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    Anti-Human APP Recombinant Antibody Fab Fragment (2B12) (CAT#: TAB-0848CLV-F(E))

    The anti-APP antibody specifically binds amyloid precursor protein from which the β-amyloid is cleaved. By binding the APP and therefore reducing the accumulation or the release of β-amyloid, the antibody can be used in the treatment of conditions related with elevated levels of β-amyloid, such as Alzheimer's Disease.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-2 OS
    Figure 1 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/if_selected.jpg
    Figure 2 IF staining of human cell line A-431
    Figure 2 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/60_E2_1_blue_red_green.jpg
    Figure 3 IF staining of human cell line U-251 MG
    Figure 3 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/61_E2_1_blue_red_green.jpg
    Normal Tissue
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Neuronal cells
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/157/2073_B_7_5.jpg
    RNA Expression
    Figure 5 RNA cell line category: Low cell line specificity
    Figure 5 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP
    Figure 5 RNA cell line category: Low cell line specificity
    Figure 5 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP

    Specifications

    • Immunogen
    • Ka (spanning the β-secretase cleavage site in human APP)
    • Host Species
    • Mouse
    • Specificity
    • Human
    • Clone
    • 2B12
    • Related Disease
    • Alzheimer's Disease

    Target

    • Alternative Names
    • APP; Amyloid Beta; amyloid beta (A4) precursor protein

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

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    CAT Product Name Application Type
    MOB-1185z Mouse Anti-APP Recombinant Antibody (clone 25F3) WB, FC, ICC, IF, IHC Mouse IgG1
    PABW-009 Mouse Anti-APP Recombinant Antibody (clone PFA1) ELISA Mouse IgG2a
    PABC-010 Mouse Anti-APP Recombinant Antibody (clone PFA2) ELISA Mouse IgG2a
    MRO-1647-CN Rabbit Anti-APP Polyclonal Antibody (MRO-1647-CN) WB, IF, IHC, FC Rabbit IgG
    HPAB-0970-FY Mouse Anti-APP Recombinant Antibody (HPAB-0970-FY) ELISA Mouse IgG

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