Recombinant Mouse Anti-PrP Antibody Fab Fragment (POM1) (CAT#: PABX-161-F (E))
Anti-PrP antibody is a Mouse of Fab class that binds to an PrP.
Specific Inquiry
-1.png)
Figure 1 Epitope specificity of the neurotoxicity mediated by antiprion antibodies.
Antibody binding sites on PrP(23–230). POM6–9, 13, 15 and 17 bind helix a1 and compete with POM1 (ref. 3). POM6 and POM7 (light orange) show additional binding sites at helix a2 (drk orange), whereas POM5 recognizes a unique epitope at the b2–a2 transition (green, Supplementary Table 2). The GD image was rendered using the PDB structure 2L1H.
Sonati, T., Reimann, R. R., Falsig, J., Baral, P. K., O’connor, T., Hornemann, S., ... & Swayampakula, M. (2013). The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature, 501(7465), 102.
-2.png)
Figure 2 In vivo toxicity of antibodies binding to PrP.
Manganeseenhanced magnetic resonance imaging (MEMRI) scans showed hypointense lesions in POM1-treated (6 mg in 2ml) wild-type (WT) and tga20 mice (left panels) 72 h post intracerebellar injection.
Sonati, T., Reimann, R. R., Falsig, J., Baral, P. K., O’connor, T., Hornemann, S., ... & Swayampakula, M. (2013). The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature, 501(7465), 102.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- Fab
- Specificity
- Tested positive against native Human PrP
- Species Reactivity
- Human
- Clone
- POM1
- Applications
- WB 1:1000-1:5000
ELISA 1:10000-1:20000
FuncS (assay dependent)
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
- Alternative Names
- PRNP; prion protein; PrP; PrPC; Sinc; CD230; PrPSc; Prn-i; Prn-p; PrP<C>; AA960666; AI325101; prP27-30; prP33-35C; major prion protein;
- Gene ID
- 19122
- UniProt ID
- P04925
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B034(A) | Recombinant Anti-human PRNP Intrabody [(D-Arg)9] | IF, FC, WB, FuncS | scFv-(D-Arg)9 |
| IAB-B034(G) | Recombinant Anti-human PRNP Intrabody [+36 GFP] | WB, CO-IP, FuncS | scFv-(+36GFP) |
| IAB-B034(T) | Recombinant Anti-human PRNP Intrabody [Tat] | IF, ELISA, FuncS | scFv-Tat |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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