What is the advantage of this antibody being "fully human"?

Being fully human means that the amino acid sequence of the antibody is entirely derived from human genes. In a research context, this minimizes the risk of the antibody being recognized as foreign by human immune cells in co-culture models, and it mimics the properties of a therapeutic candidate with low immunogenicity.

How does the glyco-engineering of this antibody affect its function?

The Fc region of this antibody has been glyco-engineered to enhance its effector functions. This modification typically increases binding to Fc receptors on immune cells, leading to more potent Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) against CD19-positive B cells in your experimental assays.

Anti-CD19 fully human monoclonal antibody MDX-1342

CAT#: Gly-011CL

A fully human anti-CD19 monoclonal antibody directed against the B-cell-specific membrane protein CD-19 with potential antineoplastic activity. Anti-CD19 monoclonal antibody MDX-1342 binds to CD19, depleting and eliminating CD19-expressing B-cells. CD19 is widely expressed during B-cell development, from pro-B-cell to early plasma cell stages.

Gene Expression

Normal Tissue Figure 1 Colon

Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_7_3.jpg

Normal Tissue Figure 2 Testis

Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_5_6.jpg

Normal Tissue Figure 3 Appendix

Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_2_2.jpg

Normal Tissue Figure 4 Lymph node

Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_9_8.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enhanced (Daudi, REH, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177455-CD19

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Specifications

Type
Fully human Ab

Class
Antineoplastics; Antirheumatics; Monoclonal antibodies

Mechanism of action
CD19 antigen inhibitors

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Breast cancer biomarkers at key points during disease progression

Fully Human Sequence

We selected this antibody because it is fully human, which is ideal for our research into reducing immunogenicity in therapeutic candidates. It performed exactly as expected in our binding assays, showing specific recognition of the CD19 antigen on human B cells.

Strong Effector Function

The glyco-engineering of this antibody seems to have significantly improved its effector functions. In our B cell depletion assays, it demonstrated robust activity, serving as an excellent positive control for our study on next-generation CD19 targeting agents.

Q&As

What is the advantage of this antibody being "fully human"?

A: Being fully human means that the amino acid sequence of the antibody is entirely derived from human genes. In a research context, this minimizes the risk of the antibody being recognized as foreign by human immune cells in co-culture models, and it mimics the properties of a therapeutic candidate with low immunogenicity.
How does the glyco-engineering of this antibody affect its function?

A: The Fc region of this antibody has been glyco-engineered to enhance its effector functions. This modification typically increases binding to Fc receptors on immune cells, leading to more potent Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) against CD19-positive B cells in your experimental assays.

View the frequently asked questions answered by Creative Biolabs Support.

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Related Diseases

Primary Immunodeficiency

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - Gly-011CL.pdf

MSDS

MSDS - Gly-011CL.pdf

COA

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