Anti-EpCAM Antibody-Cytokine Fusion Protein, scFv-CH1 (HD70)-GM-CSF: scFv-Cκ (HD70)-IL2 (CAT#: ACFP-SH194)

• Target
• EpCAM

• Molecule Class
• scFv-CH1-GM-CSF; scFv-Cκ-IL2

• Species Reactivity
• Human

• Expression Host
• CHO

• Clone
• HD70

• Related Disease
• EpCAM over-expressing cancers

• Cytokine 1
• IL2

• Cytokines 1 Description
• Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.

• Cytokine 1 Species
• Human

• Cytokine 2
• GM-CSF

• Cytokines 2 Description
• Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim.

• Cytokine 2 Species
• Human

• Applications
• This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

• Alternative Names
• EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component; chromosome 4; surface marker (35kD glycoprotein)

• Gene ID
• 4072

• UniProt ID
• P16422

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