anti-CD80 immunotoxin 6G7 (IgG)-Sap
CAT#: AGTO-L001S
This immunotoxin was achieved by conjugating/fusing the anti-CD80 monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CD80-expressing cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of Hodgkin's disease or other CD80-expressing tumours.
Gene Expression
Normal Tissue
Figure 1 Bone marrow
Hematopoietic cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25368/56116_B_6_4.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25368/56076_A_9_8.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, Karpas-707, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121594-CD80
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Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- 6G7
- Molecule Class
- L kappa; IgG1-Sap
- Toxin Description
- Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Hodgkin's lymphoma
Target
- Alternative Names
- CD80; CD80 molecule; B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1; T-lymphocyte activation antigen CD80; activation B7-1 antigen; costimulatory factor CD80; CTLA-4 counter-receptor B7.1; B-lymphocyte activation antigen B7; costimulatory molecule variant IgV-CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); Hodgkin's lymphoma; lymphoma; saporin; saporin-6; saporin-S6; SAP
- Gene ID
- 941
- UniProt ID
- P01589
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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