Anti-Human CD19 Recombinant Antibody (HD37) (CAT#: TAB-1620CL)
This antibody that can binds to human CD19 is useful in the treatment of diseases and disorders, particularly B cell malignancies including acute lymphoblastic leukemia, hairy cell leukemia, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma.
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We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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FuncS
Figure 1 A. Inhibition of B cell proliferation by CD19 mAb HD37.
Graded doses of antibody were added to B cells cultivated with anti-μ and BCGF. Mean proliferation ± SE of quadruplicates [three experiments] measured on day 3. B. Comparison of the inhibitory effect of whole (●-●) vs F(ab') (○-○) HD37 mAb. B cells were stimulated with anti μ + RCCF. One of three experiments.
Pezzutto, A., Dörken, B., Rabinovitch, P. S., Ledbetter, J. A., Moldenhauer, G., & Clark, E. A. (1987). CD19 monoclonal antibody HD37 inhibits anti-immunoglobulin-induced B cell activation and proliferation. The Journal of Immunology, 138(9), 2793-2799.
FuncS
Figure 2 Effect of addition of a cross-linking second antibody on CD19-induced inhibition of B cell proliferation.
Cells were cultured with anti-μ + BCGF in the presence of graded doses of HD37 mAb (●-●). Rat anti-mouse κ-Chain mAb was added at 50 μg/ml (■-■). The mean experiments. proliferation ± SE of quadruplicate cultures is shown. One of three experiments.
Pezzutto, A., Dörken, B., Rabinovitch, P. S., Ledbetter, J. A., Moldenhauer, G., & Clark, E. A. (1987). CD19 monoclonal antibody HD37 inhibits anti-immunoglobulin-induced B cell activation and proliferation. The Journal of Immunology, 138(9), 2793-2799.
Specifications
- Host Species
- Mouse
- Specificity
- Human
- Clone
- HD37
- Applications
- FuncS
- Related Disease
- B cell malignancies including acute lymphoblastic leukemia, hairy cell leukemia, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma
Applications
- Application Notes
- This antibody has been tested for use in Functional Assay.
Target
- Alternative Names
- CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4
- Gene ID
- 930
- UniProt ID
- P15391
Related Resources
Primary Immunodeficiency
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H17 | Anti-Human CD19 Recombinant Antibody (TAB-H17) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
| TAB-891 | Humanized Anti-CD19 Recombinant Antibody (TAB-891) | ELISA, FC, IP, FuncS, IF, Neut, ICC | Humanized IgG1, κ |
| TAB-1612CL | Human Anti-CD19 Recombinant Antibody (TAB-1612CL) | Depletion, FuncS | Humanized IgG1 |
| TAB-1625CL | Anti-Human CD19 Recombinant Antibody (396) | Depletion, ELISA | Humanized antibody |
| TAB-431CQ | Anti-Human CD19 Recombinant Antibody | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
Customer Reviews and Q&As
Customer Review
Q&As
Reliable for Cell Sorting
The HD37 antibody worked exceptionally well in our flow cytometry assays. We were able to isolate a high percentage of CD19-positive B-cells with minimal background noise, making our subsequent analyses much more reliable.
Great for Differentiation Studies
Using the HD37 antibody, we could effectively map the stages of B-cell differentiation in our samples. It provided clear, consistent results that were invaluable for our immunological research.
High-Quality Antibody
The HD37 antibody maintained its stability even after several freeze-thaw cycles. Its high-quality preparation ensures that our flow cytometry and sorting experiments are always reproducible.
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For Research Use Only. Not For Clinical Use.
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