Anti-CD70 (MDX-1115)-Duocarmycins ADC (MDX-1203) (CAT#: ADC-L012)

• Antibody Overview
• Fully human IgG monoclonal antibody that binds to CD70

• Clone
• MDX-1115

• Antibody Conjugation
• Human

• Linker
• cleavable di-peptide linker

• Linker Class/Description
• Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• Duocarmycins

• Drug Class/Description
• Duocarmycins belong to the minor-groove-binding DNA-alkylating agents (DNA MGBA). The natural duocarmycins are isolated from the culture broth of Streptmyces sp and a series of derivatives has also been synthesized

• Introduction
• The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

• Alternative Names
• CD27L; CD27LG; TNFSF7; TNLG8A

• Gene ID
• 970

• UniProt ID
• P32970

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