Anti-Human CD19 Recombinant Antibody (HD37) (CAT#: TAB-1620CL)
This antibody that can binds to human CD19 is useful in the treatment of diseases and disorders, particularly B cell malignancies including acute lymphoblastic leukemia, hairy cell leukemia, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma.
Specific Inquiry
FuncS
Figure 1 A. Inhibition of B cell proliferation by CD19 mAb HD37.
Graded doses of antibody were added to B cells cultivated with anti-μ and BCGF. Mean proliferation ± SE of quadruplicates [three experiments] measured on day 3. B. Comparison of the inhibitory effect of whole (●-●) vs F(ab') (○-○) HD37 mAb. B cells were stimulated with anti μ + RCCF. One of three experiments.
Pezzutto, A., Dörken, B., Rabinovitch, P. S., Ledbetter, J. A., Moldenhauer, G., & Clark, E. A. (1987). CD19 monoclonal antibody HD37 inhibits anti-immunoglobulin-induced B cell activation and proliferation. The Journal of Immunology, 138(9), 2793-2799.
FuncS
Figure 2 Effect of addition of a cross-linking second antibody on CD19-induced inhibition of B cell proliferation.
Cells were cultured with anti-μ + BCGF in the presence of graded doses of HD37 mAb (●-●). Rat anti-mouse κ-Chain mAb was added at 50 μg/ml (■-■). The mean experiments. proliferation ± SE of quadruplicate cultures is shown. One of three experiments.
Pezzutto, A., Dörken, B., Rabinovitch, P. S., Ledbetter, J. A., Moldenhauer, G., & Clark, E. A. (1987). CD19 monoclonal antibody HD37 inhibits anti-immunoglobulin-induced B cell activation and proliferation. The Journal of Immunology, 138(9), 2793-2799.
Specifications
- Host Species
- Mouse
- Specificity
- Human
- Clone
- HD37
- Applications
- FuncS
- Related Disease
- B cell malignancies including acute lymphoblastic leukemia, hairy cell leukemia, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma
Applications
- Application Notes
- This antibody has been tested for use in Functional Assay.
Target
- Alternative Names
- CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4
- Gene ID
- 930
- UniProt ID
- P15391
Related Resources
Primary Immunodeficiency
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1087z | Mouse Anti-CD19 Recombinant Antibody (clone 32B9) | WB, FC, ICC, IF, FuncS | Mouse IgG1 |
| HPAB-0264-CN | Human Anti-CD19 Recombinant Antibody (HPAB-0264-CN) | ELISA, FC | Humanized IgG1, κ |
| HPAB-0265-CN | Human Anti-CD19 Recombinant Antibody (HPAB-0265-CN) | ELISA, FC | Humanized IgG1, κ |
| HPAB-0266-CN | Human Anti-CD19 Recombinant Antibody (HPAB-0266-CN) | ELISA, FC | Humanized IgG |
| HPAB-0267-CN | Human Anti-CD19 Recombinant Antibody (HPAB-0267-CN) | ELISA, FC | Humanized IgG |
Customer Reviews and Q&As
Customer Review
Q&As
-
Reliable for Cell Sorting
The HD37 antibody worked exceptionally well in our flow cytometry assays. We were able to isolate a high percentage of CD19-positive B-cells with minimal background noise, making our subsequent analyses much more reliable. -
Great for Differentiation Studies
Using the HD37 antibody, we could effectively map the stages of B-cell differentiation in our samples. It provided clear, consistent results that were invaluable for our immunological research. -
High-Quality Antibody
The HD37 antibody maintained its stability even after several freeze-thaw cycles. Its high-quality preparation ensures that our flow cytometry and sorting experiments are always reproducible.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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