Recombinant Humanized monoclonal antibody expressed in CHO binding to Human CD40. APX005 is a promising immunotherapeutic capable of destroying tumor and tumor stroma through several distinct mechanisms of action. APX005 is a strong CD40 agonist that can stimulate anti-tumor immune responses by binding to CD40 molecules on the antigen presenting cells and activating immune co-stimulatory pathways to boost tumor-specific immunity. Furthermore, APX005 can also trigger direct tumor killing.
Figure 1 is a graph shows the results of an ELISA assay demonstrating that APX005 blocks the binding of CD40L to CD40.
Figure 3 shows in vitro inhibition of Ramos tumor cell proliferation by APX005.
Panel A: without Fc crosslinking; Panel B: with Fc crosslinking.
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For Research Use Only. Not For Clinical Use.