Human Anti-CD40 Recombinant Antibody Hexamer (VS-0924-YC118), CDC Enhanced (CAT#: VS-0924-YC118)
The product is a human anti-CD40 antibody hexamer with enhanced CDC (complement-dependent cytotoxicity) activity. This hexameric IgG1 targeting human CD40 incorporates hexamerization-enhancing mutations, which facilitate hexamer formation to optimize C1q binding and boost CDC activity.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72868/156401_A_8_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72868/156401_A_8_8.jpg
Figure 2 Tonsil
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31567/156626_A_6_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31567/156626_A_6_8.jpg
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40
Specifications
- Host Species
- Human
- Type
- Antibody hexamer
- Specificity
- Human CD40
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- ELISA, Block, FC, IF, Activ, CDC
- Conjugate
- None
- Related Disease
- Autoimmune diseases
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CD40 Molecule; CD40 Molecule; TNF Receptor Superfamily Member 5; CD40L Receptor; TNFRSF5; CDW40; Bp50; Tumor Necrosis Factor Receptor Superfamily; Member 5;
- Gene ID
- 958
- UniProt ID
- P25942
- Long Name
- CD40 Molecule
Related Resources
Asthma
Systemic Lupus Erythematosus
Primary Immunodeficiency
Allograft Rejection
Autoimmune Thyroid Disease
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-759 | Anti-CD40 Recombinant Antibody (Lucatumumab) | ELISA, FC, IP, FuncS, IF, Neut, IHC | IgG1 - kappa |
| TAB-195LC | Human Anti-CD40 Recombinant Antibody (TAB-195LC) | ELISA, Agonist | Human IgG2 |
| TAB-196LC | Human Anti-CD40 Recombinant Antibody (TAB-196LC) | ELISA, Agonist | Human IgG2 |
| TAB-197LC | Human Anti-CD40 Recombinant Antibody (TAB-197LC) | ELISA, Agonist | Human IgG2 |
| TAB-198LC | Human Anti-CD40 Recombinant Antibody (TAB-198LC) | ELISA | Human IgG2 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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