Recombinant Anti-CD40 Biparatopic Antibody, Tandem scFv (Bleselumab x Selicrelumab)

Name: Recombinant Anti-CD40 Biparatopic Antibody, Tandem scFv (Bleselumab x Selicrelumab)
SKU: VS-0525-YC208
Rating: 5 (1 reviews)

CAT#: VS-0525-YC208

The Recombinant Anti-CD40 Biparatopic Antibody, Tandem scFv (Bleselumab x Selicrelumab) is a biparatopic antibody (bpAb) that binds two distinct CD40 epitopes. This construct employs a tandem scFv design. It N-terminally fuses the Bleselumab scFv (targeting an epitope on both CRD2 and CRD1, precisely overlapping the CD40L binding site) to the Selicrelumab scFv (which targets the outer A-module of the membrane-proximal domain (D1a)).

Gene Expression

Normal Tissue Figure 1 Lymph node

Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72868/156401_A_8_8.jpg

Normal Tissue Figure 2 Tonsil

Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31567/156626_A_6_8.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40

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Specifications

Host Animal 1
Human

Host Animal 2
Human

Specificity
Human CD40

Species Reactivity
Human

Type
Tandem scFv

Valency
1 + 1

Clone 1
Bleselumab

Clone 2
Selicrelumab

Epitope 1
Both CRD2 and CRD1, exactly overlapping with the CD40L binding site.

Epitope 2
The outer A-module of the membrane proximal domain (D1a)

Purity
>90%

Purification
Affinity purified

Applications
ELISA, FC, IP, IF, IHC

Concentration
Lot specific

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

Long Name
CD40 Molecule

Target

Introduction
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Alternative Names
Tumor necrosis factor receptor superfamily member 5; TNFRSF5; p50

Gene ID
958

UniProt ID
P25942

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Related Diseases

Asthma

Systemic Lupus Erythematosus

Primary Immunodeficiency

Allograft Rejection

Autoimmune Thyroid Disease

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - VS-0525-YC208.pdf

MSDS

MSDS - VS-0525-YC208.pdf

COA

Certificate of Analysis Lookup

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Protocol & Troubleshooting

Immunofluorescence (IF)

Immunohistochemistry (IHC)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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TAB-0063CL-S(P)	Anti-Human CD40 Recombinant Antibody scFv Fragment (PPAT-071-03)	ELISA, FuncS
TAB-0064CL-S(P)	Anti-Human CD40 Recombinant Antibody scFv Fragment (PPAT-071-04)	ELISA, FuncS
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CAT	Product Name	Application	Type
TAB-189LC-S(P)	Anti-Human CD40 Recombinant Antibody scFv Fragment (F4)	SPR, ELISA	Humanized antibody
TAB-190LC-S(P)	Anti-Human CD40 Recombinant Antibody scFv Fragment (L3.17)	SPR, ELISA	Humanized antibody
TAB-194LC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-194LC-S(P))	ELISA	Humanized scFv
TAB-200LC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-200LC-S(P))	ELISA	Human scFv
TAB-204LC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-204LC-S(P))	SPR, ELISA	Human scFv

CAT	Product Name	Application	Type
TAB-195LC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-195LC-S(P))	ELISA	Human scFv
TAB-196LC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-196LC-S(P))	ELISA	Human scFv
TAB-197LC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-197LC-S(P))	ELISA	Human scFv
TAB-198LC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-198LC-S(P))	ELISA	Human scFv
TAB-006ML	Anti-Human CD40 Recombinant Antibody (Bleselumab)	ELISA, IHC, FC, IP, IF, Inhib	IgG4, κ

CAT	Product Name	Application	Type
TAB-188LC-F(E)	Anti-Human CD40 Recombinant Antibody Fab Fragment (chi220)	SPR, ELISA	Chimeric antibody (mouse/human)
TAB-192LC-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-192LC-F(E))	ELISA	Chimeric (mouse/human) Fab
TAB-193LC-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-193LC-F(E))	ELISA	Chimeric (mouse/human) Fab
TAB-202LC-F(E)	Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-202LC-F(E))	FC, ELISA	Chimeric antibody (mouse/rhesus)
TAB-203LC-F(E)	Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-203LC-F(E))	FC, ELISA	Chimeric antibody (mouse/rhesus)

CAT	Product Name	Application	Type
NEUT-362CQ	Human Anti-CD40 Recombinant Antibody (clone 5D12)	Block, ELISA, FC, SPR, IP, IHC	Human IgG4, κ
NEUT-363CQ	Mouse Anti-CD40 Recombinant Antibody (clone 5C3)	FC, Block, Activ	Mouse IgG1, κ
NEUT-366CQ	Rat Anti-CD40 Recombinant Antibody (clone MAB0819)	Block, Activ	Rat IgG2

CAT	Product Name	Application	Type
NEUT-364CQ	Mouse Anti-CD40 Recombinant Antibody (clone CBL829)	WB, Neut	Mouse IgG2b, κ
NEUT-367CQ	Mouse Anti-CD40 Recombinant Antibody (clone CBL013)	WB, IHC, Neut	Mouse IgG2

CAT	Product Name	Application	Type
NEUT-365CQ	Hamster Anti-CD40 Recombinant Antibody (clone HM40-3)	FC, Block, Costim, IHC	Hamster IgM

CAT	Product Name	Application	Type
MOR-4059	Hi-Affi™ Rabbit Anti-CD40 Recombinant Antibody (clone SI126DS)	ELISA	Rabbit IgG

CAT	Product Name	Application	Type
MOB-105LC	Human Anti-CD40 Recombinant Antibody (MOB-105LC)	FC, FuncS	Human IgG1, κ
MOB-106LC	Human Anti-CD40 Recombinant Antibody (MOB-106LC)	FC, FuncS, ELISA	Human IgG2, κ
MOB-107LC	Human Anti-CD40 Recombinant Antibody (MOB-107LC)	FC, FuncS, ELISA	Human IgG2, κ
VS-0724-XY18	Mouse Anti-CD40 Agonistic Antibody (VS-0724-XY18)	FC, Agonistic assays, CyTOF®, ICC	Mouse IgG2b
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CAT	Product Name	Application	Type
HPAB-0162-YC	Human Anti-CD40 Recombinant Antibody (HPAB-0162-YC)	FC	Human IgG
HPAB-0163-YC	Human Anti-CD40 Recombinant Antibody (HPAB-0163-YC)	FC	Human IgG
HPAB-0164-YC	Human Anti-CD40 Recombinant Antibody (HPAB-0164-YC)	FC, Agonist	Human IgG
HPAB-0165-YC	Human Anti-CD40 Recombinant Antibody (HPAB-0165-YC)	FC	Human IgG
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CAT	Product Name	Application	Type
NS-021CN	Human Anti-CD40 Recombinant Antibody (NS-021CN)	ELISA, IF, Block, FuncS	Human IgG
NS-021CN-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (NS-021CN-F(E))	ELISA	Human Fab
NS-021CN-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (NS-021CN-S(P))	ELISA	Human scFv

CAT	Product Name	Application	Type
HPAB-0138CQ-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-0138CQ-F(E))	ELISA, FC, IHC, Block	Human Fab
HPAB-0139CQ-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-0139CQ-F(E))	ELISA, FC, IHC, IP, Block	Human Fab
HPAB-1662LY-F(E)	Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1662LY-F(E))	ELISA, RIA	Mouse Fab
HPAB-1663LY-F(E)	Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1663LY-F(E))	ELISA, RIA	Mouse Fab
HPAB-1664LY-F(E)	Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1664LY-F(E))	ELISA, RIA	Mouse Fab

CAT	Product Name	Application	Type
HPAB-0138CQ-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-0138CQ-S(P))	ELISA, FC, IHC, Block	Human scFv
HPAB-0139CQ-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-0139CQ-S(P))	ELISA, FC, IHC, IP, Block	Human scFv
HPAB-1662LY-S(P)	Mouse Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-1662LY-S(P))	ELISA, RIA	Mouse scfv
HPAB-1663LY-S(P)	Mouse Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-1663LY-S(P))	ELISA, RIA	Mouse scfv
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CAT	Product Name	Application	Type
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AFC-TAB-759	Afuco™ Anti-CD40 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-759)	ELISA, FC, IP, FuncS, IF, Neut	ADCC enhanced antibody
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HPAB-1218WJ	Recombinant Llama Anti-CD40 Single Domain Antibody (HPAB-1218WJ)	ELISA	Llama VHH
HPAB-1219WJ	Recombinant Llama Anti-CD40 Single Domain Antibody (HPAB-1219WJ)	ELISA	Llama VHH
HPAB-1220WJ	Recombinant Llama Anti-CD40 Single Domain Antibody (HPAB-1220WJ)	ELISA	Llama VHH

CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
VS-0924-YC117	Mouse Anti-CD40 Recombinant Antibody Hexamer (VS-0924-YC117), CDC Enhanced	ELISA, ADCC, CDC	Antibody hexamer
VS-0924-YC118	Human Anti-CD40 Recombinant Antibody Hexamer (VS-0924-YC118), CDC Enhanced	ELISA, Block, FC, IF, Activ, CDC	Antibody hexamer

CAT	Product Name	Application	Type
VS-0225-XY52	CytoStream™ Armenian Hamster Anti-CD40 Recombinant Antibody (clone HM40-3)	FC, Block	Armenian Hamster IgM, kappa

CAT	Product Name	Application	Type
VS-0325-FY89	Rat Anti-CD40 (clone FGK45) scFv-Fc Chimera	FC, WB, Agonist	Rat IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC514	Recombinant Anti-CD40 Vesicular Antibody, EV Displayed (VS-0425-YC514)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY1181	Anti-CD40 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC30	Recombinant Anti-CD40 (CRD1 x ECD) Biparatopic Antibody, Tandem scFv	ELISA, FC, Neut, IHC, IP, IF	Tandem scFv
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