Anti-EpCAM Immunocytokine, GM-CSF-FAB (L19) (ACFP-SH049)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM FAB to GM-CSF. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EpCAM as well as the biological activity of GM-CSF. This fusion protein was directed against EpCAM and induced tumor cell lysis in vitro, which was dependent on the presence of the cytokine. Thus, GM-CSF activated PBMCs to lyse tumor cells, while IL-2 redirected lysis by T cells. This immunocytokine was designed for treating solid tumor.
Specifications
- Target
- EpCAM
- Molecule Class
- GM-CSF-FAB
- Species Reactivity
- Human
- Host
- Human
- Expression Host
- CHO
- Clone
- L19
- Related Disease
- Solid tumors
- Cytokines 1
- GM-CSF
- Cytokines 1 Description
- Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2
- Entrez Gene ID
- 4072
- UniProt ID
- P16422
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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