What is the clone name of this scFv antibody?

This Anti-Human APP Recombinant Antibody scFv Fragment is derived from clone 3D6. It is an anti-β-amyloid antibody expressed on the macrophage.

What is the target of this antibody?

The antibody targets the Amyloid beta (A4) precursor protein (APP). The 3D6 clone specifically recognizes the β-amyloid peptide associated with Alzheimer's disease research.

Anti-Human APP Recombinant Antibody scFv Fragment (3D6)

CAT#: TAB-0809CLV-S(P)

The anti-β-amyloid antibody 3D6 refers to a scFv antibody expressed on the macrophage.The specific antibody can be used in the treatment of Alzheimer's Disease.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/if_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/60_E2_1_blue_red_green.jpg

Subcellular Location Figure 3 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/61_E2_1_blue_red_green.jpg

Normal Tissue Figure 4 Cerebral cortex

Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/157/2073_B_7_5.jpg

RNA Expression Figure 5 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP

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Specifications

Host Species
Mouse

Specificity
Human

Clone
3D6

Related Disease
Alzheimer's disease

Target

Alternative Names
APP; Amyloid Beta; amyloid beta (A4) precursor protein

Gene ID
351

UniProt ID
P05067

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Breast cancer biomarkers at key points during disease progression

High Affinity for Amyloid Beta

We used the 3D6 scFv fragment for research into Alzheimer's disease pathology. It binds to the amyloid beta peptide with high affinity. The scFv format is very convenient for our specific assay requirements where a full IgG molecule would be too large.

Validated Research Tool

This antibody fragment has been a reliable tool for detecting APP and its cleavage products in our macrophage models. The specificity of clone 3D6 is well-documented, and this recombinant version performs exactly as expected for our neurobiology studies.

Q&As

What is the clone name of this scFv antibody?

A: This Anti-Human APP Recombinant Antibody scFv Fragment is derived from clone 3D6. It is an anti-β-amyloid antibody expressed on the macrophage.
What is the target of this antibody?

A: The antibody targets the Amyloid beta (A4) precursor protein (APP). The 3D6 clone specifically recognizes the β-amyloid peptide associated with Alzheimer's disease research.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-0809CLV-S(P).pdf

MSDS

MSDS - TAB-0809CLV-S(P).pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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