Mouse Anti-CD80 (clone AB007) scFv-Fc Chimera (CAT#: VS-0425-FY9)
CD80 plays a crucial role in modulating immune responses by delivering co-stimulatory signals to T cells. By binding to CD80, Anti-CD80 scFv-Fc can interrupt the CD28/CD80 interaction, thereby downregulating T cell activation and proliferation. This characteristic positions Anti-CD80 scFv-Fc as a potential therapeutic agent for autoimmune diseases, transplant rejection, and certain types of cancers where modulation of the immune response is beneficial.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Normal Tissue
RNA Expression
Figure 1 Bone marrow
(Hematopoietic cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25368/56116_B_6_4.jpg
(Hematopoietic cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25368/56116_B_6_4.jpg
Figure 2 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25368/56076_A_9_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25368/56076_A_9_8.jpg
Figure 3 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, Karpas-707, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121594-CD80
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121594-CD80
Figure 3 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, Karpas-707, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121594-CD80
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121594-CD80
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human CD80
- Species Reactivity
- Human
- Clone
- AB007
- Applications
- Immunoassay
- Related Disease
- Focal Segmental Glomerulosclerosis and Vaccinia
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- CD80 Molecule; CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen); B-Lymphocyte Activation Antigen B7; CTLA-4 Counter-Receptor B7.1; Activation B7-1 Antigen; CD28LG1; CD28LG; LAB7; BB1
- Gene ID
- 941
- UniProt ID
- P33681
- Long Name
- CD80 Molecule
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Palmitoylated by ZDHHC20; palmitoylation protects CD80 from ubiquitin-mediated degradation, regulating the protein stability, and ensures its accurate plasma membrane localization.
Glycosylation at Asn53, Asn89, Asn98, Asn186, Asn207, Asn211, Asn226, and Asn232
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 8 sites, 2 N-linked glycans (1 site)
- Protein Refseq
- NP_005182.1
- Function
- Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with the CD28 receptor which is constitutively expressed on the cell surface of T-cells.
Related Resources
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Allograft Rejection
Autoimmune Thyroid Disease
Graft-versus-Host Disease
Maturity Onset Diabetes of the Young
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone AB007"
See other products for "CD80"
Select a product category from the dropdown menu below to view related products.
Please select product type
Chimeric Antibody Products
Immunotoxin Products
Mouse Antibody Products
Fc Glycosylation Antibody Products
Low- or Non-fucosylated Oligosaccharide Antibody Products
Chicken IgY Antibody Products
Neutralizing Antibody Products
Blocking Antibody Products
Rabbit Monoclonal Antibody Products
IgG Antibody Products
ADCC Enhanced Antibody Products
IgM Antibody Products
ScFv Antibody Products
Fab Antibody Products
Antibody Magnetic Beads
Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-215 | Anti-Human CD80 Recombinant Antibody (Galiximab) | WB, ELISA, FC, IP, FuncS, IF, Neut | IgG1 - lambda |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0425-FY9. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
-1.png)
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Application: ELISA, SPR, Inhib, FuncS
-1.png)
Application: IB, ELISA, FC, FuncS
-1.jpg)
-1.png)
Application: WB, ELISA, FC, IHC, IP
Application: ELISA, FuncS, IHC, IF, FC, ADCC
Application: Block, IP, IF, FC
Application: ELISA, WB, FC
Application: ELISA, FC, Inhib, IHC-Fr, WB, IP
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
