Recombinant Anti-CD19 Vesicular Antibody, EV Displayed (VS-0425-YC75)

Name: Recombinant Anti-CD19 Vesicular Antibody, EV Displayed (VS-0425-YC75)
SKU: VS-0425-YC75
Rating: 5 (1 reviews)

CAT#: VS-0425-YC75

The Recombinant Anti-CD19 Vesicular Antibody, EV Displayed (VS-0425-YC75) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CD19-expressed cells or tissues. The CD19 is a protein essential for B-cell activation and immune response, associated with variable immunodeficiency.

Gene Expression

Normal Tissue Figure 1 Colon

Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_7_3.jpg

Normal Tissue Figure 2 Testis

Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_5_6.jpg

Normal Tissue Figure 3 Appendix

Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_2_2.jpg

Normal Tissue Figure 4 Lymph node

Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_9_8.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enhanced (Daudi, REH, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177455-CD19

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Recombinant Antibody

Application
ELISA, FC, Neut, Cell-uptake

Product Type
Ab-Fc-EVs

Antibody Quantification (Ab/EV)
~100 Ab/EV

Target
CD19

Host Animal
Human

Antibody Isotype
IgG

Species Reactivity
Human

Expression Cell
Mammalian cell

Engineered EVs

EV-sorting domain
CD63

Fc-binding domain
z domain

EV Size
30~150 nm

Producing Cell
HEK293F

Isolation Method
Gradient centrifugation

Purification
qEV size exclusion chromatography

Binding Affinity
Kd = 0.85 µg/mL

Concentration
1 x 10¹⁰

Size
1 mL

Buffer
PBS

Storage
Store at -80°C for 12 months

Target

Full Name
CD19 molecule

Biological Process
Adaptive immunity, Immunity

Introduction
CD19 (CD19 Molecule) is a Protein Coding gene. Diseases associated with CD19 include Immunodeficiency, Common Variable, 3 and Common Variable Immunodeficiency. Among its related pathways are RET signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include signal transducer activity, downstream of receptor.

Gene ID
930

UniProt ID
P15391

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Related Diseases

Primary Immunodeficiency

Downloadable Resources

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Datasheet

Datasheet - VS-0425-YC75.pdf

MSDS

MSDS - VS-0425-YC75.pdf

COA

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