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    Anti-Human APP Recombinant Antibody (2B12) (CAT#: TAB-0848CLV)

    The anti-APP antibody 2B12 specifically binds amyloid precursor protein from which the β-amyloid is cleaved. By binding the APP and therefore reducing the accumulation or the release of β-amyloid, the antibody can be used in the treatment of conditions related with elevated levels of β-amyloid, such as Alzheimer's Disease.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Published Data
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    WB

    Figure 1 Representative western blot of sAPPa incubated with or without BACE1 and 2B12, 2B3, control IgG, anti-N terminal APP IgG.

    Figure 1 Representative western blot of sAPPa incubated with or without BACE1 and 2B12, 2B3, control IgG, anti-N terminal APP IgG.

    Only 2B12 and 2B3 inhibited the action of BACE1 in this system.

    Thomas, R. S., Liddell, J. E., & Kidd, E. J. (2011). Anti‐amyloid precursor protein immunoglobulins inhibit amyloid‐β production by steric hindrance. The FEBS journal, 278(1), 167-178.

    ELISA

    Figure 2 Levels of intracellular APP as determined by ELISA.

    Figure 2 Levels of intracellular APP as determined by ELISA.

    After incubation with 2B3, 2B12, an anti-N-terminal APP IgG (N, MTS only) or a control irrelevant mouse IgG, all at 10 lgÆmL)1 for 48 h.

    Thomas, R. S., Liddell, J. E., & Kidd, E. J. (2011). Anti‐amyloid precursor protein immunoglobulins inhibit amyloid‐β production by steric hindrance. The FEBS journal, 278(1), 167-178.


    Specifications

    • Immunogen
    • Ka (spanning the β-secretase cleavage site in human APP)
    • Host Species
    • Mouse
    • Specificity
    • Human
    • Clone
    • 2B12
    • Applications
    • WB, ELISA
    • Related Disease
    • Alzheimer's Disease

    Applications

    • Application Notes
    • The APP antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay.

    Target

    • Alternative Names
    • APP; Amyloid Beta; amyloid beta (A4) precursor protein

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

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    CAT Product Name Application Type
    NABG-016 Recombinant Anti-Human APP VHH Single Domain Antibody CA, IP, IF, FuncS Llama VHH
    TAB-0019CL-VHH Camelid Anti-APP Recombinant Antibody (TAB-0019CL-VHH) IHC, WB Camelid VHH
    TAB-0020CL-VHH Anti-Human APP VHH Single Domain Antibody (TAB-0020CL-VHH) ELISA, IHC Single domain antibody
    TAB-0021CL-VHH Anti-Human APP VHH Single Domain Antibody (TAB-0021CL-VHH) ELISA, In vivo, FuncS Single domain antibody
    TAB-0022CL-VHH Anti-Human APP VHH Single Domain Antibody (TAB-0022CL-VHH) ELISA, In vivo, FuncS Single domain antibody

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