Anti-Human CD19 Recombinant Antibody (HD37)
CAT#: TAB-1620CL
This antibody that can binds to human CD19 is useful in the treatment of diseases and disorders, particularly B cell malignancies including acute lymphoblastic leukemia, hairy cell leukemia, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma.
Published Data
Gene Expression
FuncS
Figure 1 A. Inhibition of B cell proliferation by CD19 mAb HD37.
Graded doses of antibody were added to B cells cultivated with anti-μ and BCGF. Mean proliferation ± SE of quadruplicates [three experiments] measured on day 3. B. Comparison of the inhibitory effect of whole (●-●) vs F(ab') (○-○) HD37 mAb. B cells were stimulated with anti μ + RCCF. One of three experiments.
Pezzutto, A., Dörken, B., Rabinovitch, P. S., Ledbetter, J. A., Moldenhauer, G., & Clark, E. A. (1987). CD19 monoclonal antibody HD37 inhibits anti-immunoglobulin-induced B cell activation and proliferation. The Journal of Immunology, 138(9), 2793-2799.
FuncS
Figure 2 Effect of addition of a cross-linking second antibody on CD19-induced inhibition of B cell proliferation.
Cells were cultured with anti-μ + BCGF in the presence of graded doses of HD37 mAb (●-●). Rat anti-mouse κ-Chain mAb was added at 50 μg/ml (■-■). The mean experiments. proliferation ± SE of quadruplicate cultures is shown. One of three experiments.
Pezzutto, A., Dörken, B., Rabinovitch, P. S., Ledbetter, J. A., Moldenhauer, G., & Clark, E. A. (1987). CD19 monoclonal antibody HD37 inhibits anti-immunoglobulin-induced B cell activation and proliferation. The Journal of Immunology, 138(9), 2793-2799.
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Normal Tissue
Figure 1 Colon
Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_7_3.jpg
Normal Tissue
Figure 2 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_5_6.jpg
Normal Tissue
Figure 3 Appendix
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_2_2.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Daudi, REH, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177455-CD19
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Specifications
- Host Species
- Mouse
- Specificity
- Human
- Clone
- HD37
- Applications
- FuncS
- Related Disease
- B cell malignancies including acute lymphoblastic leukemia, hairy cell leukemia, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma
Applications
- Application Notes
- This antibody has been tested for use in Functional Assay.
Target
REVIEWS AND Q&AS
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Reliable for Cell Sorting
The HD37 antibody worked exceptionally well in our flow cytometry assays. We were able to isolate a high percentage of CD19-positive B-cells with minimal background noise, making our subsequent analyses much more reliable.
Great for Differentiation Studies
Using the HD37 antibody, we could effectively map the stages of B-cell differentiation in our samples. It provided clear, consistent results that were invaluable for our immunological research.
High-Quality Antibody
The HD37 antibody maintained its stability even after several freeze-thaw cycles. Its high-quality preparation ensures that our flow cytometry and sorting experiments are always reproducible.
Q&As
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Can the steps of B-cell development be studied using the Anti-Human CD19 Recombinant Antibody (HD37)?
A: Yes, the HD37 antibody is very well-suited for studying B-cell differentiation. By employing this antibody in immunophenotyping, researchers can track the expression of CD19 at various stages of B-cell development. This makes it easier to understand the differentiation pathways and identify any anomalies in B-cell maturation.
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In what ways does the HD37 antibody help with CD19-positive cell enrichment for subsequent functional assays?
A: The HD37 antibody can be conjugated to magnetic beads or fluorescent markers, allowing for the efficient separation of CD19-positive cells via magnetic-activated cell sorting (MACS) or flow cytometry. This strategy ensures that a highly purified population of B-cells is obtained, which can be used for subsequent in vitro functional assays or gene expression analyses.
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Is it possible to modify the Anti-Human CD19 Recombinant Antibody (HD37) to improve its effector activities or specificity?
A: Yes, the HD37 antibody can be modified to enhance its binding affinity, specificity, or effector functions such as antibody-dependent cellular cytotoxicity (ADCC). These engineered versions can be tailored for specific research needs or therapeutic applications, making them versatile tools in both lab and clinical settings.
View the frequently asked questions answered by Creative Biolabs Support.
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Related Diseases
Primary Immunodeficiency
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
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|---|---|---|---|
| AGTO-G076E | Anti-CD19 immunotoxin HD37 (IgG)-PE | Cytotoxicity assay, Function study | |
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| CAT | Product Name | Application | Type |
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| TAB-1612CL | Human Anti-CD19 Recombinant Antibody (TAB-1612CL) | Depletion, FuncS | Humanized IgG1 |
| TAB-1612CL-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1612CL-S(P)) | Depletion, FuncS | Humanized scFv |
| TAB-1625CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (396) | Depletion, ELISA | Humanized antibody |
| TAB-1612CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1612CL-F(E)) | Depletion, FuncS | Humanized Fab |
| TAB-1625CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (396) | Depletion, ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1613CL | Human Anti-CD19 Recombinant Antibody (TAB-1613CL) | Cyt, FC, FuncS, Inhib | Chimeric (mouse/human) IgG1 |
| TAB-1614CL | Human Anti-CD19 Recombinant Antibody (TAB-1614CL) | FuncS | Chimeric (mouse/human) IgG |
| TAB-1613CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1613CL-S(P)) | Depletion, FuncS | Mouse scFv |
| TAB-1614CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1614CL-S(P)) | FuncS | Mouse scFv |
| TAB-1621CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (cHD37) | FuncS | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1611CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1611CL-S(P)) | Depletion, FuncS | Mouse scFv |
| TAB-1620CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (HD37) | FuncS | |
| TAB-1622CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1622CL-S(P)) | ELISA, FC, Apop, ADCC, FuncS | Mouse scFv |
| TAB-1623CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1623CL-S(P)) | ELISA, FC | Mouse scFv |
| TAB-1624CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (381) | FC, Inhib, ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1616CL-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1616CL-S(P)) | ELISA, WB | Human scFv |
| TAB-1617CL-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1617CL-S(P)) | ELISA, WB | Human scFv |
| TAB-1618CL-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1618CL-S(P)) | ELISA, WB | Human scFv |
| TAB-1619CL-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1619CL-S(P)) | ELISA, WB | Human scFv |
| TAB-1626CL-S(P) | Human Anti-CD19 Recombinant Antibody scFv Fragment (TAB-1626CL-S(P)) | Depletion | Fully human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-061LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Low fucosylated) | ELISA, FC | Chimeric antibody (mouse/human) |
| Gly-105LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation) | ELISA | Mouse antibody |
| Gly-141LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-061LC-1 | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Low fucosylated) | ELISA, FC | Chimeric antibody (mouse/human) |
| Gly-141LC-1 | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0100MZ | Chicken Anti-CD19 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-286CQ | Mouse Anti-CD19 Recombinant Antibody (clone SJ25-C1) | Neut, FC, IHC, IHC-Fr, IP | Mouse IgG1 |
| NEUT-287CQ | Mouse Anti-CD19 Recombinant Antibody (clone HIB19) | FC, CyTOF, IHC, Block | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-288CQ | Rat Anti-CD19 Recombinant Antibody (clone 1D3) | Depletion, Block, FC | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0538 | Hi-Affi™ Rabbit Anti-CD19 Recombinant Antibody (clone DS538AB) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0696LY | Mouse Anti-CD19 Recombinant Antibody (clone PGC3D6H10) | ELISA, WB, FC, IF | Mouse IgG |
| HPAB-2977LY | Human Anti-CD19 Recombinant Antibody (clone 1F1) | ELISA, FC | Human IgG |
| HPAB-2978LY | Human Anti-CD19 Recombinant Antibody (clone 1H11) | ELISA, FC | Human IgG |
| HPAB-0361-FY | Mouse Anti-CD19 Recombinant Antibody (HPAB-0361-FY) | FC | Mouse IgG2a |
| HPAB-0362-FY | Mouse Anti-CD19 Recombinant Antibody (HPAB-0362-FY) | FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0418LY-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0418LY-S(P)) | ELISA, WB, FC, RIA | Human scfv |
| HPAB-0419LY-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0419LY-S(P)) | ELISA, WB, FC, RIA | Human scfv |
| HPAB-0420LY-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0420LY-S(P)) | ELISA, WB, FC, RIA | Human scfv |
| HPAB-0421LY-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0421LY-S(P)) | ELISA, WB, FC, RIA | Human scfv |
| HPAB-0422LY-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0422LY-S(P)) | ELISA, WB, FC, RIA | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-616-FY-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-616-FY-F(E)) | ELISA | Human Fab |
| HPAB-3158LY-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-3158LY-F(E)) | ELISA | Mouse Fab |
| HPAB-3159LY-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-3159LY-F(E)) | ELISA | Mouse Fab |
| HPAB-3160LY-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-3160LY-F(E)) | ELISA | Mouse Fab |
| HPAB-3161LY-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-3161LY-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
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| AFC-TAB-174 | Afuco™ Anti-CD19 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-174) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
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| VS-0724-YC640 | AbPlus™ Anti-CD19 Magnetic Beads (VS-0724-YC640) | IP, Protein Purification |
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| VS-1024-XY83 | Mouse Anti-NHP CD19 Recombinant Antibody (clone PDR134) | WB, IF, FC | Mouse IgM, kappa |
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| VS-0225-XY20 | CytoStream™ Mouse Anti-CD19 Recombinant Antibody (VS-0225-XY20) | FC | Mouse IgG1, kappa |
| VS13-YC154 | CytoStream™ Rabbit Anti-CD19 Recombinant Antibody (VS13-YC154) | WB, ICC, IF, IHC-P, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| VS-0325-FY59 | Human Anti-CD19 (clone 2A3) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
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| VS-0425-YC75 | Recombinant Anti-CD19 Vesicular Antibody, EV Displayed (VS-0425-YC75) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
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| VS-0525-XY1127 | Anti-Rat CD19 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1128 | Anti-Mouse CD19 Immunohistochemistry Kit | IHC |
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