Anti-CD70 Antibody-Cytokine Fusion Protein, IgG-IFNγ
CAT#: ACFP-SH160
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD70 IgG to IFNγ. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD70 as well as the biological activity of IFNγ. The immunocytokine displays high levels of species-specific IFN-γ activity and selective binding to CD70 on human RCC cells. This immunocytokine was designed for treating Metastatic renal cell carcinoma.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SiHa
Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (SiHa, THP-1, U-251 MG, U-266/70, U-266/84, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
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Specifications
- Target
- CD70
- Molecule Class
- L Kappa; IgG1-IFNγ
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- c1F6
- Related Disease
- Metastatic renal cell carcinoma
- Cytokine 1
- IFNγ
- Cytokines 1 Description
- Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class ofinterferons. The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes or tuberculin-sensitized mouse peritoneal lymphocytes challenged with PPD; the resulting supernatants were shown to inhibit growth of vesicular stomatitis virus. Those reports also contained the basic observation underlying the now widely employed interferon gamma release assay used to test for tuberculosis. In humans, the IFNγ protein is encoded by the IFNG gene.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
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Datasheet
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| TAB-882 | Anti-Human CD70 Recombinant Antibody (Vorsetuzumab Mafodotin) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
| TAB-335LC-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-335LC-S(P)) | ELISA | Humanized scFv |
| TAB-342LC-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-342LC-S(P)) | FC | Humanized scFv |
| TAB-343LC-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-343LC-S(P)) | FC | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-336LC | Anti-Human CD70 Recombinant Antibody (Mb VLVH) | ELISA, FC, WB | Human antibody |
| TAB-337LC | Anti-Human CD70 Recombinant Antibody (Mb VHVL) | ELISA, FC, WB | Human antibody |
| TAB-338LC | Anti-Human CD70 Recombinant Antibody (VL-5-VH) | FC, WB | Human antibody |
| TAB-339LC | Anti-Human CD70 Recombinant Antibody (VH-5-VL) | FC, WB | Human antibody |
| TAB-340LC | Anti-Human CD70 Recombinant Antibody (VL-8-VH) | FC, WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-403CQ | Rat Anti-Cd70 Recombinant Antibody (clone 9G24) | ELISA, Neut | Rat IgG1 |
| NEUT-405CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL684) | ELISA, Neut | Rat IgG1 |
| NEUT-406CQ | Rat Anti-Cd70 Recombinant Antibody (clone FR70) | FC, FuncS, Neut, IP | Rat IgG2b, κ |
| NEUT-407CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL856) | ELISA, Neut | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-404CQ | Rat Anti-Cd70 Recombinant Antibody (clone MAB0825) | Block, FC, Inhib, IP | Rat IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0095-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0095-LSX-S(P)) | ELISA, FC | Human scFv |
| HPAB-0096-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0096-LSX-S(P)) | ELISA, FC | Human scFv |
| HPAB-0097-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0097-LSX-S(P)) | ELISA, FC | Human scFv |
| HPAB-0098-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0098-LSX-S(P)) | ELISA, FC | Human scFv |
| HPAB-0099-LSX-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0099-LSX-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H76 | Afuco™ Anti-CD70 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H76) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0468-WJ | Human Anti-CD70 Recombinant Antibody (HPAB-0468-WJ) | ELISA | Human IgG |
| HPAB-0469-WJ | Human Anti-CD70 Recombinant Antibody (HPAB-0469-WJ) | ELISA | Human IgG |
| HPAB-0470-WJ | Human Anti-CD70 Recombinant Antibody (HPAB-0470-WJ) | ELISA | Human IgG |
| HPAB-0471-WJ | Human Anti-CD70 Recombinant Antibody (HPAB-0471-WJ) | ELISA | Human IgG |
| VS-0723-WK186 | Rabbit Anti-CD70 Recombinant Antibody (VS-0723-WK186) | ELISA, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0468-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0468-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0469-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0469-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0470-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0470-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0471-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0471-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0472-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0472-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC123 | Human Anti-CD70 Recombinant Antibody Hexamer (VS-0924-YC123), CDC Enhanced | ELISA, Inhib, ADCC, ADCP, CDC | Antibody hexamer |
| VS-0924-YC124 | Mouse Anti-CD70 Recombinant Antibody Hexamer (VS-0924-YC124), CDC Enhanced | FC, ADCC, CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY69 | CytoStream™ Rat Anti-CD70 Recombinant Antibody (clone FR70) | FC, Block, IF, Inhib | Rat IgG2b, kappa |
| VS-0225-XY70 | CytoStream™ Mouse Anti-CD70 Recombinant Antibody (clone Ki-24) | FC | Mouse IgG3, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY72 | Human Anti-CD70 (clone 2H5) scFv-Fc Chimera | FC, ELISA, IHC, Block | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC77 | Recombinant Anti-CD70 Vesicular Antibody, EV Displayed (VS-0425-YC77) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1215 | Anti-CD70 Immunohistochemistry Kit | IHC |
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