Anti-CD70 (MDX-1115)-Duocarmycins ADC (MDX-1203) (CAT#: ADC-L012)
This ADC product is composed of an anti-CD70 antibody (MDX-1115) conjuagated to Duocarmycins (MDX-1115-Duocarmycins). It has demonstrated a response in NHL treatment by a MOA (Mechanism of Action) of Bind to DNA minor groove and cause DNA damage.
Specific Inquiry
Subcellular Location and Protein Expression
RNA Expression

Figure 1 IF staining of human cell line SiHa
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg

Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg

Figure 3 RNA cell line category: Cell line enhanced (SiHa, THP-1, U-251 MG, U-266/70, U-266/84, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
Specifications
- Antibody Overview
- Fully human IgG monoclonal antibody that binds to CD70
- Clone
- MDX-1115
- Antibody Conjugation
- Human
- Linker
- cleavable di-peptide linker
- Linker Class/Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- Duocarmycins
- Drug Class/Description
- Duocarmycins belong to the minor-groove-binding DNA-alkylating agents (DNA MGBA). The natural duocarmycins are isolated from the culture broth of Streptmyces sp and a series of derivatives has also been synthesized
Target
- Introduction
- The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
- Alternative Names
- CD27L; CD27LG; TNFSF7; TNLG8A
- Gene ID
- 970
- UniProt ID
- P32970
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1584z | Mouse Anti-CD70 Recombinant Antibody (clone 24B8) | FC, IF, IHC, IP | Mouse IgG1, κ |
MOB-1639MZ | Recombinant Mouse Anti-Human CD70 Antibody (clone CV70) | ELISA, FC, FuncS, IHC-Fr, IP | Mouse antibody |
HPAB-M0487-YC | Rat Anti-CD70 Recombinant Antibody (clone 4F2-12) | FC | Rat IgG2a, κ |
FN-046CQ | Mouse Anti-CD70 Recombinant Antibody (clone BU69) | ELISA, FC, Block, ICC, IHC | Mouse IgG1 |
VS1-YJ31 | Mouse Anti-CD70 Recombinant Antibody (clone BU69), FITC | IHC-Fr, FC | Mouse IgG1 |
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