Anti-Human ERBB3 Recombinant Antibody (LJM716) (CAT#: TAB-244CL)
Recombinant Human monoclonal antibody expressed in CHO binding to Human ERBB3. LJM716 is an anti-HER3 antibody that inhibits both HER2 and NRG driven tumor growth by trapping HER3 in the inactive conformation.
Specific Inquiry
WB
Figure 1 Identification of LJM716, a HER3-binding monoclonal antibody capable of blocking ligand-dependent and -independent HER3 signaling andcell proliferation.
SKBR-3 cells were treated with 10 mg/mL IgG, MAB3481, and AF234 for one or 24 hours. Cell lysates were harvested andimmunoblotted with antibodies directed against the indicated proteins.
Garner, A. P., Bialucha, C. U., Sprague, E. R., Garrett, J. T., Sheng, Q., Li, S., ... & Chen, Y. (2013). An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin. Cancer research, 73(19), 6024-6035.
ELISA
Figure 2 LJM716 locks HER3 in the inactive conformation and does not block ligand binding.
Binding of LJM716 to HER3 mutants K267A, L268A, and K267A/L268A expressed as recombinant proteins and determined by biochemical ELISA.
Garner, A. P., Bialucha, C. U., Sprague, E. R., Garrett, J. T., Sheng, Q., Li, S., ... & Chen, Y. (2013). An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin. Cancer research, 73(19), 6024-6035.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- WB, ELISA
- Related Disease
- Breast Cancer
Product Property
- Purity
- >95% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE
- Storage
- ≤6 months at 4°C; ≥6 months at -20°C.
Applications
- Application Notes
- This antibody has been reported for use in Western Blot and Enzyme-Linked Immunosorbent Assay.
Target
- Alternative Names
- ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor
- Gene ID
- 2065
- UniProt ID
- P21860
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "ERBB3"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1729-sdAb | Recombinant Anti-human ERBB3 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| TAB-070CT | Llama Anti-ERBB3 Recombinant Single Domain Antibody (TAB-070CT) | FC, Block | Llama VHH |
| PABC-556 | Recombinant Llama Anti-ERBB3 Single Domain Antibody (BCD090-M2) | ELISA, SPR | Llama VHH |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H21 | Anti-Human ERBB3 Recombinant Antibody (Duligotuzumab) | FC, IP, ELISA, Neut, FuncS, IF, WB | Human IgG |
| TAB-062CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-062CT-F(E)) | ELISA, Inhib, FC | Human Fab |
| TAB-065CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-065CT-F(E)) | ELISA, FC | Human Fab |
| TAB-066CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-066CT-F(E)) | ELISA, Inhibion, FC | Human Fab |
| TAB-422CQ | Anti-Human ERBB3 Recombinant Antibody (Elgemtumab) | ELISA, IHC, FC, IP, IF, BL | IgG1, κ |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L074E | HRGβ2-PE immunotoxin | Cytotoxicity assay, Functional assay |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0552CL-F(E) | Mouse Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-0552CL-F(E)) | ELISA, Inhib | Mouse Fab |
| TAB-0553CL-F(E) | Mouse Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-0553CL-F(E)) | ELISA, Inhib | Mouse Fab |
| TAB-060CT | Rabbit Anti-ERBB3 Recombinant Antibody (TAB-060CT) | Inhib, ELISA | Rabbit IgG |
| TAB-064CT-F(E) | Mouse Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-064CT-F(E)) | ELISA, FC | Mouse Fab |
| TAB-067CT-F(E) | Anti-Human HER3 Recombinant Antibody Fab Fragment (5101) | ELISA, Inhibition, FC |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-057CT | Human Anti-ERBB3 Recombinant Antibody (TAB-057CT) | Inhibion, ELISA | Humanized antibody |
| TAB-058CT | Human Anti-ERBB3 Recombinant Antibody (TAB-058CT) | ELISA, Inhib, Cty, IHC, WB, FC | Human IgG1, κ |
| TAB-057CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-057CT-S(P)) | Inhibion, ELISA | Humanized scFv |
| TAB-058CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-058CT-S(P)) | WB, ELISA, Inhib | Human scFv |
| TAB-059CT-S(P) | Anti-Human HER3 Recombinant Antibody scFv Fragment (LMAb3) | WB, ELISA, Inhibition, FC | Humanized antibody |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-061CT | Human Anti-ERBB3 Recombinant Antibody (TAB-061CT) | Inhib, ELISA | Chimeric (Rabbit/Human) antibody |
| TAB-061CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-061CT-S(P)) | Inhib, ELISA | Human scFv |
| TAB-061CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-061CT-F(E)) | Inhib, ELISA | Chimeric (Rabbit/Human) Fab |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-738CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone CBL932) | Neut, IP | Mouse IgG1 |
| NEUT-739CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone CBL483) | FC, CyTOF®, ELISA, Neut | Mouse IgG1 |
| NEUT-740CQ | Human Anti-ERBB3 Recombinant Antibody (clone CBL1019) | Neut | Human IgG1, κ |
| NEUT-741CQ | Human Anti-ERBB3 Recombinant Antibody (clone CBL1020) | Neut | Human IgG1, κ |
| NEUT-742CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone M908) | Neut | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1179 | Hi-Affi™ Rabbit Anti-ERBB3 Recombinant Antibody (clone DS1179AB) | ICC, IF, WB | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0286-YC | Mouse Anti-ERBB3 Recombinant Antibody (clone 1153) | ELISA, FuncS, FC | Mouse IgG |
| HPAB-0287-YC | Mouse Anti-ERBB3 Recombinant Antibody (clone 920104) | ELISA, FuncS, FC | Mouse IgG |
| HPAB-0288-YC | Mouse Anti-ERBB3 Recombinant Antibody (clone 1126) | ELISA, FuncS, FC | Mouse IgG |
| HPAB-0289-YC | Mouse Anti-ERBB3 Recombinant Antibody (clone 12511) | ELISA, FuncS, FC | Mouse IgG |
| HPAB-0290-YC | Human Anti-ERBB3 Recombinant Antibody (HPAB-0290-YC) | ELISA, FuncS, FC | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0286-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 1153); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
| HPAB-0287-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 920104); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
| HPAB-0288-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 1126); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
| HPAB-0289-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 12511); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
| HPAB-0290-YC-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-0290-YC-F(E)) | ELISA, FuncS, FC | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H21 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-422CQ | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Elgemtumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, BL | ADCC enhanced antibody |
| AFC-TAB-189 | Afuco™ Anti-ERBB3 Recombinant Antibody (AFC-TAB-189), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | Human IgG1, κ |
| AFC-TAB-H22 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotuzumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| AFC-TAB-892 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Seribantumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0436-FY-S(P) | Mouse Anti-ERBB3 Recombinant Antibody (clone 15D5); scFv Fragment | Inhib | Mouse scFv |
| HPAB-0437-FY-S(P) | Mouse Anti-ERBB3 Recombinant Antibody (clone 1D9); scFv Fragment | Inhib | Humanized scFv |
| HPAB-0438-FY-S(P) | Mouse Anti-ERBB3 Recombinant Antibody (clone 993); scFv Fragment | FC, Inhib | Mouse scFv |
| FAMAB-0047JF-S(P) | Human Anti-ERBB3 Recombinant Antibody (clone PM6); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| PSBS-0069 | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (PSBS-0069) | ELISA, Block, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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