What distinguishes polyclonal antibodies from monoclonal ones?

While monoclonal antibodies are homogeneous and selective to a single antigen, polyclonal antibodies are mixes that can target a number of antigens.

In order to prevent contamination, how should I manage antibodies?

In order to prevent contamination and ensure precise application, antibodies must be handled according to aseptic protocols while wearing personal protective equipment.

When using antibodies in research, are there any other factors to take into account?

Strict adherence to procedures, prevention of cross-contamination, and storage under suitable conditions are necessary to guarantee reliable and repeatable outcomes.

Anti-Human APP Recombinant Antibody (3D6)

CAT#: TAB-0809CLV

The anti-β-amyloid antibody 3D6 refers to a recombinant antibody expressed on the macrophage, the specific antibody can be used in the treatment of Alzheimer's Disease.

Published Data Gene Expression

Figure 1 Robust increases of extracellular amyloid-b deposits in 3D-differentiated hNPCs with FAD mutations.

Amyloid-β deposits in 6-week differentiated control and FAD ReN cells in 3D Matrigel (green, GFP; blue, 3D6; scale bar, 25 mm; arrowheads, extracellular amyloid-b deposits; right-most panels, 3D6 staining was pseudo-coloured to red).

Choi, S. H., Kim, Y. H., Hebisch, M., Sliwinski, C., Lee, S., D’Avanzo, C., ... & Klee, J. B. (2014). A three-dimensional human neural cell culture model of Alzheimer’s disease. Nature, 515(7526), 274.

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Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/if_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/60_E2_1_blue_red_green.jpg

Subcellular Location Figure 3 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/61_E2_1_blue_red_green.jpg

Normal Tissue Figure 4 Cerebral cortex

Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/157/2073_B_7_5.jpg

RNA Expression Figure 5 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP

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Specifications

Host Species
Mouse

Specificity
Human

Clone
3D6

Applications
IF

Related Disease
Alzheimer's disease

Applications

Application Notes
The antibody was validated for Immunofluorescence. For details, refer to Published Data.

Target

Alternative Names
APP; Amyloid Beta; amyloid beta (A4) precursor protein

Gene ID
351

UniProt ID
P05067

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Simple to operate

It is simple to handle and prepare the antibody. There were comprehensive usage instructions included with the product, so no more adjustments were required.

Consistent Storage

This antibody has not degraded after being stored for more than six months at -20°C. It keeps its reactivity well and is incredibly stable.

Minimal Background

The antibody shows minimal nonspecific binding even in the absence of 100% blocking, which makes it a dependable choice for our immunofluorescence research.

Q&As

What distinguishes polyclonal antibodies from monoclonal ones?

A: While monoclonal antibodies are homogeneous and selective to a single antigen, polyclonal antibodies are mixes that can target a number of antigens.
In order to prevent contamination, how should I manage antibodies?

A: In order to prevent contamination and ensure precise application, antibodies must be handled according to aseptic protocols while wearing personal protective equipment.
When using antibodies in research, are there any other factors to take into account?

A: Strict adherence to procedures, prevention of cross-contamination, and storage under suitable conditions are necessary to guarantee reliable and repeatable outcomes.

View the frequently asked questions answered by Creative Biolabs Support.

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# TAB-0809CLV, RRID: AB_3111798)

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-0809CLV.pdf

MSDS

MSDS - TAB-0809CLV.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Clone 3D6"

CAT
Product Name

See other products for "APP"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
MOB-1185z	Mouse Anti-APP Recombinant Antibody (clone 25F3)	WB, FC, ICC, IF, IHC	Mouse IgG1
MOB-043LC	Recombinant Mouse Anti-Mouse APP Antibody	WB, IP	Mouse IgG
HPAB-0241-FY	Mouse Anti-APP Recombinant Antibody (HPAB-0241-FY)	Inhib, FuncS	Mouse IgG1
HPAB-0242-FY	Human Anti-APP Recombinant Antibody (HPAB-0242-FY)	WB	Humanized IgG1
HPAB-0970-FY	Mouse Anti-APP Recombinant Antibody (HPAB-0970-FY)	ELISA	Mouse IgG

CAT	Product Name	Application	Type
NABG-016	Recombinant Anti-Human APP VHH Single Domain Antibody	CA, IP, IF, FuncS	Llama VHH
TAB-0019CL-VHH	Camelid Anti-APP Recombinant Antibody (TAB-0019CL-VHH)	IHC, WB	Camelid VHH
TAB-0020CL-VHH	Anti-Human APP VHH Single Domain Antibody (TAB-0020CL-VHH)	ELISA, IHC	Single domain antibody
TAB-0021CL-VHH	Anti-Human APP VHH Single Domain Antibody (TAB-0021CL-VHH)	ELISA, In vivo, FuncS	Single domain antibody
TAB-0022CL-VHH	Anti-Human APP VHH Single Domain Antibody (TAB-0022CL-VHH)	ELISA, In vivo, FuncS	Single domain antibody

CAT	Product Name	Application	Type
TAB-225	Anti-Human Abeta Recombinant Antibody (TAB-225)	WB, FuncS, IF, Neut, ELISA, FC, IP	IgG1
TAB-226	Anti-Human Abeta Recombinant Antibody (TAB-226)	WB, IF, IP, Neut, FuncS, ELISA, FC	IgG4 - kappa
TAB-0828CLV-F(E)	Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0828CLV-F(E))	ELISA	Humanized Fab
TAB-0829CLV-F(E)	Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0829CLV-F(E))	ELISA	Humanized Fab
TAB-0830CLV-F(E)	Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0830CLV-F(E))	ELISA	Humanized Fab

CAT	Product Name	Application	Type
TAB-229	Anti-Human Abeta Recombinant Antibody (TAB-229)	FuncS, IF, Neut, ELISA, FC, IP, ICC	IgG1 - kappa
TAB-0343CL	Human Anti-APP Recombinant Antibody (TAB-0343CL)	ELISA, Inhib	Human IgG
TAB-0344CL	Human Anti-APP Recombinant Antibody (TAB-0344CL)	ELISA	Human IgG
TAB-0343CL-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0343CL-S(P))	ELISA, FuncS, In vivo	Human scFv
TAB-0344CL-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0344CL-S(P))	ELISA, FuncS, In vivo	Human scFv

CAT	Product Name	Application	Type
TAB-0341CL-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0341CL-S(P))	ELISA, FuncS, In vivo	Mouse scFv
TAB-0342CL-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0342CL-S(P))	ELISA, FuncS, In vivo	Mouse scFv
TAB-0341CL-F(E)	Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-0341CL-F(E))	ELISA, FuncS, In vivo	Mouse Fab
TAB-0342CL-F(E)	Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-0342CL-F(E))	ELISA, FuncS, In vivo	Mouse Fab
TAB-255CQ-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-255CQ-S(P))	ELISA	Mouse scFv

CAT	Product Name	Application	Type
TAB-254CQ	Human Anti-APP Recombinant Antibody (TAB-254CQ)	ELISA	Chimeric (mouse/human) IgG1
TAB-254CQ-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-254CQ-S(P))	ELISA	Mouse scFv
TAB-0789CLV	Human Anti-APP Recombinant Antibody (TAB-0789CLV)	IP	Chimeric (mouse/human) IgG
TAB-0802CLV	Human Anti-APP Recombinant Antibody (TAB-0802CLV)	ELISA	Chimeric (mouse/human) IgG1, κ
TAB-0802CLV-F(E)	Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0802CLV-F(E))	ELISA	Chimeric (mouse/human) Fab

CAT	Product Name	Application	Type
BRD-0685MZ	Chicken Anti-APP Polyclonal IgY	IHC	Chicken antibody

CAT	Product Name	Application	Type
PABX-014	Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204)	WB, ELISA, FuncS	Rabbit IgG
PABX-014-F (E)	Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204); Fab Fragment	WB, ELISA, FuncS	Rabbit Fab
MOR-0220	Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone DS220AB)	ELISA, WB	Rabbit IgG
MOR-4539	Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone TH47DS)	IHC-P, ELISA	Rabbit IgG
MOR-0082-FY	Rabbit Anti-APP Recombinant Antibody (clone AFY0053)	ICC, IHC-P, WB	Rabbit IgG

CAT	Product Name	Application	Type
EPAF-0566CQ	Mouse Anti-APP Recombinant Antibody (clone 6E10)	ELISA	Mouse IgG
EPAF-0567CQ	Mouse Anti-APP Recombinant Antibody (clone 4G8)	ELISA, IHC	Mouse IgG2b
EPAF-0568CQ	Human Anti-APP Recombinant Antibody (clone HyL5)	ELISA, Inhib	Human IgM
EPAF-0569CQ	Mouse Anti-APP Recombinant Antibody (clone AB1-42)	IHC	Mouse IgG
EPAF-0570CQ	Human Anti-APP Recombinant Antibody (clone L11.3)	IHC, ELISA, Inhib	Human IgM

CAT	Product Name	Application	Type
NS-001CN	Human Anti-APP Recombinant Antibody (clone AS)	WB	Human IgG
NS-007CN	Mouse Anti-APP Recombinant Antibody (NS-007CN)	ELISA, FuncS	Mouse IgG1
NS-001CN-F(E)	Human Anti-APP Recombinant Antibody (clone AS); Fab Fragment	WB	Human Fab
NS-007CN-F(E)	Mouse Anti-APP Recombinant Antibody; Fab Fragment (NS-007CN-F(E))	ELISA	Mouse Fab
NS-001CN-S(P)	Human Anti-APP Recombinant Antibody (clone AS); scFv Fragment	WB	Human scFv

CAT	Product Name	Application	Type
PFBC-394	Mouse Anti-APP Recombinant Antibody (clone c#6); Fab Fragment	ELISA, WB, FuncS	Mouse Fab
PFBC-395	Mouse Anti-APP Recombinant Antibody (clone c#24); Fab Fragment	ELISA, WB, FuncS	Mouse Fab
HPAB-0241-FY-F(E)	Mouse Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0241-FY-F(E))	Inhib	Mouse Fab
HPAB-0242-FY-F(E)	Human Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0242-FY-F(E))	WB	Humanized Fab
HPAB-0732-FY-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0732-FY-S(P))	DB, ELISA	Mouse scFv

CAT	Product Name	Application	Type
PSBC-527	Mouse Anti-APP Recombinant Antibody (clone c#17); scFv Fragment	ELISA, WB, FuncS	Mouse scFv
HPAB-0008-YJ-S(P)	Mouse Anti-APP Recombinant Antibody (clone 508F); scFv Fragment	ELISA	Mouse scFv
HPAB-0732-FY-F(E)	Mouse Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0732-FY-F(E))	DB, ELISA	Mouse Fab
HPAB-0733-FY-F(E)	Mouse Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0733-FY-F(E))	DB, ELISA	Mouse Fab
HPAB-0735-FY-F(E)	Human Anti-APP Recombinant Antibody (clone H2L1); scFv Fragment	ELISA, FC, WB	Humanized scFv

CAT	Product Name	Application	Type
AFC-TAB-225	Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-225)	FuncS, IF, Neut, ELISA, FC	ADCC enhanced antibody
AFC-TAB-228	Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-228)	FuncS, IF, Neut, ELISA, FC	ADCC enhanced antibody
AFC-TAB-229	Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-229)	FuncS, IF, Neut, ELISA, FC, IP	ADCC enhanced antibody
AFC-TAB-227	Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-227)	ELISA, IP, FC, FuncS, Neut	ADCC enhanced antibody
AFC-TAB-226	Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-226)	IF, IP, Neut, FuncS, ELISA	ADCC enhanced antibody

CAT	Product Name	Application	Type
HPAB-0008-YJ	Mouse Anti-APP Recombinant Antibody (clone 508F)	ELISA	Mouse IgM

CAT	Product Name	Application	Type
VS-0424-XY17	AbPlus™ Anti-APP Magnetic Beads (DE2B4)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-1024-XY23	Mouse Anti-NHP APP Recombinant Antibody (VS-1024-XY23)	WB, ICC	Mouse IgG1

CAT	Product Name	Application	Type
VS-0325-FY6	Human Anti-APP (clone 2A7) scFv-Fc Chimera	ELISA	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC204	Recombinant Anti-APP Vesicular Antibody, EV Displayed (VS-0425-YC204)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application
VS-0525-XY469	Anti-APP Immunohistochemistry Kit	IHC
VS-0525-XY470	Anti-Mouse APP Immunohistochemistry Kit	IHC
VS-0525-XY471	Anti-Monkey APP Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC2	Recombinant Anti-APP Biparatopic Antibody, Tandem sdAb	ELISA, Inhib	Tandem sdAb
VS-0525-YC18	Recombinant Anti-APP (AA 3-7 x AA 12-28) Biparatopic Antibody, Tandem scFv (Clone h12A11v1 x Solanezumab)	ELISA, Neut, FC, IF, IP, WB	Tandem scFv
VS-0525-YC196	Recombinant Anti-APP (AA 1-5 x AA 13-28) Biparatopic Antibody, Tandem scFv	ELISA, FC, IF, IP, Neut, WB	Tandem scFv
VS-0525-YC198	Recombinant Anti-APP (AA 13-28 x AA 33-40) Biparatopic Antibody, Tandem scFv (Solanezumab x Ponezumab)	ELISA, FC, IF, IP, Neut, WB	Tandem scFv

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