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CD80

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CD80 (CD80 Molecule) is a Protein Coding gene. The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. CD80 is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activationand survival. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. Diseases associated with CD80 include Focal Segmental Glomerulosclerosis and Vaccinia. Among its related pathways are Akt Signaling and Rheumatoid arthritis. Galiximab is a monoclonal antibody designed for the treatment of B-cell lymphoma. As of September 2009, it is undergoing Phase III clinical trials. The drug is a chimeric antibody from Macaca irus and Homo sapiens.

Species Reactivity:
Human
Type:
ADCC enhanced antibody
Host animal:
Human
Specificity:
Human
Type:
Chimeric antibody (primate/human)
Classification:
Fc glycosylation/Non fucosylated
Glycosylation site:
Fc region
Host animal:
Human
Specificity:
Human
Type:
Chimeric antibody (primate/human)
Classification:
Fc glycosylation/Non fucosylated
Glycosylation site:
Fc region
Species Reactivity:
Human, Mouse, Rat
Type:
Chicken antibody
Application:
WB
Species Reactivity:
Human
Type:
IgG1
Application:
FC, IHC, CyTOF, ELISA(Cap), Neut
Species Reactivity:
Human
Type:
IgG1
Application:
FC, IHC, Neut, WB
Species Reactivity:
Human
Type:
IgG1
Application:
IP, Neut
Species Reactivity:
Human
Type:
IgG1
Application:
Neut, FC
Species Reactivity:
Mouse
Type:
IgG2a, κ
Application:
IP, BL
Species Reactivity:
Mouse
Type:
IgG
Application:
BL, FC, IHC-Fr
Species Reactivity:
Dog, Mouse, Pig
Type:
IgG
Application:
FC, FuncS, Neut, IHC, IHC-Fr
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Scaffold Name:
CTLA-4 (extracellular domain)
Target:
CD80
Species Reactivity:
Human
Derivation:
Phage display
Derivation:
Phage display library screening
Species Reactivity:
Human
Type:
IgG
Application:
WB, IHC
Species Reactivity:
Human
Type:
Monkey IgG
Application:
FC, ELISA
Species Reactivity:
Human
Type:
Monkey IgG
Application:
FC, ELISA
Species Reactivity:
Human
Type:
Monkey IgG
Application:
FC, ELISA
Derivation:
Chimeric (primate/human)
Species Reactivity:
Human
Type:
IgG1 - lambda
Application:
WB, ELISA, FC, IP, FuncS, IF, Neut
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