding site.

• Epitope 2
• The outer A-module of the membrane proximal domain (D1a)

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA, FC, IP, IF, IHC

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• CD40 Molecule

• Introduction
• This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

• Alternative Names
• Tumor necrosis factor receptor superfamily member 5; TNFRSF5; p50

• Gene ID
• 958

• UniProt ID
• P25942

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