Anti-CD19 fully human monoclonal antibody MDX-1342 (CAT#: Gly-011CL)
A fully human anti-CD19 monoclonal antibody directed against the B-cell-specific membrane protein CD-19 with potential antineoplastic activity. Anti-CD19 monoclonal antibody MDX-1342 binds to CD19, depleting and eliminating CD19-expressing B-cells. CD19 is widely expressed during B-cell development, from pro-B-cell to early plasma cell stages.
Specific Inquiry
Normal Tissue
Figure 1 Colon
(Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_7_3.jpg
(Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_7_3.jpg
Figure 2 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_5_6.jpg
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_5_6.jpg
Figure 3 Appendix
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_2_2.jpg
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_2_2.jpg
Figure 4 Lymph node
(Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_9_8.jpg
(Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Daudi, REH, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177455-CD19
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177455-CD19
Specifications
- Type
- Fully human Ab
- Class
- Antineoplastics; Antirheumatics; Monoclonal antibodies
- Mechanism of action
- CD19 antigen inhibitors
Related Resources
Primary Immunodeficiency
Downloads
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See other products for "CD19"
Recombinant Antibody
| CAT | Product Name | Application | Type |
| MOB-1087z | Mouse Anti-CD19 Recombinant Antibody (clone 32B9) | WB, FC, ICC, IF, FuncS | Mouse IgG1 |
| HPAB-0458LY | Human Anti-CD19 Recombinant Antibody (clone CBL001LY) | FC | Human IgG1 |
| HPAB-0459LY | Human Anti-CD19 Recombinant Antibody (clone 1) | ELISA | Humanized IgG1 |
| HPAB-0460LY | Human Anti-CD19 Recombinant Antibody (clone 2) | ELISA | Humanized IgG1 |
| HPAB-0461LY | Human Anti-CD19 Recombinant Antibody (clone 3) | ELISA | Humanized IgG1 |
Humanized Antibody
| CAT | Product Name | Application | Type |
| TAB-H17 | Anti-Human CD19 Recombinant Antibody (Denintuzumab Mafodotin) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
| TAB-891 | Humanized Anti-CD19 Recombinant Antibody (clone Denintuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | Humanized IgG1, κ |
| TAB-1625CL | Anti-Human CD19 Recombinant Antibody (396) | Depletion, ELISA | Humanized antibody |
| TAB-1625CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (396) | Depletion, ELISA | Humanized antibody |
| TAB-431CQ | Anti-Human CD19 Recombinant Antibody | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
Immunotoxin
| CAT | Product Name | Application | Type |
| AGTO-L047E | anti-CD19 immunotoxin HD37 (scFv)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L047D | anti-CD19 immunotoxin HD37 (scFv)-DT | Cytotoxicity assay, Functional assay | |
| AGTO-L047R | anti-CD19 immunotoxin HD37 (scFv)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L047S | anti-CD19 immunotoxin HD37 (scFv)-Sap | Cytotoxicity assay, Functional assay | |
| AGTO-L047P | anti-CD19 immunotoxin HD37 (scFv)-PAP | Cytotoxicity assay, Functional assay |
Mouse Antibody
| CAT | Product Name | Application | Type |
| TAB-1611CL | Mouse Anti-CD19 Recombinant Antibody (TAB-1611CL) | Depletion, FuncS | Mouse IgG2a, κ |
| TAB-1620CL | Anti-Human CD19 Recombinant Antibody (HD37) | FuncS | |
| TAB-1622CL | Mouse Anti-CD19 Recombinant Antibody (TAB-1622CL) | ELISA, FC, Apop, ADCC, FuncS | Mouse IgG |
| TAB-1623CL | Mouse Anti-CD19 Recombinant Antibody (TAB-1623CL) | ELISA, FC | Mouse IgG |
| TAB-1624CL | Anti-Human CD19 Recombinant Antibody (381) | FC, Inhib, ELISA |
Chimeric Antibody
| CAT | Product Name | Application | Type |
| TAB-1613CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1613CL-S(P)) | Depletion, FuncS | Mouse scFv |
| TAB-1621CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (cHD37) | FuncS | Chimeric antibody (mouse/human) |
| TAB-1613CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1613CL-F(E)) | Depletion, FuncS | Chimeric (mouse/human) Fab |
| TAB-1614CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1614CL-F(E)) | FuncS | Chimeric (mouse/human) Fab |
| TAB-1621CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (cHD37) | FuncS | Chimeric antibody (mouse/human) |
Human Antibody
| CAT | Product Name | Application | Type |
| TAB-1616CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1616CL-F(E)) | ELISA, WB | Human Fab |
| TAB-1617CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1617CL-F(E)) | ELISA, WB | Human Fab |
| TAB-1618CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1618CL-F(E)) | ELISA, WB | Human Fab |
| TAB-1626CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (HB12a) | Depletion | Fully human antibody |
| TAB-1627CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (HB12b) | Depletion | Fully human antibody |
Fc Glycosylation
| CAT | Product Name | Application | Type |
| Gly-061LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Low fucosylated) | ELISA, FC | Chimeric antibody (mouse/human) |
| Gly-105LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation) | ELISA | Mouse antibody |
| Gly-141LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Low- or Non-fucosylated Oligosaccharide
| CAT | Product Name | Application | Type |
| Gly-061LC-1 | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Low fucosylated) | ELISA, FC | Chimeric antibody (mouse/human) |
| Gly-141LC-1 | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
| BRD-0100MZ | Chicken Anti-CD19 Polyclonal IgY | WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
| NEUT-286CQ | Mouse Anti-CD19 Recombinant Antibody (clone SJ25-C1) | Neut, FC, IHC, IHC-Fr, IP | Mouse IgG1 |
| NEUT-287CQ | Mouse Anti-CD19 Recombinant Antibody (clone HIB19) | FC, CyTOF, IHC, Block | Mouse IgG1, κ |
Blocking Antibody
| CAT | Product Name | Application | Type |
| NEUT-288CQ | Rat Anti-CD19 Recombinant Antibody (clone 1D3) | Depletion, Block, FC | Rat IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
| MOR-0538 | Hi-Affi™ Rabbit Anti-CD19 Recombinant Antibody (clone DS538AB) | IHC-P | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
| HPAB-0264-CN-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0264-CN-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0265-CN-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0265-CN-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0266-CN-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0266-CN-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0267-CN-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0267-CN-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0268-CN-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0268-CN-F(E)) | ELISA, FC | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
| HPAB-0217-FY-S(P) | Human Anti-CD19 Recombinant Antibody (clone 4); scFv Fragment | ELISA | Humanized scFv |
| HPAB-616-FY-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-616-FY-S(P)) | ELISA | Human scFv |
| HPAB-0361-FY-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0361-FY-S(P)) | FC | Mouse scFv |
| HPAB-0362-FY-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0362-FY-S(P)) | FC | Mouse scFv |
| HPAB-0363-FY-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0363-FY-S(P)) | ELISA | Human scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
| AFC-TAB-174 | Afuco™ Anti-CD19 ADCC Recombinant Antibody (Taplitumomab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
WBWestern Blot
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