Anti-Human APP Recombinant Antibody (2B12) (CAT#: TAB-0848CLV)
The anti-APP antibody 2B12 specifically binds amyloid precursor protein from which the β-amyloid is cleaved. By binding the APP and therefore reducing the accumulation or the release of β-amyloid, the antibody can be used in the treatment of conditions related with elevated levels of β-amyloid, such as Alzheimer's Disease.
Specific Inquiry
WB
Figure 1 Representative western blot of sAPPa incubated with or without BACE1 and 2B12, 2B3, control IgG, anti-N terminal APP IgG.
Only 2B12 and 2B3 inhibited the action of BACE1 in this system.
Thomas, R. S., Liddell, J. E., & Kidd, E. J. (2011). Anti‐amyloid precursor protein immunoglobulins inhibit amyloid‐β production by steric hindrance. The FEBS journal, 278(1), 167-178.
ELISA
Figure 2 Levels of intracellular APP as determined by ELISA.
After incubation with 2B3, 2B12, an anti-N-terminal APP IgG (N, MTS only) or a control irrelevant mouse IgG, all at 10 lgÆmL)1 for 48 h.
Thomas, R. S., Liddell, J. E., & Kidd, E. J. (2011). Anti‐amyloid precursor protein immunoglobulins inhibit amyloid‐β production by steric hindrance. The FEBS journal, 278(1), 167-178.
Specifications
- Immunogen
- Ka (spanning the β-secretase cleavage site in human APP)
- Host Species
- Mouse
- Specificity
- Human
- Clone
- 2B12
- Applications
- WB, ELISA
- Related Disease
- Alzheimer's Disease
Applications
- Application Notes
- The APP antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1185z | Mouse Anti-APP Recombinant Antibody (clone 25F3) | WB, FC, ICC, IF, IHC | Mouse IgG1 |
| HPAB-0970-FY | Mouse Anti-APP Recombinant Antibody (HPAB-0970-FY) | ELISA | Mouse IgG |
| HPAB-0971-FY | Mouse Anti-APP Recombinant Antibody (HPAB-0971-FY) | ELISA | Mouse IgG |
| HPAB-0973-FY | Human Anti-APP Recombinant Antibody (clone E12) | ELISA | Humanized IgG |
| HPAB-0974-FY | Human Anti-APP Recombinant Antibody (clone 1C10) | ELISA | Humanized IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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