Anti-PrP antibody is a Mouse of scFv class that binds to an PrP.
Figure 1 Epitope specificity of the neurotoxicity mediated by antiprion antibodies.
Antibody binding sites on PrP(23–230). POM6–9, 13, 15 and 17 bind helix a1 and compete with POM1 (ref. 3). POM6 and POM7 (light orange) show additional binding sites at helix a2 (drk orange), whereas POM5 recognizes a unique epitope at the b2–a2 transition (green, Supplementary Table 2). The GD image was rendered using the PDB structure 2L1H.
Sonati, T., Reimann, R. R., Falsig, J., Baral, P. K., O’connor, T., Hornemann, S., ... & Swayampakula, M. (2013). The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature, 501(7465), 102.
Figure 2 In vivo toxicity of antibodies binding to PrP.
Manganeseenhanced magnetic resonance imaging (MEMRI) scans showed hypointense lesions in POM1-treated (6 mg in 2ml) wild-type (WT) and tga20 mice (left panels) 72 h post intracerebellar injection.
Sonati, T., Reimann, R. R., Falsig, J., Baral, P. K., O’connor, T., Hornemann, S., ... & Swayampakula, M. (2013). The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature, 501(7465), 102.
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CAT | Product Name | Application | Type |
---|---|---|---|
IAB-B034(A) | Recombinant Anti-human PRNP Intrabody [(D-Arg)9] | IF, FC, WB, FuncS | scFv-(D-Arg)9 |
IAB-B034(G) | Recombinant Anti-human PRNP Intrabody [+36 GFP] | WB, CO-IP, FuncS | scFv-(+36GFP) |
IAB-B034(T) | Recombinant Anti-human PRNP Intrabody [Tat] | IF, ELISA, FuncS | scFv-Tat |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-310 | Mouse Anti-PRNP Recombinant Antibody (clone POM2) | WB, IHC, FuncS | Mouse IgG |
MOB-1629CT | Recombinant Mouse anti-Human PRNP Monoclonal antibody (6C0) | ELISA, WB | |
FAMAB-0056-CN | Human Anti-PRNP Recombinant Antibody (clone hu4.17) | ELISA | Human IgG |
FAMAB-0057-CN | Human Anti-PRNP Recombinant Antibody (clone hu4.06) | ELISA | Human IgG |
FAMAB-0058-CN | Human Anti-PRNP Recombinant Antibody (clone hu4.32) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-310 | Mouse Anti-PRNP Recombinant Antibody (clone POM2); scFv Fragment | WB, IHC, FuncS | Mouse scFv |
FAMAB-0272CQ-S(P) | Mouse Anti-PRNP Recombinant Antibody (clone ch31C6); scFv Fragment | ELISA, WB, IHC | Mouse scFv |
HPAB-1462LY-S(P) | Mouse Anti-PRNP Recombinant Antibody (clone CBL030); scfv Fragment | ELISA, WB, Inhib | Mouse scfv |
HPAB-0909-FY-F(E) | Mouse Anti-PRNP Recombinant Antibody (clone APR3); scFv Fragment | WB, ELISA | Mouse scFv |
PABX-161-S(P) | Mouse Anti-PRNP Recombinant Antibody (clone POM1); scFv Fragment | ELISA, IP, IHC, FuncS | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PNBL-026 | Recombinant Anti-Human PRNP VHH Single Domain Antibody (Nb484) | WB, ELISA, FuncS | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBW-089 | Mouse Anti-PRNP Recombinant Antibody (clone 3F4); Fab Fragment | ELISA | Mouse Fab |
HPAB-0282CQ-F(E) | Human Anti-PRNP Recombinant Antibody (clone boPrP-15); Fab Fragment | ELISA, WB | Human Fab |
HPAB-0283CQ-F(E) | Human Anti-PRNP Recombinant Antibody (clone huPrP-18); Fab Fragment | ELISA, WB | Human Fab |
HPAB-0284CQ-F(E) | Human Anti-PRNP Recombinant Antibody (clone huPrP-39); Fab Fragment | ELISA, WB | Human Fab |
HPAB-0285CQ-F(E) | Human Anti-PRNP Recombinant Antibody (clone boPrP-20); Fab Fragment | ELISA, WB | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-943LC | Anti-Mouse Prnp Recombinant Antibody (D13) | ELISA | Human antibody |
MRO-944LC | Anti-Mouse Prnp Recombinant Antibody (D18) | ELISA | Human antibody |
MRO-945LC | Anti-Mouse Prnp Recombinant Antibody (R72) | ELISA | Human antibody |
MRO-946LC | Anti-Mouse Prnp Recombinant Antibody (R1) | ELISA | Human antibody |
MRO-947LC | Anti-Mouse Prnp Recombinant Antibody (R2) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-942LC-S(P) | Anti-Sheep PRNP Recombinant Antibody scFv Fragment (6.1) | ELISA | Mouse antibody |
MRO-948LC-S(P) | Anti-Mouse Prnp Recombinant Antibody scFv Fragment (6H10) | ELISA | Mouse antibody |
MRO-949LC-S(P) | Anti-Mouse Prnp Recombinant Antibody scFv Fragment (31C6) | ELISA | Mouse antibody |
MRO-950LC-S(P) | Anti-Mouse Prnp Recombinant Antibody scFv Fragment (72-5) | ELISA | Mouse antibody |
MRO-951LC-S(P) | Anti-Mouse Prnp Recombinant Antibody scFv Fragment (44B1) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0727MZ | Chicken Anti-PRNP Polyclonal IgY | ICC/IF | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2871 | Hi-Affi™ Recombinant Rabbit Anti-PRNP Monoclonal Antibody (DS2871AB) | WB, FC, IHC-P, ICC/IF | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-0079LC | Recombinant Mouse Anti-Sheep Prnp Antibody (12B2) | WB | IgG |
EPAF-0087LC | Recombinant Mouse Anti-Sheep Prnp Antibody (ICSM18) | WB | IgG |
EPAF-0277CQ | Mouse Anti-PRNP Recombinant Antibody (clone 4H8) | Inhib | Mouse IgG2b |
EPAF-0278CQ | Mouse Anti-PRNP Recombinant Antibody (clone 6BH) | Inhib | Mouse IgG1 |
EPAF-0279CQ | Mouse Anti-PRNP Recombinant Antibody (clone 3F10) | WB | Mouse IgG1 |
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