Anti-Human CD44 Recombinant Antibody (RG7356) (CAT#: TAB-128CL)
Recombinant Humanized monoclonal antibody expressed in CHO binding to Human CD44. RG7356 is a humanized antibody targeting the constant region of CD44 that shows antitumor efficacy in mice implanted with CD44-expressing tumors such as MDA-MB-231 breast cancer cells. Short-term treatment of tumor-bearing mice with RG7356 resulted in modifications of the MAPK pathway in the responsive model, although no effects on downstream phosphorylation were observed in a nonresponsive xenograft model.
Specific Inquiry
Figure 1 RG7356 serum concentration versus time plot in patients in Arm A who received the biweekly (q2w) (A) and weekly (qw) (B) dosing schedules.
Menke-van der Houven, C. W., van Oordt, C. G. R., van Herpen, C., Coveler, A. L., Mahalingam, D., Verheul, H. M.,... & Cannarile, M. A. (2016). First-in-human phase I clinical trial of RG7356, an anti-CD44 humanized antibody, in patients with advanced, CD44-expressing solid tumors. Oncotarget, 7(48), 80046.
Specifications
- Derivation
- Humanized
- Type
- Antibody
- Species Reactivity
- Human
- Related Disease
- Chronic Lymphocytic Leukemia; Solid Tumors
Product Property
- Purity
- >98% by SDS-PAGE and HPLC analysis
- Storage
- 4°C or -20°C, avoid repeated freezing and thawing.
Target
- Alternative Names
- CD44; CD44 molecule (Indian blood group); IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; CD44 antigen; epican; Hermes antigen; hyaluronate receptor; phagocytic glycoprotein 1; heparan sulfate proteoglycan; cell surface glyc
- Gene ID
- 960
- UniProt ID
- P16070
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CD44"
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-727 | Anti-CD44 Recombinant Antibody (Bivatuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 |
| TAB-236LC | Anti-Human CD44 Recombinant Antibody (huPTA-4621) | FuncS | Humanized antibody |
| TAB-236LC-S(P) | Anti-Human CD44 Recombinant Antibody scFv Fragment (huPTA-4621) | FC | Humanized antibody |
| TAB-236LC-F(E) | Anti-Human CD44 Recombinant Antibody Fab Fragment (huPTA-4621) | FC | Humanized antibody |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-231LC | Human Anti-CD44 Recombinant Antibody (TAB-231LC) | ELISA | Chimeric antibody (mouse/human) |
| TAB-232LC | Human Anti-CD44 Recombinant Antibody (TAB-232LC) | ELISA | Chimeric antibody (mouse/human) |
| TAB-235LC | Anti-Human CD44 Recombinant Antibody (chPTA-4621) | FuncS | Chimeric antibody (mouse/human) |
| TAB-231LC-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (TAB-231LC-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| TAB-232LC-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (TAB-232LC-F(E)) | ELISA | Chimeric (mouse/human) Fab |
Mouse Antibody
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-239LC | Human Anti-CD44 Recombinant Antibody (TAB-239LC) | FC | Human IgG |
| TAB-239LC-S(P) | Human Anti-CD44 Recombinant Antibody; scFv Fragment (TAB-239LC-S(P)) | FC | Human scFv |
| TAB-226LC-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (TAB-226LC-F(E)) | WB, ELISA | Human Fab |
| TAB-227LC-F(E) | Anti-Human CD44 Recombinant Antibody Fab Fragment (1A9.A6.B9) | FC, ELISA | Human antibody |
| TAB-239LC-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (TAB-239LC-F(E)) | FC | Human Fab |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0101MZ | Chicken Anti-CD44 Polyclonal IgY | WB | Chicken antibody |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-378CQ | Rat Anti-CD44 Recombinant Antibody (clone 1M7.8.1) | FC, IF, Inhib, IP, WB | Rat IgG2b |
| NEUT-381CQ | Human Anti-CD44 Recombinant Antibody (clone Hermes-3) | ELISA, FC, IF, IHC, IP, Neut, WB | Human IgG1, κ |
| NEUT-382CQ | Rat Anti-CD44 Recombinant Antibody (clone IM7) | Block | Rat IgG2b |
| NEUT-383CQ | Rat Anti-CD44 Recombinant Antibody (clone KM201), FITC | Block, FC, IP, WB, FuncS | Rat IgG1, κ |
| NEUT-384CQ | Rat Anti-CD44 Recombinant Antibody (clone KM81) | IF, IHC-P, FC, Block | Rat IgG2a |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-379CQ | Mouse Anti-CD44 Recombinant Antibody (clone F10-44-2) | WB, Neut, FC, IHC, IHC-Fr, IHC-P, IP, ICC | Mouse IgG2a |
| NEUT-380CQ | Rat Anti-CD44 Recombinant Antibody (clone Hermes-1) | WB, Neut, ELISA, FC, IF, IHC, IP | Rat IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0563 | Hi-Affi™ Rabbit Anti-CD44 Recombinant Antibody (clone DS563AB) | FC, IF, IHC-Fr, IHC-P, WB | Rabbit IgG |
| MOR-4548 | Hi-Affi™ Rabbit Anti-CD44 Recombinant Antibody (clone TH58DS) | IF, ICC, FC | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0054-YC-S(P) | Mouse Anti-CD44 Recombinant Antibody (clone mH460-16-2); scFv Fragment | ELISA, FC, IHC | Mouse scFv |
| HPAB-0055-YC-S(P) | Human Anti-CD44 Recombinant Antibody (clone chH460-16-2); scFv Fragment | ELISA, FC, IHC | Mouse scFv |
| FAMAB-0019-CN-S(P) | Mouse Anti-CD44 Recombinant Antibody (clone AV6); scFv Fragment | FC | Mouse scFv |
| HPAB-0154-FY-S(P) | Human Anti-CD44 Recombinant Antibody (clone (hu)ARH460-16-2 variant HV2/KV1); scFv Fragment | Inhib | Humanized scFv |
| HPAB-N0328-YC-S(P) | Rat Anti-CD44 Recombinant Antibody (clone 9A4); scFv Fragment | WB, ELISA, IHC-P, IHC-Fr | Rat scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0019-CN | Mouse Anti-CD44 Recombinant Antibody (clone AV6) | FC | Mouse IgG |
| HPAB-N0328-YC | Rat Anti-CD44 Recombinant Antibody (clone 9A4) | WB, ELISA, IHC-P, IHC-Fr | Rat IgG1 |
| HPAB-0746-FY | Human Anti-CD44 Recombinant Antibody (HPAB-0746-FY) | ELISA | Human IgG |
| HPAB-0747-FY | Human Anti-CD44 Recombinant Antibody (HPAB-0747-FY) | ELISA | Human IgG |
| HPAB-0563-WJ | Human Anti-CD44 Recombinant Antibody (clone 1A9) | WB | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0019-CN-F(E) | Mouse Anti-CD44 Recombinant Antibody (clone AV6); Fab Fragment | FC | Mouse Fab |
| HPAB-0563-WJ-F(E) | Human Anti-CD44 Recombinant Antibody (clone 1A9); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0564-WJ-F(E) | Human Anti-CD44 Recombinant Antibody (clone 2D1); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0565-WJ-F(E) | Human Anti-CD44 Recombinant Antibody (clone 14G9); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0566-WJ-F(E) | Human Anti-CD44 Recombinant Antibody (clone 10C8); Fab Fragment | ELISA, FC | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-727 | Afuco™ Anti-CD44 ADCC Recombinant Antibody (Bivatuzumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for TAB-128CL. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.