Anti-Human ERBB3 Recombinant Antibody (LJM716) (CAT#: TAB-244CL)
Recombinant Human monoclonal antibody expressed in CHO binding to Human ERBB3. LJM716 is an anti-HER3 antibody that inhibits both HER2 and NRG driven tumor growth by trapping HER3 in the inactive conformation.
Specific Inquiry
WB
Figure 1 Identification of LJM716, a HER3-binding monoclonal antibody capable of blocking ligand-dependent and -independent HER3 signaling andcell proliferation.
SKBR-3 cells were treated with 10 mg/mL IgG, MAB3481, and AF234 for one or 24 hours. Cell lysates were harvested andimmunoblotted with antibodies directed against the indicated proteins.
Garner, A. P., Bialucha, C. U., Sprague, E. R., Garrett, J. T., Sheng, Q., Li, S., ... & Chen, Y. (2013). An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin. Cancer research, 73(19), 6024-6035.
ELISA
Figure 2 LJM716 locks HER3 in the inactive conformation and does not block ligand binding.
Binding of LJM716 to HER3 mutants K267A, L268A, and K267A/L268A expressed as recombinant proteins and determined by biochemical ELISA.
Garner, A. P., Bialucha, C. U., Sprague, E. R., Garrett, J. T., Sheng, Q., Li, S., ... & Chen, Y. (2013). An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin. Cancer research, 73(19), 6024-6035.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- WB, ELISA
- Related Disease
- Breast Cancer
Product Property
- Purity
- >95% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE
- Storage
- ≤6 months at 4°C; ≥6 months at -20°C.
Applications
- Application Notes
- This antibody has been reported for use in Western Blot and Enzyme-Linked Immunosorbent Assay.
Target
- Alternative Names
- ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor
- Gene ID
- 2065
- UniProt ID
- P21860
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Single-domain Antibody
Human Antibody
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Immunotoxin
Fab Fragment Antibody
Mouse Antibody
Chimeric Antibody
Recombinant Antibody
Neutralizing Antibody
Rabbit Monoclonal Antibody
ADCC Enhanced Antibody
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1729-sdAb | Recombinant Anti-human ERBB3 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| TAB-070CT | Llama Anti-ERBB3 Recombinant Single Domain Antibody (TAB-070CT) | FC, Block | Llama VHH |
| PABC-556 | Recombinant Llama Anti-ERBB3 Single Domain Antibody (PABC-556) | ELISA, SPR | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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